The Future of Aging Research

por Helfand, Stephen, Taylor, Jackson
Publicado 2020

Indy Mutations and Drosophila Longevity

por Rogina, Blanka, Helfand, Stephen L.
Publicado 2013

New tricks of an old molecule: lifespan regulation by p53

por Bauer, Johannes H, Helfand, Stephen L
Publicado 2006

Indy knockdown in mice mimics elements of dietary restriction

por Shulman, Gerald I., Helfand, Stephen L.
Publicado 2011

Chromatin structure and transposable elements in organismal aging

por Wood, Jason G., Helfand, Stephen L.
Publicado 2013

The longevity transporter mIndy (Slc13a5) as a target for treating hepatic steatosis and insulin resistance

por Willmes, Diana M., Helfand, Stephen L., Birkenfeld, Andreas L.
Publicado 2016

Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion

por Zhu, Chen-Tseh, Chang, Chengyi, Reenan, Robert A., Helfand, Stephen L.
Publicado 2014

New comparative genomics approach reveals a conserved health span signature across species

por Antosh, Michael, Fox, David, Helfand, Stephen L., Cooper, Leon N, Neretti, Nicola
Publicado 2011

Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster

por Whitaker, Rachel, Gil, M. Pilar, Ding, Feifei, Tatar, Marc, Helfand, Stephen L., Neretti, Nicola
Publicado 2014

Comparative transcriptional profiling identifies takeout as a gene that regulates life span

por Bauer, Johannes, Antosh, Michael, Chang, Chengyi, Schorl, Christoph, Kolli, Santharam, Neretti, Nicola, Helfand, Stephen L.
Publicado 2010

Increased expression of Drosophila Sir 2 extends life span in a dose-dependent manner

por Whitaker, Rachel, Faulkner, Shakeela, Miyokawa, Reika, Burhenn, Lucas, Henriksen, Mark, Wood, Jason G., Helfand, Stephen L.
Publicado 2013

Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging

por Jiang, Nan, Du, Guyu, Tobias, Ethan, Wood, Jason G., Whitaker, Rachel, Neretti, Nicola, Helfand, Stephen L.
Publicado 2013

Mechanisms of Lifespan Extension by Sirt6 in Drosophila melanogaster

por Taylor, Jackson, Wood, Jason, Finn, Matthew, Liu, Julianna, Mizerak, Evan, Gordon, Sarah, Hutfilz, Corinne, Helfand, Stephen
Publicado 2020

dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster

por Bauer, Johannes H., Morris, Siti Nur Sarah, Chang, Chengyi, Flatt*, Thomas, Wood, Jason G., Helfand, Stephen L.
Publicado 2008

Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span

por Pu, Mintie, Ni, Zhuoyu, Wang, Minghui, Wang, Xiujuan, Wood, Jason G., Helfand, Stephen L., Yu, Haiyuan, Lee, Siu Sylvia
Publicado 2015

Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan

por Fridell, Yih-Woei C., Hoh, Melissa, Kréneisz, Orsolya, Hosier, Suzanne, Chang, Chengyi, Scantling, Dane, Mulkey, Daniel K., Helfand, Stephen L.
Publicado 2009

A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan

por Jones, Brian C., Wood, Jason G., Chang, Chengyi, Tam, Austin D., Franklin, Michael J., Siegel, Emily R., Helfand, Stephen L.
Publicado 2016

Sirt6 regulates lifespan in Drosophila melanogaster

por Taylor, Jackson R., Wood, Jason G., Mizerak, Evan, Hinthorn, Samuel, Liu, Julianna, Finn, Matthew, Gordon, Sarah, Zingas, Louis, Chang, Chengyi, Klein, Mark A., Denu, John M., Gorbunova, Vera, Seluanov, Andrei, Boeke, Jef D., Sedivy, John M., Helfand, Stephen L.
Publicado 2022

A specialized metabolic pathway partitions citrate in hydroxyapatite to impact mineralization of bones and teeth

por Dirckx, Naomi, Zhang, Qian, Chu, Emily Y., Tower, Robert J., Li, Zhu, Guo, Shenghao, Yuan, Shichen, Khare, Pratik A., Zhang, Cissy, Verardo, Angela, Alejandro, Lucy O., Park, Angelina, Faugere, Marie-Claude, Helfand, Stephen L., Somerman, Martha J., Riddle, Ryan C., de Cabo, Rafael, Le, Anne, Schmidt-Rohr, Klaus, Clemens, Thomas L.
Publicado 2022

LINE-1 derepression in senescent cells triggers interferon and inflammaging

por Cecco, Marco De, Ito, Takahiro, Petrashen, Anna P., Elias, Amy E., Skvir, Nicholas J., Criscione, Steven W., Caligiana, Alberto, Brocculi, Greta, Adney, Emily M., Boeke, Jef D., Le, Oanh, Beauséjour, Christian, Ambati, Jayakrishna, Ambati, Kameshwari, Simon, Matthew, Seluanov, Andrei, Gorbunova, Vera, Slagboom, P. Eline, Helfand, Stephen L., Neretti, Nicola, Sedivy, John M.
Publicado 2019