The Ins and Outs of Autophagy and Metabolism in Hematopoietic and Leukemic Stem Cells: Food for Thought

por Ianniciello, Angela, Rattigan, Kevin M., Helgason, G. Vignir
Publicado 2018

Mitochondrial metabolism as a potential therapeutic target in myeloid leukaemia

por de Beauchamp, Lucie, Himonas, Ekaterini, Helgason, G. Vignir
Publicado 2021

Unraveling Heterogeneity in the Aging Hematopoietic Stem Cell Compartment: An Insight From Single-cell Approaches

por Yang, Fei, Nourse, Craig, Helgason, G. Vignir, Kirschner, Kristina
Publicado 2023

Metabolism in stem cell–driven leukemia: parallels between hematopoiesis and immunity

por Rattigan, Kevin M., Zarou, Martha M., Helgason, G. Vignir
Publicado 2023

Utilizing Stimulated Raman Scattering Microscopy To Study Intracellular Distribution of Label-Free Ponatinib in Live Cells

por Sepp, Kristel, Lee, Martin, Bluntzer, Marie T. J., Helgason, G. Vignir, Hulme, Alison N., Brunton, Valerie G.
Publicado 2019

BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia

por Parry, Narissa, Busch, Caroline, Aßmann, Victoria, Cassels, Jennifer, Hair, Alan, Helgason, G. Vignir, Wheadon, Helen, Copland, Mhairi
Publicado 2022

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemic stem cells

por Kuntz, Elodie M., Baquero, Pablo, Michie, Alison M., Dunn, Karen, Tardito, Saverio, Holyoake, Tessa L., Helgason, G. Vignir, Gottlieb, Eyal
Publicado 2017

ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells

por Karvela, Maria, Baquero, Pablo, Kuntz, Elodie M., Mukhopadhyay, Arunima, Mitchell, Rebecca, Allan, Elaine K., Chan, Edmond, Kranc, Kamil R., Calabretta, Bruno, Salomoni, Paolo, Gottlieb, Eyal, Holyoake, Tessa L., Helgason, G. Vignir
Publicado 2016

The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors

por Pellicano, Francesca, Scott, Mary T, Helgason, G Vignir, Hopcroft, Lisa E M, Allan, Elaine K, Aspinall-O'Dea, Mark, Copland, Mhairi, Pierce, Andrew, Huntly, Brian J P, Whetton, Anthony D, Holyoake, Tessa L
Publicado 2014

Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells

por Rattigan, Kevin M, Zarou, Martha M, Brabcova, Zuzana, Prasad, Bodhayan, Zerbst, Désirée, Sarnello, Daniele, Kalkman, Eric R, Ianniciello, Angela, Scott, Mary T, Dunn, Karen, Shokry, Engy, Sumpton, David, Copland, Mhairi, Tardito, Saverio, Vande Voorde, Johan, Mussai, Francis, Cheng, Paul, Helgason, G Vignir
Publicado 2023

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

por Baquero, Pablo, Dawson, Amy, Mukhopadhyay, Arunima, Kuntz, Elodie M., Mitchell, Rebecca, Olivares, Orianne, Ianniciello, Angela, Scott, Mary T., Dunn, Karen, Nicastri, Michael C., Winkler, Jeffrey D., Michie, Alison M., Ryan, Kevin M., Halsey, Christina, Gottlieb, Eyal, Keaney, Erin P., Murphy, Leon O., Amaravadi, Ravi K., Holyoake, Tessa L., Helgason, G. Vignir
Publicado 2018

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death

por Woodley, Keith, Dillingh, Laura S., Giotopoulos, George, Madrigal, Pedro, Rattigan, Kevin M., Philippe, Céline, Dembitz, Vilma, Magee, Aoife M. S., Asby, Ryan, van de Lagemaat, Louie N., Mapperley, Christopher, James, Sophie C., Prehn, Jochen H. M., Tzelepis, Konstantinos, Rouault-Pierre, Kevin, Vassiliou, George S., Kranc, Kamil R., Helgason, G. Vignir, Huntly, Brian J. P., Gallipoli, Paolo
Publicado 2023

Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition

por Mitchell, Rebecca, Hopcroft, Lisa E M, Baquero, Pablo, Allan, Elaine K, Hewit, Kay, James, Daniel, Hamilton, Graham, Mukhopadhyay, Arunima, O’Prey, Jim, Hair, Alan, Melo, Junia V, Chan, Edmond, Ryan, Kevin M, Maguer-Satta, Véronique, Druker, Brian J, Clark, Richard E, Mitra, Subir, Herzyk, Pawel, Nicolini, Franck E, Salomoni, Paolo, Shanks, Emma, Calabretta, Bruno, Holyoake, Tessa L, Helgason, G Vignir
Publicado 2017

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

por Smith, Lindsay D., Minton, Annabel R., Blunt, Matthew D., Karydis, Laura I., Dutton, David A., Rogers-Broadway, Karly-Rai, Dobson, Rachel, Liu, Rena, Norster, Faith, Hogg, Elizabeth, Ashton-Key, Margaret, Strefford, Jonathan C., Jia, Li, Efremov, Dimitar G., Helgason, G. Vignir, Johnson, Peter W. M., Stevenson, Freda K., Forconi, Francesco, Cragg, Mark S., Tumbarello, David A., Packham, Graham, Steele, Andrew J.
Publicado 2019