Quantitative Comparison of the Efficacy of Various Compounds in Lowering Intracellular Cholesterol Levels in Niemann-Pick Type C Fibroblasts

por Wehrmann, Zachary T., Hulett, Tyler W., Huegel, Kara L., Vaughan, Kevin T., Wiest, Olaf, Helquist, Paul, Goodson, Holly
Publicado 2012

Proofreading experimentally assigned stereochemistry through Q2MM predictions in Pd-catalyzed allylic aminations

por Wahlers, Jessica, Margalef, Jèssica, Hansen, Eric, Bayesteh, Armita, Helquist, Paul, Diéguez, Montserrat, Pàmies, Oscar, Wiest, Olaf, Norrby, Per-Ola
Publicado 2021

Automated fitting of transition state force fields for biomolecular simulations

por Quinn, Taylor R., Patel, Himani N., Koh, Kevin H., Haines, Brandon E., Norrby, Per-Ola, Helquist, Paul, Wiest, Olaf
Publicado 2022

Biocompatible, Multi-Mode, Fluorescent, T(2) MRI Contrast Magnetoelectric-Silica Nanoparticles (MagSiNs), for On-Demand Doxorubicin Delivery to Metastatic Cancer Cells

por Waters, Margo, Hopf, Juliane, Tam, Emma, Wallace, Stephanie, Chang, Jordan, Bennett, Zach, Aquino, Hadrian, Roeder, Ryan K., Helquist, Paul, Stack, M. Sharon, Nallathamby, Prakash D.
Publicado 2022

Microsecond timescale MD simulations at the transition state of PmHMGR predict remote allosteric residues

por Quinn, Taylor R., Steussy, Calvin N., Haines, Brandon E., Lei, Jinping, Wang, Wei, Sheong, Fu Kit, Stauffacher, Cynthia V., Huang, Xuhui, Norrby, Per-Ola, Helquist, Paul, Wiest, Olaf
Publicado 2021

HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts

por Pipalia, Nina H., Saad, Syed Z., Subramanian, Kanagaraj, Cross, Abigail, al-Motawa, Aisha, Garg, Kunal, Blagg, Brian S.J., Neckers, Len, Helquist, Paul, Wiest, Olaf, Ory, Daniel S., Maxfield, Frederick R.
Publicado 2021

Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts

por Cruz, Dana L., Pipalia, Nina, Mao, Shu, Gadi, Deepti, Liu, Gang, Grigalunas, Michael, O’Neill, Matthew, Quinn, Taylor R., Kipper, Andi, Ekebergh, Andreas, Dimmling, Alexander, Gartner, Carlos, Melancon, Bruce J., Wagner, Florence F., Holson, Edward, Helquist, Paul, Wiest, Olaf, Maxfield, Frederick R.
Publicado 2021