Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity

por Leonard, Elissa K., Tomala, Jakub, Gould, Joseph R., Leff, Michael I., Lin, Jian-Xin, Li, Peng, Porter, Mitchell J., Johansen, Eric R., Thompson, Ladaisha, Cao, Shanelle D., Henclova, Tereza, Huliciak, Maros, Vaněk, Ondřej, Kovar, Marek, Leonard, Warren J., Spangler, Jamie B.
Publicado 2023

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

por VanDyke, Derek, Iglesias, Marcos, Tomala, Jakub, Young, Arabella, Smith, Jennifer, Perry, Joseph A., Gebara, Edward, Cross, Amy R., Cheung, Laurene S., Dykema, Arbor G., Orcutt-Jahns, Brian T., Henclová, Tereza, Golias, Jaroslav, Balolong, Jared, Tomasovic, Luke M., Funda, David, Meyer, Aaron S., Pardoll, Drew M., Hester, Joanna, Issa, Fadi, Hunter, Christopher A., Anderson, Mark S., Bluestone, Jeffrey A., Raimondi, Giorgio, Spangler, Jamie B.
Publicado 2022