LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons

por Henderson, Michael X., Peng, Chao, Trojanowski, John Q., Lee, Virginia M. Y.
Publicado 2018

Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease

por Henderson, Michael X., Sengupta, Medha, Trojanowski, John Q., Lee, Virginia M. Y.
Publicado 2019

LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons

por Henderson, Michael X., Changolkar, Lakshmi, Trojanowski, John Q., Lee, Virginia M.Y.
Publicado 2021

The roles of connectivity and neuronal phenotype in determining the pattern of α-synuclein pathology in Parkinson's disease

por Henderson, Michael X., Henrich, Martin T., Geibl, Fanni F., Oertel, Wolfgang H., Brundin, Patrik, Surmeier, D. James
Publicado 2022

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

por Henderson, Michael X., Sengupta, Medha, McGeary, Ian, Zhang, Bin, Olufemi, Modupe F., Brown, Hannah, Trojanowski, John Q., Lee, Virginia M. Y.
Publicado 2019

Spatial transcriptomics reveals molecular dysfunction associated with Lewy pathology

por Goralski, Thomas, Meyerdirk, Lindsay, Breton, Libby, Brasseur, Laura, Kurgat, Kevin, DeWeerd, Daniella, Turner, Lisa, Becker, Katelyn, Adams, Marie, Newhouse, Daniel, Henderson, Michael X.
Publicado 2023

α-Synuclein pathology spread through the brain connectome is modulated by selective vulnerability and predicted by network analysis

por Henderson, Michael X., Cornblath, Eli J., Darwich, Adam, Zhang, Bin, Brown, Hannah, Gathagan, Ronald J., Sandler, Raizel M., Bassett, Danielle S., Trojanowski, John Q., Lee, Virginia M.Y.
Publicado 2019

Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor

por Cornblath, Eli J., Li, Howard L., Changolkar, Lakshmi, Zhang, Bin, Brown, Hannah J., Gathagan, Ronald J., Olufemi, Modupe F., Trojanowski, John Q., Bassett, Danielle S., Lee, Virginia M. Y., Henderson, Michael X.
Publicado 2021

Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala

por Chen, Liqiang, Nagaraja, Chetan, Daniels, Samuel, Fisk, Zoe A, Dvorak, Rachel, Meyerdirk, Lindsay, Steiner, Jennifer A, Escobar Galvis, Martha L, Henderson, Michael X, Rousseaux, Maxime WC, Brundin, Patrik, Chu, Hong-Yuan
Publicado 2022

A novel automated morphological analysis of Iba1+ microglia using a deep learning assisted model

por Stetzik, Lucas, Mercado, Gabriela, Smith, Lindsey, George, Sonia, Quansah, Emmanuel, Luda, Katarzyna, Schulz, Emily, Meyerdirk, Lindsay, Lindquist, Allison, Bergsma, Alexis, Jones, Russell G., Brundin, Lena, Henderson, Michael X., Pospisilik, John Andrew, Brundin, Patrik
Publicado 2022

Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson’s disease

por Leyns, Cheryl E. G., Prigent, Alice, Beezhold, Brenna, Yao, Lihang, Hatcher, Nathan G., Tao, Peining, Kang, John, Suh, EunRan, Van Deerlin, Vivianna M., Trojanowski, John Q., Lee, Virginia M. Y., Kennedy, Matthew E., Fell, Matthew J., Henderson, Michael X.
Publicado 2023

A rapid microglial metabolic response controls metabolism and improves memory

por Drougard, Anne, Ma, Eric H, Wegert, Vanessa, Sheldon, Ryan, Panzeri, Ilaria, Vatsa, Naman, Apostle, Stefanos, Fagnocchi, Luca, Schaf, Judith, Gossens, Klaus, Völker, Josephine, Pang, Shengru, Bremser, Anna, Dror, Erez, Giacona, Francesca, Sagar, Henderson, Michael X, Prinz, Marco, Jones, Russell G, Pospisilik, J. Andrew
Publicado 2023

Urinary tract infections trigger synucleinopathy via the innate immune response

por Peelaerts, Wouter, Mercado, Gabriela, George, Sonia, Villumsen, Marie, Kasen, Alysa, Aguileta, Miguel, Linstow, Christian, Sutter, Alexandra B., Kuhn, Emily, Stetzik, Lucas, Sheridan, Rachel, Bergkvist, Liza, Meyerdirk, Lindsay, Lindqvist, Allison, Gavis, Martha L. Escobar, Van den Haute, Chris, Hultgren, Scott J., Baekelandt, Veerle, Pospisilik, J. Andrew, Brudek, Tomasz, Aznar, Susana, Steiner, Jennifer A., Henderson, Michael X., Brundin, Lena, Ivanova, Magdalena I., Hannan, Tom J., Brundin, Patrik
Publicado 2023