Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα “don’t eat me” immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-prese...

por Hendriks, Mark A. J. M., Ploeg, Emily M., Koopmans, Iris, Britsch, Isabel, Ke, Xiurong, Samplonius, Douwe F., Helfrich, Wijnand
Publicado 2020

Novel Fab-peptide-HLA-I fusion proteins for redirecting pre-existing anti-CMV T cell immunity to selective eliminate carcinoma cells

por Britsch, Isabel, van Wijngaarden, Anne P., Ke, Xiurong, Hendriks, Mark. A.J.M., Samplonius, Douwe F., Ploeg, Emily M., Helfrich, Wijnand
Publicado 2023

Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis

por Hendriks, Mark A.J.M., Britsch, Isabel, Ke, Xiurong, van Wijngarden, Anne P., Samplonius, Douwe F., Ploeg, Emily M., Helfrich, Wijnand
Publicado 2021

CD20-selective inhibition of CD47-SIRPα “don't eat me” signaling with a bispecific antibody-derivative enhances the anticancer activity of daratumumab, alemtuzumab and obinutuzumab...

por van Bommel, Peter E., He, Yuan, Schepel, Ilona, Hendriks, Mark A. J. M., Wiersma, Valerie R., van Ginkel, Robert J., van Meerten, Tom, Ammatuna, Emanuele, Huls, Gerwin, Samplonius, Douwe F., Helfrich, Wijnand, Bremer, Edwin
Publicado 2017