Structural insights into redox-active cysteine residues of the Src family kinases

por Heppner, David E.
Publicado 2021

Redox-dependent regulation of epidermal growth factor receptor signaling

por Heppner, David E., van der Vliet, Albert
Publicado 2015

Mechanism of the Reduction of the Native Intermediate in the Multicopper Oxidases: Insights into Rapid Intramolecular Electron Transfer in Turnover

por Heppner, David E., Kjaergaard, Christian H., Solomon, Edward I.
Publicado 2014

Architecture of the NADPH oxidase family of enzymes

por Ogboo, Blessing C., Grabovyy, Uriy V., Maini, Aniket, Scouten, Scott, van der Vliet, Albert, Mattevi, Andrea, Heppner, David E.
Publicado 2022

Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?()

por Heppner, David E., Hristova, Milena, Ida, Tomoaki, Mijuskovic, Ana, Dustin, Christopher M., Bogdándi, Virág, Fukuto, Jon M., Dick, Tobias P., Nagy, Péter, Li, Jianing, Akaike, Takaaki, van der Vliet, Albert
Publicado 2017

Direct cysteine sulfenylation drives activation of the Src kinase

por Heppner, David E., Dustin, Christopher M., Liao, Chenyi, Hristova, Milena, Veith, Carmen, Little, Andrew C., Ahlers, Bethany A., White, Sheryl L., Deng, Bin, Lam, Ying-Wai, Li, Jianing, van der Vliet, Albert
Publicado 2018

Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors

por Beyett, Tyler S., To, Ciric, Heppner, David E., Rana, Jaimin K., Schmoker, Anna M., Jang, Jaebong, De Clercq, Dries J. H., Gomez, Gabriel, Scott, David A., Gray, Nathanael S., Jänne, Pasi A., Eck, Michael J.
Publicado 2022

Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics

por Chamberlain, Nicolas, Korwin-Mihavics, Bethany R., Nakada, Emily M., Bruno, Sierra R., Heppner, David E., Chapman, David G., Hoffman, Sidra M., van der Vliet, Albert, Suratt, Benjamin T., Dienz, Oliver, Alcorn, John F., Anathy, Vikas
Publicado 2019

Dysregulated Redox Regulation Contributes to Nuclear EGFR Localization and Pathogenicity in Lung Cancer

por Little, Andrew C., Hristova, Milena, van Lith, Loes, Schiffers, Caspar, Dustin, Christopher M., Habibovic, Aida, Danyal, Karamatullah, Heppner, David E., Lin, Miao-Chong J., van der Velden, Jos, Janssen-Heininger, Yvonne M., van der Vliet, Albert
Publicado 2019

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

por Heppner, David, Wittlinger, Florian, Ogboo, Blessing, Shevchenko, Ekaterina, Damghani, Tahereh, Pham, Calvin, Schaeffner, Ilse, Oligny, Brandon, Chitnis, Surbhi, Beyett, Tyler, Rasch, Alexander, Buckley, Brian, Urul, Daniel, Shaurova, Tatiana, May, Earl, Schaefer, Erik, Eck, Michael, Hershberger, Pamela, Poso, Antti, Laufer, Stefan
Publicado 2023

Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors

por Kobayashi, Yoshihisa, Oxnard, Geoffrey R., Cohen, Elizabeth F., Mahadevan, Navin R., Alessi, Joao V., Hung, Yin P., Bertram, Arrien A., Heppner, David E., Ribeiro, Mauricio F., Sacardo, Karina P., Saddi, Rodrigo, Macedo, Mariana P., Blasco, Rafael B., Li, Jiaqi, Kurppa, Kari J., Nguyen, Tom, Voligny, Emma, Ananda, Guruprasad, Chiarle, Roberto, Katz, Artur, Tolstorukov, Michael Y., Sholl, Lynette M., Jänne, Pasi A.
Publicado 2022