ICOS is required for the generation of both central and effector CD4(+) memory T‐cell populations following acute bacterial infection

por Marriott, Clare L., Carlesso, Gianluca, Herbst, Ronald, Withers, David R.
Publicado 2015

B-cell targeted therapeutics in clinical development

por Blüml, Stephan, McKeever, Kathleen, Ettinger, Rachel, Smolen, Josef, Herbst, Ronald
Publicado 2013

Inebilizumab, a B Cell-Depleting Anti-CD19 Antibody for the Treatment of Autoimmune Neurological Diseases: Insights from Preclinical Studies

por Chen, Ding, Gallagher, Sandra, Monson, Nancy L., Herbst, Ronald, Wang, Yue
Publicado 2016

Characterisation of innate lymphoid cell populations at different sites in mice with defective T cell immunity

por Dutton, Emma E., Camelo, Ana, Sleeman, Matthew, Herbst, Ronald, Carlesso, Gianluca, Belz, Gabrielle T., Withers, David R.
Publicado 2018

Germinal Center B Cell Depletion Diminishes CD4(+) Follicular T Helper Cells in Autoimmune Mice

por Yusuf, Isharat, Stern, Jessica, McCaughtry, Tom M., Gallagher, Sandra, Sun, Hong, Gao, Changshou, Tedder, Thomas, Carlesso, Gianluca, Carter, Laura, Herbst, Ronald, Wang, Yue
Publicado 2014

RAGE inhibits human respiratory syncytial virus syncytium formation by interfering with F-protein function

por Tian, Jane, Huang, Kelly, Krishnan, Subramaniam, Svabek, Catherine, Rowe, Daniel C., Brewah, Yambasu, Sanjuan, Miguel, Patera, Andriani C., Kolbeck, Roland, Herbst, Ronald, Sims, Gary P.
Publicado 2013

Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells

por Nyborg, Andrew C, Zacco, Anna, Ettinger, Rachel, Jack Borrok, M, Zhu, Jie, Martin, Tom, Woods, Rob, Kiefer, Christine, Bowen, Michael A, Suzanne Cohen, E., Herbst, Ronald, Wu, Herren, Coats, Steven
Publicado 2016

Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency

por Dosch, Joseph, Ziemke, Elizabeth, Wan, Shanshan, Luker, Kathryn, Welling, Theodore, Hardiman, Karin, Fearon, Eric, Thomas, Suneetha, Flynn, Matthew, Rios-Doria, Jonathan, Hollingsworth, Robert, Herbst, Ronald, Hurt, Elaine, Sebolt-Leopold, Judith
Publicado 2017

Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy

por Varkey, Reena, Du, Qun, Karnell, Jodi L., Xiao, Xiaodong, Casey, Kerry A., Woods, Rob, Rosenthal, Kim, Wilson, Susan, Dall’Acqua, William F., Wu, Herren, Herbst, Ronald, Ettinger, Rachel, Damschroder, Melissa
Publicado 2019

Opposing Roles of Membrane and Soluble Forms of the Receptor for Advanced Glycation End Products in Primary Respiratory Syncytial Virus Infection

por Miller, Allison L., Sims, Gary P., Brewah, Yambasu A., Rebelatto, Marlon C., Kearley, Jennifer, Benjamin, Ebony, Keller, Ashley E., Brohawn, Philip, Herbst, Ronald, Coyle, Anthony J., Humbles, Alison A., Kolbeck, Roland
Publicado 2012

Safety and tolerability of an anti-CD19 monoclonal antibody, MEDI-551, in subjects with systemic sclerosis: a phase I, randomized, placebo-controlled, escalating single-dose study

por Schiopu, Elena, Chatterjee, Soumya, Hsu, Vivien, Flor, Armando, Cimbora, Daniel, Patra, Kaushik, Yao, Wenliang, Li, Jing, Streicher, Katie, McKeever, Kathleen, White, Barbara, Katz, Eliezer, Drappa, Jorn, Sweeny, Sarah, Herbst, Ronald
Publicado 2016

Safety and disease response to MEDI-551, an anti-CD19 antibody, in chronic lymphocytic leukemia patients previously treated with rituximab

por Forero, Andres, Hamadani, Mehdi, Kipps, Thomas, Fanale, Michelle, Cuneo, Antonio, Perez de Oteyza, Jaime, Gladstone, Douglas, Andre, Marc, Bellam, Naresh, Goswami, Trishna, Ibrahim, Ramy, Schneider, Amy, Liang, Meina, Eck, Steven, Elgeioushi, Nairouz, Herbst, Ronald, Cheson, Bruce D
Publicado 2013

Role of BAFF in pulmonary autoantibody responses induced by chronic cigarette smoke exposure in mice

por Morissette, Mathieu C., Gao, Yang, Shen, Pamela, Thayaparan, Danya, Bérubé, Jean‐Christophe, Paré, Peter D., Brandsma, Corry‐Anke, Hao, Ke, Bossé, Yohan, Ettinger, Rachel, Herbst, Ronald, Humbles, Alison A., Kolbeck, Roland, Zhong, Nanshan, Chen, Rongchang, Stämpfli, Martin R.
Publicado 2016

S100A9 Induced Inflammatory Responses Are Mediated by Distinct Damage Associated Molecular Patterns (DAMP) Receptors In Vitro and In Vivo

por Chen, Bo, Miller, Allison L., Rebelatto, Marlon, Brewah, Yambasu, Rowe, Daniel C., Clarke, Lori, Czapiga, Meggan, Rosenthal, Kim, Imamichi, Tomozumi, Chen, Yan, Chang, Chew-Shun, Chowdhury, Partha S., Naiman, Brian, Wang, Yue, Yang, De, Humbles, Alison A., Herbst, Ronald, Sims, Gary P.
Publicado 2015

Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies

por Mullins, Stefanie R., Vasilakos, John P., Deschler, Katharina, Grigsby, Iwen, Gillis, Pete, John, Julius, Elder, Matthew J., Swales, John, Timosenko, Elina, Cooper, Zachary, Dovedi, Simon J., Leishman, Andrew J., Luheshi, Nadia, Elvecrog, James, Tilahun, Ashenafi, Goodwin, Richard, Herbst, Ronald, Tomai, Mark A., Wilkinson, Robert W.
Publicado 2019

Self-reactive IgE exacerbates interferon responses associated with autoimmunity

por Henault, Jill, Riggs, Jeffrey M., Karnell, Jodi L., Liarski, Vladimir M., Li, Jianqing, Shirinian, Lena, Xu, Linda, Casey, Kerry A., Smith, Michael A., Khatry, Deepak B., Izhak, Liat, Clarke, Lorraine, Herbst, Ronald, Ettinger, Rachel, Petri, Michelle, Clark, Marcus R., Mustelin, Tomas, Kolbeck, Roland, Sanjuan, Miguel A.
Publicado 2015

Targeting CD73 in the tumor microenvironment with MEDI9447

por Hay, Carl M., Sult, Erin, Huang, Qihui, Mulgrew, Kathy, Fuhrmann, Stacy R., McGlinchey, Kelly A., Hammond, Scott A., Rothstein, Raymond, Rios-Doria, Jonathan, Poon, Edmund, Holoweckyj, Nick, Durham, Nicholas M., Leow, Ching Ching, Diedrich, Gundo, Damschroder, Melissa, Herbst, Ronald, Hollingsworth, Robert E., Sachsenmeier, Kris F.
Publicado 2016

Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer

por Bosco, Emily E., Christie, R. James, Carrasco, Rosa, Sabol, Darrin, Zha, Jiping, DaCosta, Karma, Brown, Lee, Kennedy, Maureen, Meekin, John, Phipps, Sandrina, Ayriss, Joanne, Du, Qun, Bezabeh, Binyam, Chowdhury, Partha, Breen, Shannon, Chen, Cui, Reed, Molly, Hinrichs, MaryJane, Zhong, Haihong, Xiao, Zhan, Dixit, Rakesh, Herbst, Ronald, Tice, David A.
Publicado 2018

The tumor inflammation signature (TIS) is associated with anti-PD-1 treatment benefit in the CERTIM pan-cancer cohort

por Damotte, Diane, Warren, Sarah, Arrondeau, Jennifer, Boudou-Rouquette, Pascaline, Mansuet-Lupo, Audrey, Biton, Jérôme, Ouakrim, Hanane, Alifano, Marco, Gervais, Claire, Bellesoeur, Audrey, Kramkimel, Nora, Tlemsani, Camille, Burroni, Barbara, Duche, Angéline, Letourneur, Franck, Si, Han, Halpin, Rebecca, Creasy, Todd, Herbst, Ronald, Ren, Xing, Morel, Pascale, Cesano, Alessandra, Goldwasser, François, Leroy, Karen
Publicado 2019

Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction

por Nayar, Saba, Pontarini, Elena, Campos, Joana, Berardicurti, Onorina, Smith, Charlotte G., Asam, Saba, Gardner, David H., Colafrancesco, Serena, Lucchesi, Davide, Coleby, Rachel, Chung, Ming-May, Iannizzotto, Valentina, Hunter, Kelly, Bowman, Simon J., Carlesso, Gianluca, Herbst, Ronald, McGettrick, Helen M., Browning, Jeff, Buckley, Christopher D., Fisher, Benjamin A., Bombardieri, Michele, Barone, Francesca
Publicado 2022