Detection of Protein–Small Molecule Binding Using a Self-Referencing External Cavity Laser Biosensor

por Zhang, Meng, Peh, Jessie, Hergenrother, Paul J., Cunningham, Brian T.
Publicado 2014

A Phosphonate Natural Product Made by Pantoea ananatis is Necessary and Sufficient for the Hallmark Lesions of Onion Center Rot

por Polidore, Alexander L. A., Furiassi, Lucia, Hergenrother, Paul J., Metcalf, William W.
Publicado 2021

Txe, an endoribonuclease of the enterococcal Axe–Txe toxin–antitoxin system, cleaves mRNA and inhibits protein synthesis

por Halvorsen, Elizabeth M., Williams, Julia J., Bhimani, Azra J., Billings, Emily A., Hergenrother, Paul J.
Publicado 2011

Dual Small-Molecule Targeting of Procaspase-3 Dramatically Enhances Zymogen Activation and Anticancer Activity

por Botham, Rachel C., Fan, Timothy M., Im, Isak, Borst, Luke B., Dirikolu, Levent, Hergenrother, Paul J.
Publicado 2014

Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics

por Botham, Rachel C., Roth, Howard S., Book, Alison P., Roady, Patrick J., Fan, Timothy M., Hergenrother, Paul J.
Publicado 2016

Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma

por Svec, Riley L., Furiassi, Lucia, Skibinski, Christine G., Fan, Timothy M., Riggins, Gregory J., Hergenrother, Paul J.
Publicado 2018

(ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition

por Rack, Johannes Gregor Matthias, Ariza, Antonio, Drown, Bryon S., Henfrey, Callum, Bartlett, Edward, Shirai, Tomohiro, Hergenrother, Paul J., Ahel, Ivan
Publicado 2018

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

por Llabani, Evijola, Hicklin, Robert W., Lee, Hyang Yeon, Motika, Stephen E., Crawford, Lisa A., Weerapana, Eranthie, Hergenrother, Paul J.
Publicado 2019

Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens

por Parker, Erica N., Drown, Bryon S., Geddes, Emily J., Lee, Hyang Yeon, Ismail, Nahed, Lau, Gee W., Hergenrother, Paul J.
Publicado 2019

Targeting multidrug-resistant ovarian cancer through estrogen receptor α dependent ATP depletion caused by hyperactivation of the unfolded protein response

por Zheng, Xiaobin, Andruska, Neal, Lambrecht, Michael J., He, Sisi, Parissenti, Amadeo, Hergenrother, Paul J., Nelson, Erik R., Shapiro, David J.
Publicado 2016

Rationalizing the generation of broad spectrum antibiotics with the addition of a positive charge

por Haloi, Nandan, Vasan, Archit Kumar, Geddes, Emily J., Prasanna, Arjun, Wen, Po-Chao, Metcalf, William W., Hergenrother, Paul J., Tajkhorshid, Emad
Publicado 2021

A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain

por Anmangandla, Ananya, Jana, Sadhan, Peng, Kewen, Wallace, Shamar D., Bagde, Saket R., Drown, Bryon S., Xu, Jiashu, Hergenrother, Paul J., Fromme, J. Christopher, Lin, Hening
Publicado 2023

Role of internal loop dynamics in antibiotic permeability of outer membrane porins

por Vasan, Archit Kumar, Haloi, Nandan, Ulrich, Rebecca Joy, Metcalf, Mary Elizabeth, Wen, Po-Chao, Metcalf, William W., Hergenrother, Paul J., Shukla, Diwakar, Tajkhorshid, Emad
Publicado 2022

Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria

por Parkinson, Elizabeth I., Bair, Joseph S., Nakamura, Bradley A., Lee, Hyang Y., Kuttab, Hani I., Southgate, Emma H., Lezmi, Stéphane, Lau, Gee W., Hergenrother, Paul J.
Publicado 2015

Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins

por Thirawatananond, Puchong, McPherson, Robert Lyle, Malhi, Jasmine, Nathan, Sara, Lambrecht, Michael J., Brichacek, Matthew, Hergenrother, Paul J., Leung, Anthony K. L., Gabelli, Sandra B.
Publicado 2019

OR16-06 A Novel Pathway Controlling Anticancer Drug Induced Immunogenic Necrosis In ERα Positive Cancer Cells

por Zhu, Junyao, Ghosh, Santanu, Duraki, Darjan, Boudreau, Matthew, Jabeen, Musarrat, Mao, Chengjian, Park, Ben Ho, Cheng, Georgina, Nelson, Erik Russell, Hergenrother, Paul J, Shapiro, David J
Publicado 2023

Immunohistochemical Characterization of Procaspase-3 Overexpression as a Druggable Target With PAC-1, a Procaspase-3 Activator, in Canine and Human Brain Cancers

por Schlein, Lisa J., Fadl-Alla, Bahaa, Pondenis, Holly C., Lezmi, Stéphane, Eberhart, Charles G., LeBlanc, Amy K., Dickinson, Peter J., Hergenrother, Paul J., Fan, Timothy M.
Publicado 2019

Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy

por Lundberg, Alycen P., Boudreau, Matthew W., Selting, Kim A., Chatkewitz, Lindsay E., Samuelson, Jonathan, Francis, Joshua M., Parkinson, Elizabeth I., Barger, Anne M., Hergenrother, Paul J., Fan, Timothy M.
Publicado 2021

OR05-05 Lethal ERα-Dependent Hyperactivation of the Unfolded Protein Response Induces Complete Regression Without Recurrence of Primary and Metastatic Breast Cancer

por Duraki, Darjan, Boudreau, Matthew W, Wang, Lawrence, Mao, Chengjian, Tang, Bingtao, Ma, Liqian, Roy, Edward J, Fan, Timothy M, Park, Ben Ho, Nelson, Erik R, Hergenrother, Paul J, Shapiro, David J
Publicado 2020

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant gliom...

por Joshi, Avadhut D., Botham, Rachel C., Schlein, Lisa J., Roth, Howard S., Mangraviti, Antonella, Borodovsky, Alexandra, Tyler, Betty, Joslyn, Steve, Looper, Jayme S., Podell, Michael, Fan, Timothy M., Hergenrother, Paul J., Riggins, Gregory J.
Publicado 2017