Use of imaging to assess the activity of hepatic transporters

por Hernández Lozano, Irene, Langer, Oliver
Publicado 2020

Imaging-Based Characterization of a Slco2b1((-/-)) Mouse Model Using [(11)C]Erlotinib and [(99m)Tc]Mebrofenin as Probe Substrates

por Marie, Solène, Hernández-Lozano, Irene, Breuil, Louise, Truillet, Charles, Hu, Shuiying, Sparreboom, Alex, Tournier, Nicolas, Langer, Oliver
Publicado 2021

Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography

por Hernández Lozano, Irene, Karch, Rudolf, Bauer, Martin, Blaickner, Matthias, Matsuda, Akihiro, Wulkersdorfer, Beatrix, Hacker, Marcus, Zeitlinger, Markus, Langer, Oliver
Publicado 2019

Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [(11)C]Metoclopramide in Mice

por Hernández-Lozano, Irene, Mairinger, Severin, Sauberer, Michael, Stanek, Johann, Filip, Thomas, Wanek, Thomas, Ciarimboli, Giuliano, Tournier, Nicolas, Langer, Oliver
Publicado 2021

Assessing the Functional Redundancy between P-gp and BCRP in Controlling the Brain Distribution and Biliary Excretion of Dual Substrates with PET Imaging in Mice

por Hernández-Lozano, Irene, Mairinger, Severin, Traxl, Alexander, Sauberer, Michael, Filip, Thomas, Stanek, Johann, Kuntner, Claudia, Wanek, Thomas, Langer, Oliver
Publicado 2021

Validation of Pharmacological Protocols for Targeted Inhibition of Canalicular MRP2 Activity in Hepatocytes Using [(99m)Tc]mebrofenin Imaging in Rats

por Marie, Solène, Hernández-Lozano, Irene, Breuil, Louise, Saba, Wadad, Novell, Anthony, Gennisson, Jean-Luc, Langer, Oliver, Truillet, Charles, Tournier, Nicolas
Publicado 2020

Pharmacokinetic Imaging Using (99m)Tc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats

por Marie, Solène, Hernández-Lozano, Irene, Le Vée, Marc, Breuil, Louise, Saba, Wadad, Goislard, Maud, Goutal, Sébastien, Truillet, Charles, Langer, Oliver, Fardel, Olivier, Tournier, Nicolas
Publicado 2022

Use of PET Imaging to Assess the Efficacy of Thiethylperazine to Stimulate Cerebral MRP1 Transport Activity in Wild-Type and APP/PS1-21 Mice

por Wölfl-Duchek, Michael, Mairinger, Severin, Hernández-Lozano, Irene, Filip, Thomas, Zoufal, Viktoria, Löbsch, Mathilde, Stanek, Johann, Kuntner, Claudia, Wanek, Thomas, Bauer, Martin, Pahnke, Jens, Langer, Oliver
Publicado 2022