Cell Heterogeneity and Paracrine Interactions in Human Islet Function: A Perspective Focused in β-Cell Regeneration Strategies

por Bru-Tari, Eva, Oropeza, Daniel, Herrera, Pedro L.
Publicado 2021

K(ATP) channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca(2+)](c) rise and an indirect inhibition mediated by somat...

por Singh, Bilal, Khattab, Firas, Chae, Heeyoung, Desmet, Lieven, Herrera, Pedro L., Gilon, Patrick
Publicado 2021

Conversion of Adult Pancreatic α-cells to β-cells After Extreme β-cell Loss

por Thorel, Fabrizio, Népote, Virginie, Avril, Isabelle, Kohno, Kenji, Desgraz, Renaud, Chera, Simona, Herrera, Pedro L.
Publicado 2010

Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss

por Oropeza, Daniel, Cigliola, Valentina, Romero, Agustín, Chera, Simona, Rodríguez-Seguí, Santiago A., Herrera, Pedro L.
Publicado 2021

Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes

por Bhagchandani, Preksha, Chang, Charles A., Zhao, Weichen, Ghila, Luiza, Herrera, Pedro L., Chera, Simona, Kim, Seung K.
Publicado 2022

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

por Thorel, Fabrizio, Damond, Nicolas, Chera, Simona, Wiederkehr, Andreas, Thorens, Bernard, Meda, Paolo, Wollheim, Claes B., Herrera, Pedro L.
Publicado 2011

In Situ Electrophysiological Examination of Pancreatic α Cells in the Streptozotocin-Induced Diabetes Model, Revealing the Cellular Basis of Glucagon Hypersecretion

por Huang, Ya-Chi, Rupnik, Marjan S., Karimian, Negar, Herrera, Pedro L., Gilon, Patrick, Feng, Zhong-Ping, Gaisano, Herbert Y.
Publicado 2013

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist

por Damond, Nicolas, Thorel, Fabrizio, Moyers, Julie S, Charron, Maureen J, Vuguin, Patricia M, Powers, Alvin C, Herrera, Pedro L
Publicado 2016

Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes

por van Krieken, Pim P., Dicker, Andrea, Eriksson, Maria, Herrera, Pedro L., Ahlgren, Ulf, Berggren, Per-Olof, Ilegems, Erwin
Publicado 2017

Adult pancreatic islet endocrine cells emerge as fetal hormone-expressing cells

por Perez-Frances, Marta, Abate, Maria Valentina, Baronnier, Delphine, Scherer, Philipp E., Fujitani, Yoshio, Thorel, Fabrizio, Herrera, Pedro L.
Publicado 2022

Nogo-A Downregulation Improves Insulin Secretion in Mice

por Bonal, Claire B., Baronnier, Delphine E., Pot, Caroline, Benkhoucha, Mahdia, Schwab, Martin E., Lalive, Patrice H., Herrera, Pedro L.
Publicado 2013

Loss of Prohibitin Induces Mitochondrial Damages Altering β-Cell Function and Survival and Is Responsible for Gradual Diabetes Development

por Supale, Sachin, Thorel, Fabrizio, Merkwirth, Carsten, Gjinovci, Asllan, Herrera, Pedro L., Scorrano, Luca, Meda, Paolo, Langer, Thomas, Maechler, Pierre
Publicado 2013

Connective Tissue Growth Factor Modulates Adult β-Cell Maturity and Proliferation to Promote β-Cell Regeneration in Mice

por Riley, Kimberly G., Pasek, Raymond C., Maulis, Matthew F., Peek, Jennifer, Thorel, Fabrizio, Brigstock, David R., Herrera, Pedro L., Gannon, Maureen
Publicado 2015

The Transcription Factor Rfx3 Regulates β-Cell Differentiation, Function, and Glucokinase Expression

por Ait-Lounis, Aouatef, Bonal, Claire, Seguín-Estévez, Queralt, Schmid, Christoph D., Bucher, Philipp, Herrera, Pedro L., Durand, Bénédicte, Meda, Paolo, Reith, Walter
Publicado 2010

Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD–scid IL-2rg(null) RIP-DTR mice engrafted wi...

por Yang, Chaoxing, Loehn, Matthias, Jurczyk, Agata, Przewozniak, Natalia, Leehy, Linda, Herrera, Pedro L, Shultz, Leonard D, Greiner, Dale L, Harlan, David M, Bortell, Rita
Publicado 2015

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion

por Solomou, Antonia, Meur, Gargi, Bellomo, Elisa, Hodson, David J., Tomas, Alejandra, Migrenne Li, Stéphanie, Philippe, Erwann, Herrera, Pedro L., Magnan, Christophe, Rutter, Guy A.
Publicado 2015

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells

por Paul, Leena, Walker, Emily M., Drosos, Yiannis, Cyphert, Holly A., Neale, Geoffrey, Stein, Roland, South, Jack, Grosveld, Gerard, Herrera, Pedro L., Sosa-Pineda, Beatriz
Publicado 2016

Generation of human islet cell type-specific identity genesets

por van Gurp, Léon, Fodoulian, Leon, Oropeza, Daniel, Furuyama, Kenichiro, Bru-Tari, Eva, Vu, Anh Nguyet, Kaddis, John S., Rodríguez, Iván, Thorel, Fabrizio, Herrera, Pedro L.
Publicado 2022

Dicer Is Required for Haploid Male Germ Cell Differentiation in Mice

por Korhonen, Hanna M., Meikar, Oliver, Yadav, Ram Prakash, Papaioannou, Marilena D., Romero, Yannick, Da Ros, Matteo, Herrera, Pedro L., Toppari, Jorma, Nef, Serge, Kotaja, Noora
Publicado 2011

Diabetes Recovery By Age-Dependent Conversion of Pancreatic δ-Cells Into Insulin Producers

por Chera, Simona, Baronnier, Delphine, Ghila, Luiza, Cigliola, Valentina, Jensen, Jan N., Gu, Guoqiang, Furuyama, Kenichiro, Thorel, Fabrizio, Gribble, Fiona M., Reimann, Frank, Herrera, Pedro L.
Publicado 2014