FoxA factors: the chromatin key and doorstop essential for liver development and function

por Heslop, James A., Duncan, Stephen A.
Publicado 2020

Chromatin remodeling is restricted by transient GATA6 binding during iPSC differentiation to definitive endoderm

por Heslop, James A., Pournasr, Behshad, Duncan, Stephen A.
Publicado 2022

GATA6 defines endoderm fate by controlling chromatin accessibility during differentiation of human-induced pluripotent stem cells

por Heslop, James A., Pournasr, Behshad, Liu, Jui-Tung, Duncan, Stephen A.
Publicado 2021

Enhanced genome editing in human iPSCs with CRISPR-CAS9 by co-targeting ATP1a1

por Liu, Jui-Tung, Corbett, James L., Heslop, James A., Duncan, Stephen A.
Publicado 2020

PDE5 inhibition rescues mitochondrial dysfunction and angiogenic responses induced by Akt3 inhibition by promotion of PRC expression

por Corum, Daniel G., Jenkins, Dorea P., Heslop, James A., Tallent, Lacey M., Beeson, Gyda C., Barth, Jeremy L., Schnellmann, Rick G., Muise-Helmericks, Robin C.
Publicado 2021

Donor‐Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte‐Like Ce...

por Heslop, James A., Kia, Richard, Pridgeon, Christopher S., Sison‐Young, Rowena L., Liloglou, Triantafillos, Elmasry, Mohamed, Fenwick, Stephen W., Mills, John S., Kitteringham, Neil R., Goldring, Chris E., Park, Bong K.
Publicado 2017

A human iPSC-derived hepatocyte screen identifies compounds that inhibit production of Apolipoprotein B

por Liu, Jui-Tung, Doueiry, Caren, Jiang, Yu-lin, Blaszkiewicz, Josef, Lamprecht, Mary Paige, Heslop, James A., Peterson, Yuri K., Carten, Juliana Debrito, Traktman, Paula, Yuan, Yang, Khetani, Salman R., Twal, Waleed O., Duncan, Stephen A.
Publicado 2023

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

por Heslop, James A., Rowe, Cliff, Walsh, Joanne, Sison-Young, Rowena, Jenkins, Roz, Kamalian, Laleh, Kia, Richard, Hay, David, Jones, Robert P., Malik, Hassan Z., Fenwick, Stephen, Chadwick, Amy E., Mills, John, Kitteringham, Neil R., Goldring, Chris E. P., Kevin Park, B.
Publicado 2016

MicroRNA-122: A Novel Hepatocyte-Enriched in vitro Marker of Drug-Induced Cellular Toxicity

por Kia, Richard, Kelly, Lorna, Sison-Young, Rowena L. C., Zhang, Fang, Pridgeon, Chris S., Heslop, James A., Metcalfe, Pete, Kitteringham, Neil R., Baxter, Melissa, Harrison, Sean, Hanley, Neil A., Burke, Zoë D., Storm, Mike P., Welham, Melanie J., Tosh, David, Küppers-Munther, Barbara, Edsbagge, Josefina, Starkey Lewis, Philip J., Bonner, Frank, Harpur, Ernie, Sidaway, James, Bowes, Joanne, Fenwick, Stephen W., Malik, Hassan, Goldring, Chris E. P., Park, B. Kevin
Publicado 2015

FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

por Brevini, Teresa, Maes, Mailis, Webb, Gwilym J., John, Binu V., Fuchs, Claudia D., Buescher, Gustav, Wang, Lu, Griffiths, Chelsea, Brown, Marnie L., Scott, William E., Pereyra-Gerber, Pehuén, Gelson, William T. H., Brown, Stephanie, Dillon, Scott, Muraro, Daniele, Sharp, Jo, Neary, Megan, Box, Helen, Tatham, Lee, Stewart, James, Curley, Paul, Pertinez, Henry, Forrest, Sally, Mlcochova, Petra, Varankar, Sagar S., Darvish-Damavandi, Mahnaz, Mulcahy, Victoria L., Kuc, Rhoda E., Williams, Thomas L., Heslop, James A., Rossetti, Davide, Tysoe, Olivia C., Galanakis, Vasileios, Vila-Gonzalez, Marta, Crozier, Thomas W. M., Bargehr, Johannes, Sinha, Sanjay, Upponi, Sara S., Fear, Corrina, Swift, Lisa, Saeb-Parsy, Kourosh, Davies, Susan E., Wester, Axel, Hagström, Hannes, Melum, Espen, Clements, Darran, Humphreys, Peter, Herriott, Jo, Kijak, Edyta, Cox, Helen, Bramwell, Chloe, Valentijn, Anthony, Illingworth, Christopher J. R., Dahman, Bassam, Bastaich, Dustin R., Ferreira, Raphaella D., Marjot, Thomas, Barnes, Eleanor, Moon, Andrew M., Barritt, Alfred S., Gupta, Ravindra K., Baker, Stephen, Davenport, Anthony P., Corbett, Gareth, Gorgoulis, Vassilis G., Buczacki, Simon J. A., Lee, Joo-Hyeon, Matheson, Nicholas J., Trauner, Michael, Fisher, Andrew J., Gibbs, Paul, Butler, Andrew J., Watson, Christopher J. E., Mells, George F., Dougan, Gordon, Owen, Andrew, Lohse, Ansgar W., Vallier, Ludovic, Sampaziotis, Fotios
Publicado 2022