Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

por Han, Kyuho, Jeng, Edwin E., Hess, Gaelen T., Morgens, David W., Li, Amy, Bassik, Michael C.
Publicado 2017

Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform

por Siepe, Dirk H, Henneberg, Lukas T, Wilson, Steven C, Hess, Gaelen T, Bassik, Michael C, Zinn, Kai, Garcia, K Christopher
Publicado 2022

Roadmap for the use of base editors to decipher drug mechanism of action

por Aparicio-Prat, Estel, Yan, Dong, Mariotti, Marco, Bassik, Michael, Hess, Gaelen, Fortin, Jean-Philippe, Weston, Andrea, Xi, Hualin S., Stanton, Robert
Publicado 2021

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies

por Breslow, David K., Hoogendoorn, Sascha, Kopp, Adam R., Morgens, David W., Vu, Brandon K., Kennedy, Margaret C., Han, Kyuho, Li, Amy, Hess, Gaelen T., Bassik, Michael C., Chen, James K., Nachury, Maxence V.
Publicado 2018

Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

por Morgens, David W., Wainberg, Michael, Boyle, Evan A., Ursu, Oana, Araya, Carlos L., Tsui, C. Kimberly, Haney, Michael S., Hess, Gaelen T., Han, Kyuho, Jeng, Edwin E., Li, Amy, Snyder, Michael P., Greenleaf, William J., Kundaje, Anshul, Bassik, Michael C.
Publicado 2017

The impact of rare variation on gene expression across tissues

por Li, Xin, Kim, Yungil, Tsang, Emily K., Davis, Joe R., Damani, Farhan N., Chiang, Colby, Hess, Gaelen T., Zappala, Zachary, Strober, Benjamin J., Scott, Alexandra J., Li, Amy, Ganna, Andrea, Bassik, Michael C., Merker, Jason D., Hall, Ira M., Battle, Alexis, Montgomery, Stephen B.
Publicado 2017

Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

por Morgens, David W, Chan, Charlene, Kane, Andrew J, Weir, Nicholas R, Li, Amy, Dubreuil, Michael M, Tsui, C Kimberly, Hess, Gaelen T, Lavertu, Adam, Han, Kyuho, Polyakov, Nicole, Zhou, Jing, Handy, Emma L, Alabi, Philip, Dombroski, Amanda, Yao, David, Altman, Russ B, Sello, Jason K, Denic, Vladimir, Bassik, Michael C
Publicado 2019

Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements

por Tycko, Josh, Wainberg, Michael, Marinov, Georgi K., Ursu, Oana, Hess, Gaelen T., Ego, Braeden K., Aradhana, Li, Amy, Truong, Alisa, Trevino, Alexandro E., Spees, Kaitlyn, Yao, David, Kaplow, Irene M., Greenside, Peyton G., Morgens, David W., Phanstiel, Douglas H., Snyder, Michael P., Bintu, Lacramioara, Greenleaf, William J., Kundaje, Anshul, Bassik, Michael C.
Publicado 2019

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

por Debets, Marjoke F., Tastan, Omur Y., Wisnovsky, Simon P., Malaker, Stacy A., Angelis, Nikolaos, Moeckl, Leonhard K. R., Choi, Junwon, Flynn, Helen, Wagner, Lauren J. S., Bineva-Todd, Ganka, Antonopoulos, Aristotelis, Cioce, Anna, Browne, William M., Li, Zhen, Briggs, David C., Douglas, Holly L., Hess, Gaelen T., Agbay, Anthony J., Roustan, Chloe, Kjaer, Svend, Haslam, Stuart M., Snijders, Ambrosius P., Bassik, Michael C., Moerner, W. E., Li, Vivian S. W., Bertozzi, Carolyn R., Schumann, Benjamin
Publicado 2020