Nonhuman primate models of asthma

por Coffman, Robert L., Hessel, Edith M.
Publicado 2005

PI3K inhibitors in inflammation, autoimmunity and cancer

por Stark, Anne-Katrien, Sriskantharajah, Srividya, Hessel, Edith M, Okkenhaug, Klaus
Publicado 2015

Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat...

por Edwards, Chris D., Luscombe, Chris, Eddershaw, Peter, Hessel, Edith M.
Publicado 2016

Predicting Re-Exacerbation Timing and Understanding Prolonged Exacerbations: An Analysis of Patients with COPD in the ECLIPSE Cohort

por Meeraus, Wilhelmine H, Mullerova, Hana, El Baou, Céline, Fahey, Marion, Hessel, Edith M, Fahy, William A
Publicado 2021

Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages

por Lopes, Filipa B., Bálint, Štefan, Valvo, Salvatore, Felce, James H., Hessel, Edith M., Dustin, Michael L., Davis, Daniel M.
Publicado 2017

The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages

por Lea, Simon R, Reynolds, Sophie L, Kaur, Manminder, Simpson, Karen D, Hall, Simon R, Hessel, Edith M, Singh, Dave
Publicado 2018

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

por Aegerter, Helena, Kulikauskaite, Justina, Crotta, Stefania, Patel, Harshil, Kelly, Gavin, Hessel, Edith M., Mack, Matthias, Beinke, Soren, Wack, Andreas
Publicado 2020

IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment

por Davidson, Sophia, McCabe, Teresa M, Crotta, Stefania, Gad, Hans Henrik, Hessel, Edith M, Beinke, Soren, Hartmann, Rune, Wack, Andreas
Publicado 2016

Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction

por Hessel, Edith M., Chu, Mabel, Lizcano, Jennifer O., Chang, Bonnie, Herman, Nancy, Kell, Sariah A., Wills-Karp, Marsha, Coffman, Robert L.
Publicado 2005

PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation

por Uddin, Sorif, Amour, Augustin, Lewis, David J., Edwards, Chris D., Williamson, Matthew G., Hall, Simon, Lione, Lisa A., Hessel, Edith M.
Publicado 2021

Ampicillin resistance in Haemophilus influenzae from COPD patients in the UK

por Maddi, Satyanarayana, Kolsum, Umme, Jackson, Sarah, Barraclough, Richard, Maschera, Barbara, Simpson, Karen D, Pascal, Thierry G, Durviaux, Serge, Hessel, Edith M, Singh, Dave
Publicado 2017

Airway host-microbiome interactions in chronic obstructive pulmonary disease

por Wang, Zhang, Maschera, Barbara, Lea, Simon, Kolsum, Umme, Michalovich, David, Van Horn, Stephanie, Traini, Christopher, Brown, James R., Hessel, Edith M., Singh, Dave
Publicado 2019

Corrected Super-Resolution Microscopy Enables Nanoscale Imaging of Autofluorescent Lung Macrophages

por Ambrose, Ashley R., Dechantsreiter, Susanne, Shah, Rajesh, Montero, M. Angeles, Quinn, Anne Marie, Hessel, Edith M., Beinke, Soren, Tannahill, Gillian M., Davis, Daniel M.
Publicado 2020

Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption

por Miller, Neil A., Graves, Rebecca H., Edwards, Chris D., Amour, Augustin, Taylor, Ed, Robb, Olivia, O’Brien, Brett, Patel, Aarti, Harrell, Andrew W., Hessel, Edith M.
Publicado 2021

Intranasal Bifidobacterium longum protects against viral-induced lung inflammation and injury in a murine model of lethal influenza infection

por Groeger, David, Schiavi, Elisa, Grant, Ray, Kurnik-Łucka, Magdalena, Michalovich, David, Williamson, Rick, Beinke, Soren, Kiely, Barry, Akdis, Cezmi A, Hessel, Edith M, Shanahan, Fergus, O’ Mahony, Liam
Publicado 2020

Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study

por Fahy, William A, Homayoun-Valiani, Farshid, Cahn, Anthony, Robertson, Jon, Templeton, Alison, Meeraus, Wilhelmine H, Wilson, Robert, Lowings, Mike, Marotti, Miriam, West, Sarah L, Tabberer, Maggie, Hessel, Edith M
Publicado 2021

Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures

por Wronski, Sabine, Beinke, Soren, Obernolte, Helena, Belyaev, Nikolai N., Saunders, Ken A., Lennon, Mark G., Schaudien, Dirk, Braubach, Peter, Jonigk, Danny, Warnecke, Gregor, Zardo, Patrick, Fieguth, Hans-Gerd, Wilkens, Ludwig, Braun, Armin, Hessel, Edith M.
Publicado 2021

Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage

por Lima, Braulio Henrique Freire, Marques, Pedro Elias, Gomides, Lindisley Ferreira, Mattos, Matheus Silvério, Kraemer, Lucas, Queiroz-Junior, Celso M., Lennon, Mark, Hirsch, Emilio, Russo, Remo Castro, Menezes, Gustavo Batista, Hessel, Edith M., Amour, Augustin, Teixeira, Mauro Martins
Publicado 2019

An Inhaled PI3Kδ Inhibitor Improves Recovery in Acutely Exacerbating COPD Patients: A Randomized Trial

por Cahn, Anthony, Hamblin, J Nicole, Robertson, Jon, Begg, Malcolm, Jarvis, Emily, Wilson, Robert, Dear, Gordon, Leemereise, Claudia, Cui, Yi, Mizuma, Maki, Montembault, Mickael, Van Holsbeke, Cedric, Vos, Wim, De Backer, Wilfried, De Backer, Jan, Hessel, Edith M
Publicado 2021

PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

por Stark, Anne-Katrien, Chandra, Anita, Chakraborty, Krishnendu, Alam, Rafeah, Carbonaro, Valentina, Clark, Jonathan, Sriskantharajah, Srividya, Bradley, Glyn, Richter, Alex G., Banham-Hall, Edward, Clatworthy, Menna R., Nejentsev, Sergey, Hamblin, J. Nicole, Hessel, Edith M., Condliffe, Alison M., Okkenhaug, Klaus
Publicado 2018