FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organizat...

por Heuer, Timothy S., Ventura, Richard, Mordec, Kasia, Lai, Julie, Fridlib, Marina, Buckley, Douglas, Kemble, George
Publicado 2016

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gen...

por Ventura, Richard, Mordec, Kasia, Waszczuk, Joanna, Wang, Zhaoti, Lai, Julie, Fridlib, Marina, Buckley, Douglas, Kemble, George, Heuer, Timothy S.
Publicado 2015

Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer

por Zaytseva, Yekaterina Y., Rychahou, Piotr G., Le, Anh-Thu, Scott, Timothy L., Flight, Robert M., Kim, Ji Tae, Harris, Jennifer, Liu, Jinpeng, Wang, Chi, Morris, Andrew J., Sivakumaran, Theru A., Fan, Teresa, Moseley, Hunter, Gao, Tianyan, Lee, Eun Y., Weiss, Heidi L., Heuer, Timothy S., Kemble, George, Evers, Mark
Publicado 2018