Immuno-inflammatory in vitro hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin

por Roser, Luise A., Luckhardt, Sonja, Ziegler, Nicole, Thomas, Dominique, Wagner, Pia Viktoria, Damm, Georg, Scheffschick, Andrea, Hewitt, Philip, Parnham, Michael J., Schiffmann, Susanne
Publicado 2023

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

por Dragovic, Sanja, Vermeulen, Nico P. E., Gerets, Helga H., Hewitt, Philip G., Ingelman‐Sundberg, Magnus, Park, B. Kevin, Juhila, Satu, Snoeys, Jan, Weaver, Richard J.
Publicado 2016

Reproducibility and Robustness of a Liver Microphysiological System PhysioMimix LC12 under Varying Culture Conditions and Cell Type Combinations

por Lim, Alicia Y., Kato, Yuki, Sakolish, Courtney, Valdiviezo, Alan, Han, Gang, Bajaj, Piyush, Stanko, Jason, Ferguson, Stephen S., Villenave, Remi, Hewitt, Philip, Hardwick, Rhiannon N., Rusyn, Ivan
Publicado 2023

Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans

por Atienzar, Franck A., Blomme, Eric A., Chen, Minjun, Hewitt, Philip, Kenna, J. Gerry, Labbe, Gilles, Moulin, Frederic, Pognan, Francois, Roth, Adrian B., Suter-Dick, Laura, Ukairo, Okechukwu, Weaver, Richard J., Will, Yvonne, Dambach, Donna M.
Publicado 2016

Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina

por Dorgau, Birthe, Georgiou, Maria, Chaudhary, Alexander, Moya-Molina, Marina, Collin, Joseph, Queen, Rachel, Hilgen, Gerrit, Davey, Tracey, Hewitt, Philip, Schmitt, Michael, Kustermann, Stefan, Pognan, Francois, Steel, David H, Sernagor, Evelyne, Armstrong, Lyle, Lako, Majlinda
Publicado 2022

The evolving role of investigative toxicology in the pharmaceutical industry

por Pognan, Francois, Beilmann, Mario, Boonen, Harrie C. M., Czich, Andreas, Dear, Gordon, Hewitt, Philip, Mow, Tomas, Oinonen, Teija, Roth, Adrian, Steger-Hartmann, Thomas, Valentin, Jean-Pierre, Van Goethem, Freddy, Weaver, Richard J., Newham, Peter
Publicado 2023

Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoids

por Chichagova, Valeria, Georgiou, Maria, Carter, Madeleine, Dorgau, Birthe, Hilgen, Gerrit, Collin, Joseph, Queen, Rachel, Chung, Git, Ajeian, Jila, Moya‐Molina, Marina, Kustermann, Stefan, Pognan, Francois, Hewitt, Philip, Schmitt, Michael, Sernagor, Evelyne, Armstrong, Lyle, Lako, Majlinda
Publicado 2023

Human‐Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient‐Dependent Efficiency

por Hallam, Dean, Hilgen, Gerrit, Dorgau, Birthe, Zhu, Lili, Yu, Min, Bojic, Sanja, Hewitt, Philip, Schmitt, Michael, Uteng, Marianne, Kustermann, Stefan, Steel, David, Nicholds, Mike, Thomas, Robert, Treumann, Achim, Porter, Andrew, Sernagor, Evelyne, Armstrong, Lyle, Lako, Majlinda
Publicado 2018

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and De...

por Sison-Young, Rowena L. C., Mitsa, Dimitra, Jenkins, Rosalind E., Mottram, David, Alexandre, Eliane, Richert, Lysiane, Aerts, Hélène, Weaver, Richard J., Jones, Robert P., Johann, Esther, Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Christopher E. P., Kitteringham, Neil R., Park, B. Kevin
Publicado 2015

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

por Sison-Young, Rowena L., Lauschke, Volker M., Johann, Esther, Alexandre, Eliane, Antherieu, Sébastien, Aerts, Hélène, Gerets, Helga H. J., Labbe, Gilles, Hoët, Delphine, Dorau, Martina, Schofield, Christopher A., Lovatt, Cerys A., Holder, Julie C., Stahl, Simone H., Richert, Lysiane, Kitteringham, Neil R., Jones, Robert P., Elmasry, Mohamed, Weaver, Richard J., Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Chris E., Park, B. Kevin
Publicado 2016

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of...

por Godoy, Patricio, Hewitt, Nicola J., Albrecht, Ute, Andersen, Melvin E., Ansari, Nariman, Bhattacharya, Sudin, Bode, Johannes Georg, Bolleyn, Jennifer, Borner, Christoph, Böttger, Jan, Braeuning, Albert, Budinsky, Robert A., Burkhardt, Britta, Cameron, Neil R., Camussi, Giovanni, Cho, Chong-Su, Choi, Yun-Jaie, Craig Rowlands, J., Dahmen, Uta, Damm, Georg, Dirsch, Olaf, Donato, María Teresa, Dong, Jian, Dooley, Steven, Drasdo, Dirk, Eakins, Rowena, Ferreira, Karine Sá, Fonsato, Valentina, Fraczek, Joanna, Gebhardt, Rolf, Gibson, Andrew, Glanemann, Matthias, Goldring, Chris E. P., Gómez-Lechón, María José, Groothuis, Geny M. M., Gustavsson, Lena, Guyot, Christelle, Hallifax, David, Hammad, Seddik, Hayward, Adam, Häussinger, Dieter, Hellerbrand, Claus, Hewitt, Philip, Hoehme, Stefan, Holzhütter, Hermann-Georg, Houston, J. Brian, Hrach, Jens, Ito, Kiyomi, Jaeschke, Hartmut, Keitel, Verena, Kelm, Jens M., Kevin Park, B., Kordes, Claus, Kullak-Ublick, Gerd A., LeCluyse, Edward L., Lu, Peng, Luebke-Wheeler, Jennifer, Lutz, Anna, Maltman, Daniel J., Matz-Soja, Madlen, McMullen, Patrick, Merfort, Irmgard, Messner, Simon, Meyer, Christoph, Mwinyi, Jessica, Naisbitt, Dean J., Nussler, Andreas K., Olinga, Peter, Pampaloni, Francesco, Pi, Jingbo, Pluta, Linda, Przyborski, Stefan A., Ramachandran, Anup, Rogiers, Vera, Rowe, Cliff, Schelcher, Celine, Schmich, Kathrin, Schwarz, Michael, Singh, Bijay, Stelzer, Ernst H. K., Stieger, Bruno, Stöber, Regina, Sugiyama, Yuichi, Tetta, Ciro, Thasler, Wolfgang E., Vanhaecke, Tamara, Vinken, Mathieu, Weiss, Thomas S., Widera, Agata, Woods, Courtney G., Xu, Jinghai James, Yarborough, Kathy M., Hengstler, Jan G.
Publicado 2013