Characterisation of light responses in the retina of mice lacking principle components of rod, cone and melanopsin phototransduction signalling pathways

por Hughes, Steven, Rodgers, Jessica, Hickey, Doron, Foster, Russell G., Peirson, Stuart N., Hankins, Mark W.
Publicado 2016

Using siRNA to define functional interactions between melanopsin and multiple G Protein partners

por Hughes, Steven, Jagannath, Aarti, Hickey, Doron, Gatti, Silvia, Wood, Matthew, Peirson, Stuart N., Foster, Russell G., Hankins, Mark W.
Publicado 2014

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

por Salvetti, Anna P., Patrício, Maria I., Barnard, Alun R., Orlans, Harry O., Hickey, Doron G., MacLaren, Robert E.
Publicado 2017

Defining the impact of melanopsin missense polymorphisms using in vivo functional rescue

por Rodgers, Jessica, Hughes, Steven, Pothecary, Carina A, Brown, Laurence A, Hickey, Doron G, Peirson, Stuart N, Hankins, Mark W
Publicado 2018

Chimeric human opsins as optogenetic light sensitisers

por Hickey, Doron G., Davies, Wayne I. L., Hughes, Steven, Rodgers, Jessica, Thavanesan, Navamayooran, MacLaren, Robert E., Hankins, Mark W.
Publicado 2021

ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration

por Gilhooley, Michael J., Hickey, Doron G., Lindner, Moritz, Palumaa, Teele, Hughes, Steven, Peirson, Stuart N., MacLaren, Robert E., Hankins, Mark W.
Publicado 2021

Codon-Optimized RPGR Improves Stability and Efficacy of AAV8 Gene Therapy in Two Mouse Models of X-Linked Retinitis Pigmentosa

por Fischer, M. Dominik, McClements, Michelle E., Martinez-Fernandez de la Camara, Cristina, Bellingrath, Julia-Sophia, Dauletbekov, Daniyar, Ramsden, Simon C., Hickey, Doron G., Barnard, Alun R., MacLaren, Robert E.
Publicado 2017

AAV2-mediated gene therapy for Bietti crystalline dystrophy provides functional CYP4V2 in multiple relevant cell models

por Wang, Jiang-Hui, Lidgerwood, Grace E., Daniszewski, Maciej, Hu, Monica L., Roberts, Georgina E., Wong, Raymond C. B., Hung, Sandy S. C., McClements, Michelle E., Hewitt, Alex W., Pébay, Alice, Hickey, Doron G., Edwards, Thomas L.
Publicado 2022