A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF

por Lightwood, Daniel J., Munro, Rebecca J., Porter, John, McMillan, David, Carrington, Bruce, Turner, Alison, Scott-Tucker, Anthony, Hickford, Elizabeth S., Schmidt, Antje, Fox, David, Maloney, Alison, Ceska, Tom, Bourne, Tim, O’Connell, James, Lawson, Alastair D. G.
Publicado 2021

An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis

por Vugler, Alexander, O’Connell, James, Nguyen, Mai Anh, Weitz, Dietmar, Leeuw, Thomas, Hickford, Elizabeth, Verbitsky, Alexander, Ying, Xiaoyou, Rehberg, Markus, Carrington, Bruce, Merriman, Mark, Moss, Andrew, Nicholas, Jean-Marie, Stanley, Phil, Wright, Sara, Bourne, Tim, Foricher, Yann, Brookings, Daniel, Horsley, Helen, Herrmann, Matthias, Rao, Srinivas, Kohlmann, Markus, Florian, Peter
Publicado 2022