Costs and Causes of Oncology Drug Attrition With the Example of Insulin-Like Growth Factor-1 Receptor Inhibitors

por Jentzsch, Valerie, Osipenko, Leeza, Scannell, Jack W., Hickman, John A.
Publicado 2023

Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis

por Griffiths, Gareth J., Dubrez, Laurence, Morgan, Clive P., Jones, Neil A., Whitehouse, Jenna, Corfe, Bernard M., Dive, Caroline, Hickman, John A.
Publicado 1999

Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members

por Gallenne, Tristan, Gautier, Fabien, Oliver, Lisa, Hervouet, Eric, Noël, Belinda, Hickman, John A., Geneste, Olivier, Cartron, Pierre-François, Vallette, François M., Manon, Stephen, Juin, Philippe
Publicado 2009

N-terminally cleaved Bcl-x(L) mediates ischemia-induced neuronal death

por Ofengeim, Dimitry, Chen, Yingbei, Miyawaki, Takahiro, Li, Hongmei, Sacchetti, Silvio, Flannery, Richard J., Alavian, Kambiz N., Pontarelli, Fabrizio, Roelofs, Brian A., Hickman, John A., Hardwick, J. Marie, Zukin, R. Suzanne, Jonas, Elizabeth A.
Publicado 2012

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells

por Marty, Bérengère, Maire, Virginie, Gravier, Eléonore, Rigaill, Guillem, Vincent-Salomon, Anne, Kappler, Marion, Lebigot, Ingrid, Djelti, Fathia, Tourdès, Audrey, Gestraud, Pierre, Hupé, Philippe, Barillot, Emmanuel, Cruzalegui, Francisco, Tucker, Gordon C, Stern, Marc-Henri, Thiery, Jean-Paul, Hickman, John A, Dubois, Thierry
Publicado 2008

Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices

por Davies, Emma J., Dong, Meng, Gutekunst, Matthias, Närhi, Katja, van Zoggel, Hanneke J. A. A., Blom, Sami, Nagaraj, Ashwini, Metsalu, Tauno, Oswald, Eva, Erkens-Schulze, Sigrun, Delgado San Martin, Juan A., Turkki, Riku, Wedge, Stephen R., af Hällström, Taija M., Schueler, Julia, van Weerden, Wytske M., Verschuren, Emmy W., Barry, Simon T., van der Kuip, Heiko, Hickman, John A.
Publicado 2015

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth

por Casara, Patrick, Davidson, James, Claperon, Audrey, Le Toumelin-Braizat, Gaëtane, Vogler, Meike, Bruno, Alain, Chanrion, Maïa, Lysiak-Auvity, Gaëlle, Le Diguarher, Thierry, Starck, Jérôme-Benoît, Chen, Ijen, Whitehead, Neil, Graham, Christopher, Matassova, Natalia, Dokurno, Pawel, Pedder, Christopher, Wang, Youzhen, Qiu, Shumei, Girard, Anne-Marie, Schneider, Emilie, Gravé, Fabienne, Studeny, Aurélie, Guasconi, Ghislaine, Rocchetti, Francesca, Maïga, Sophie, Henlin, Jean-Michel, Colland, Frédéric, Kraus-Berthier, Laurence, Le Gouill, Steven, Dyer, Martin J.S., Hubbard, Roderick, Wood, Mike, Amiot, Martine, Cohen, Gerald M, Hickman, John A., Morris, Erick, Murray, James, Geneste, Olivier
Publicado 2018