An Intratumor Pharmacokinetic/Pharmacodynamic Model for the Hypoxia-Activated Prodrug Evofosfamide (TH-302): Monotherapy Activity is Not Dependent on a Bystander Effect()()

por Hong, Cho Rong, Wilson, William R., Hicks, Kevin O.
Publicado 2018

Optical coherence tomography complements confocal microscopy for investigation of multicellular tumour spheroids

por Hari, Neelam, Patel, Priyanka, Ross, Jacqueline, Hicks, Kevin, Vanholsbeeck, Frédérique
Publicado 2019

Design of Optimized Hypoxia-Activated Prodrugs Using Pharmacokinetic/Pharmacodynamic Modeling

por Foehrenbacher, Annika, Secomb, Timothy W., Wilson, William R., Hicks, Kevin O.
Publicado 2013

Bystander Effects of Hypoxia-Activated Prodrugs: Agent-Based Modeling Using Three Dimensional Cell Cultures

por Hong, Cho R., Bogle, Gib, Wang, Jingli, Patel, Kashyap, Pruijn, Frederik B., Wilson, William R., Hicks, Kevin O.
Publicado 2018

The Role of Bystander Effects in the Antitumor Activity of the Hypoxia-Activated Prodrug PR-104

por Foehrenbacher, Annika, Patel, Kashyap, Abbattista, Maria R., Guise, Chris P., Secomb, Timothy W., Wilson, William R., Hicks, Kevin O.
Publicado 2013

An agent-based model for drug-radiation interactions in the tumour microenvironment: Hypoxia-activated prodrug SN30000 in multicellular tumour spheroids

por Mao, Xinjian, McManaway, Sarah, Jaiswal, Jagdish K., Patel, Priyanka B., Wilson, William R., Hicks, Kevin O., Bogle, Gib
Publicado 2018

Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers

por Liew, Lydia P., Shome, Avik, Wong, Way W., Hong, Cho R., Hicks, Kevin O., Jamieson, Stephen M. F., Hay, Michael P.
Publicado 2023

Conversion of deoxynivalenol to 3-acetyldeoxynivalenol in barley-derived fuel ethanol co-products with yeast expressing trichothecene 3-O-acetyltransferases

por Khatibi, Piyum A, Montanti, Justin, Nghiem, Nhuan P, Hicks, Kevin B, Berger, Greg, Brooks, Wynse S, Griffey, Carl A, Schmale, David G
Publicado 2011

Tissue Pharmacokinetic Properties and Bystander Potential of Hypoxia-Activated Prodrug CP-506 by Agent-Based Modelling

por Jackson-Patel, Victoria, Liu, Emily, Bull, Matthew R., Ashoorzadeh, Amir, Bogle, Gib, Wolfram, Anna, Hicks, Kevin O., Smaill, Jeff B., Patterson, Adam V.
Publicado 2022

Protein/Arabinoxylans Gels: Effect of Mass Ratio on the Rheological, Microstructural and Diffusional Characteristics

por Berlanga-Reyes, Claudia M., Carvajal-Millan, Elizabeth, Hicks, Kevin B., Yadav, Madhav P., Rascón-Chu, Agustín, Lizardi-Mendoza, Jaime, Toledo-Guillén, Alma R., Islas-Rubio, Alma R.
Publicado 2014

Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors

por Hay, Michael P., Shin, Hong Nam, Wong, Way Wua, Sahimi, Wan Wan, Vaz, Aaron T.D., Yadav, Pooja, Anderson, Robert F., Hicks, Kevin O., Wilson, William R.
Publicado 2019

Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence

por Hicks, Kevin G, Delbecq, Scott P, Sancho-Vaello, Enea, Blanc, Marie-Pierre, Dove, Katja K, Prost, Lynne R, Daley, Margaret E, Zeth, Kornelius, Klevit, Rachel E, Miller, Samuel I
Publicado 2015

Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism

por Bezerra, Gustavo A., Foster, William R., Bailey, Henry J., Hicks, Kevin G., Sauer, Sven W., Dimitrov, Bianca, McCorvie, Thomas J., Okun, Jürgen G., Rutter, Jared, Kölker, Stefan, Yue, Wyatt W.
Publicado 2020

Sugar phosphate activation of the stress sensor eIF2B

por Hao, Qi, Heo, Jin-Mi, Nocek, Boguslaw P., Hicks, Kevin G., Stoll, Vincent S., Remarcik, Clint, Hackett, Sean, LeBon, Lauren, Jain, Rinku, Eaton, Dan, Rutter, Jared, Wong, Yao Liang, Sidrauski, Carmela
Publicado 2021

Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity

por Guise, Chris P., Abbattista, Maria R., Anderson, Robert F., Li, Dan, Taghipouran, Rana, Tsai, Angela, Lee, Su Jung, Smaill, Jeff B., Denny, William A., Hay, Michael P., Wilson, William R., Hicks, Kevin O., Patterson, Adam V.
Publicado 2020

Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice

por Gu, Yongchuan, Chang, Tony T.-A., Wang, Jingli, Jaiswal, Jagdish K., Edwards, David, Downes, Noel J., Liyanage, H. D. Sarath, Lynch, Courtney R. H., Pruijn, Frederik B., Hickey, Anthony J. R., Hay, Michael P., Wilson, William R., Hicks, Kevin O.
Publicado 2017

Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain

por Bezerra, Gustavo A., Holenstein, Alexander, Foster, William R., Xie, Bing, Hicks, Kevin G., Bürer, Céline, Lutz, Seraina, Mukherjee, Ayan, Sarkar, Dipika, Bhattacharya, Debomita, Rutter, Jared, Talukdar, Arindam, Brown, Peter J., Luo, Minkui, Shi, Lei, Froese, D. Sean, Yue, Wyatt W.
Publicado 2021

Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3

por Abbattista, Maria R., Ashoorzadeh, Amir, Guise, Christopher P., Mowday, Alexandra M., Mittra, Rituparna, Silva, Shevan, Hicks, Kevin O., Bull, Matthew R., Jackson-Patel, Victoria, Lin, Xiaojing, Prosser, Gareth A., Lambie, Neil K., Dachs, Gabi U., Ackerley, David F., Smaill, Jeff B., Patterson, Adam V.
Publicado 2021

Glyoxylate protects against cyanide toxicity through metabolic modulation

por Nielson, Jason R., Nath, Anjali K., Doane, Kim P., Shi, Xu, Lee, Jangwoen, Tippetts, Emily G., Saha, Kusumika, Morningstar, Jordan, Hicks, Kevin G., Chan, Adriano, Zhao, Yanbin, Kelly, Amy, Hendry-Hofer, Tara B., Witeof, Alyssa, Sips, Patrick Y., Mahon, Sari, Bebarta, Vikhyat S., Davisson, Vincent Jo, Boss, Gerry R., Rutter, Jared, MacRae, Calum A., Brenner, Matthew, Gerszten, Robert E., Peterson, Randall T.
Publicado 2022

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506

por van der Wiel, Alexander M.A., Jackson-Patel, Victoria, Niemans, Raymon, Yaromina, Ala, Liu, Emily, Marcus, Damiënne, Mowday, Alexandra M., Lieuwes, Natasja G., Biemans, Rianne, Lin, Xiaojing, Fu, Zhe, Kumara, Sisira, Jochems, Arthur, Ashoorzadeh, Amir, Anderson, Robert F., Hicks, Kevin O., Bull, Matthew R., Abbattista, Maria R., Guise, Christopher P., Deschoemaeker, Sofie, Thiolloy, Sophie, Heyerick, Arne, Solivio, Morwena J., Balbo, Silvia, Smaill, Jeff B., Theys, Jan, Dubois, Ludwig J., Patterson, Adam V., Lambin, Philippe
Publicado 2021