The TGF-β1/Upstream Stimulatory Factor-Regulated PAI-1 Gene: Potential Involvement and a Therapeutic Target in Alzheimer's Disease

por Higgins, Paul J.
Publicado 2006

Balancing AhR-Dependent Pro-Oxidant and Nrf2-Responsive Anti-Oxidant Pathways in Age-Related Retinopathy: Is SERPINE1 Expression a Therapeutic Target in Disease Onset and Progressi...

por Higgins, Paul J.
Publicado 2014

Editorial: Premature Aging and Senescence in Renal Fibrosis

por Samarakoon, Rohan, Higgins, Paul J.
Publicado 2021

A switch in RND3-RHOA signaling is critical for melanoma cell invasion following mutant-BRAF inhibition

por Klein, R Matthew, Higgins, Paul J
Publicado 2011

AQP2: Mutations Associated with Congenital Nephrogenic Diabetes Insipidus and Regulation by Post-Translational Modifications and Protein-Protein Interactions

por Gao, Chao, Higgins, Paul J., Zhang, Wenzheng
Publicado 2020

Downstream Targets of VHL/HIF-α Signaling in Renal Clear Cell Carcinoma Progression: Mechanisms and Therapeutic Relevance

por Mazumder, Sonia, Higgins, Paul J., Samarakoon, Rohan
Publicado 2023

Mineralocorticoid Receptor-Associated Mechanisms in Diabetic Kidney Disease and Clinical Significance of Mineralocorticoid Receptor Antagonists

por Mende, Christian W., Samarakoon, Rohan, Higgins, Paul J.
Publicado 2023

Small Molecule Targeting of PAI-1 Function: A New Therapeutic Approach for Treatment of Vascular Stenosis

por Simone, Tessa M., Archambeault, Jaclyn, Higgins, Paul J.
Publicado 2013

PAI-1 Expression Is Required for HDACi-Induced Proliferative Arrest in ras-Transformed Renal Epithelial Cells

por Higgins, Stephen P., Higgins, Craig E., Higgins, Paul J.
Publicado 2011

Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression

por Tang, Jiaqi, Gifford, Cody C., Samarakoon, Rohan, Higgins, Paul J.
Publicado 2018

TGF-β1-Induced Expression of the Poor Prognosis SERPINE1/PAI-1 Gene Requires EGFR Signaling: A New Target for Anti-EGFR Therapy

por Samarakoon, Rohan, Higgins, Craig E., Higgins, Stephen P., Higgins, Paul J.
Publicado 2009

The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1

por Samarakoon, Rohan, Higgins, Stephen P., Higgins, Craig E., Higgins, Paul J.
Publicado 2019

Editorial: The Role of Steroid Hormones and Growth Factors in Cancer

por Cernera, Gustavo, Di Donato, Marzia, Higgins, Paul J., Schlaepfer, Isabel R.
Publicado 2022

Cancer-Associated Fibroblasts: Mechanisms of Tumor Progression and Novel Therapeutic Targets

por Czekay, Ralf-Peter, Cheon, Dong-Joo, Samarakoon, Rohan, Kutz, Stacie M., Higgins, Paul J.
Publicado 2022

Chemical Antagonists of Plasminogen Activator Inhibitor-1: Mechanisms of Action and Therapeutic Potential in Vascular Disease

por Simone, Tessa M, Higgins, Stephen P, Higgins, Craig E, Lennartz, Michelle R, Higgins, Paul J
Publicado 2014

Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression

por Samarakoon, Rohan, Chitnis, Subhanir S., Higgins, Stephen P., Higgins, Craig E., Krepinsky, Joan C., Higgins, Paul J.
Publicado 2011

Complex Regulation of the Pericellular Proteolytic Microenvironment during Tumor Progression and Wound Repair: Functional Interactions between the Serine Protease and Matrix Metall...

por Wilkins-Port, Cynthia E., Higgins, Stephen P., Higgins, Craig E., Kobori-Hotchkiss, Issey, Higgins, Paul J.
Publicado 2012

PAI-1 is a Critical Upstream Regulator of the TGF-β1/EGF-Induced Invasive Phenotype in Mutant p53 Human Cutaneous Squamous Cell Carcinoma

por Wilkins-Port, Cynthia E., Higgins, Craig E., Freytag, Jennifer, Higgins, Stephen P., Carlson, J. Andrew, Higgins, Paul J.
Publicado 2007

PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma

por Freytag, Jennifer, Wilkins-Port, Cynthia E., Higgins, Craig E., Carlson, J. Andrew, Noel, Agnes, Foidart, Jean-Michel, Higgins, Stephen P., Samarakoon, Rohan, Higgins, Paul J.
Publicado 2009

CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment

por Law, Mary E., Ferreira, Renan B., Davis, Bradley J., Higgins, Paul J., Kim, Jae-Sung, Castellano, Ronald K., Chen, Sixue, Luesch, Hendrik, Law, Brian K.
Publicado 2016