Switching genes on and off during Erythropoiesis

por Higgs, Douglas R., Badat, Mohsin
Publicado 2018

α-thalassaemia

por Harteveld, Cornelis L, Higgs, Douglas R
Publicado 2010

The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization

por Oudelaar, A Marieke, Beagrie, Robert A, Kassouf, Mira T, Higgs, Douglas R
Publicado 2021

Robust detection of chromosomal interactions from small numbers of cells using low-input Capture-C

por Oudelaar, A. Marieke, Davies, James O.J., Downes, Damien J., Higgs, Douglas R., Hughes, Jim R.
Publicado 2017

Between form and function: the complexity of genome folding

por Oudelaar, A. Marieke, Hanssen, Lars L.P., Hardison, Ross C., Kassouf, Mira T., Hughes, Jim R., Higgs, Douglas R.
Publicado 2017

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus

por Oudelaar, A. Marieke, Harrold, Caroline L., Hanssen, Lars L. P., Telenius, Jelena M., Higgs, Douglas R., Hughes, Jim R.
Publicado 2019

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

por Clynes, David, Jelinska, Clare, Xella, Barbara, Ayyub, Helena, Scott, Caroline, Mitson, Matthew, Taylor, Stephen, Higgs, Douglas R., Gibbons, Richard J.
Publicado 2015

ATRX Dysfunction Induces Replication Defects in Primary Mouse Cells

por Clynes, David, Jelinska, Clare, Xella, Barbara, Ayyub, Helena, Taylor, Stephen, Mitson, Matthew, Bachrati, Csanád Z., Higgs, Douglas R., Gibbons, Richard J.
Publicado 2014

Multiplexed analysis of chromosome conformation at vastly improved sensitivity

por Davies, James O.J., Telenius, Jelena M., McGowan, Simon, Roberts, Nigel A., Taylor, Stephen, Higgs, Douglas R., Hughes, Jim R.
Publicado 2015

Loss of Atrx Affects Trophoblast Development and the Pattern of X-Inactivation in Extraembryonic Tissues

por Garrick, David, Sharpe, Jackie A, Arkell, Ruth, Dobbie, Lorraine, Smith, Andrew J. H, Wood, William G, Higgs, Douglas R, Gibbons, Richard J
Publicado 2006

Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo

por Simon, Claire S., Downes, Damien J., Gosden, Matthew E., Telenius, Jelena, Higgs, Douglas R., Hughes, Jim R., Costello, Ita, Bikoff, Elizabeth K., Robertson, Elizabeth J.
Publicado 2017

Coregulated human globin genes are frequently in spatial proximity when active

por Brown, Jill M., Leach, Joanne, Reittie, Joyce E., Atzberger, Ann, Lee-Prudhoe, Jane, Wood, William G., Higgs, Douglas R., Iborra, Francisco J., Buckle, Veronica J.
Publicado 2006

Causes and Consequences of Chromatin Variation between Inbred Mice

por Hosseini, Mona, Goodstadt, Leo, Hughes, Jim R., Kowalczyk, Monika S., de Gobbi, Marco, Otto, Georg W., Copley, Richard R., Mott, Richard, Higgs, Douglas R., Flint, Jonathan
Publicado 2013

ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes

por Voon, Hsiao P.J., Hughes, Jim R., Rode, Christina, De La Rosa-Velázquez, Inti A., Jenuwein, Thomas, Feil, Robert, Higgs, Douglas R., Gibbons, Richard J.
Publicado 2015

A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker

por Bozhilov, Yavor K., Downes, Damien J., Telenius, Jelena, Marieke Oudelaar, A., Olivier, Emmanuel N., Mountford, Joanne C., Hughes, Jim R., Gibbons, Richard J., Higgs, Douglas R.
Publicado 2021

Scalable in vitro production of defined mouse erythroblasts

por Francis, Helena S., Harold, Caroline L., Beagrie, Robert A., King, Andrew J., Gosden, Matthew E., Blayney, Joseph W., Jeziorska, Danuta M., Babbs, Christian, Higgs, Douglas R., Kassouf, Mira T.
Publicado 2022

Robust CRISPR/Cas9 Genome Editing of the HUDEP-2 Erythroid Precursor Line Using Plasmids and Single-Stranded Oligonucleotide Donors

por Moir-Meyer, Gemma, Cheong, Pak Leng, Olijnik, Aude-Anais, Brown, Jill, Knight, Samantha, King, Andrew, Kurita, Ryo, Nakamura, Yukio, Gibbons, Richard J., Higgs, Douglas R., Buckle, Veronica J., Babbs, Christian
Publicado 2018

Tissue-specific CTCF/Cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo

por Hanssen, Lars L P, Kassouf, Mira T, Oudelaar, A Marieke, Biggs, Daniel, Preece, Chris, Downes, Damien J, Gosden, Matthew, Sharpe, Jacqueline A, Sloane-Stanley, Jacqueline A, Hughes, Jim R, Davies, Benjamin, Higgs, Douglas R
Publicado 2017

Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells

por Funnell, Alister PW, Vernimmen, Douglas, Lim, Wooi F, Mak, Ka Sin, Wienert, Beeke, Martyn, Gabriella E, Artuz, Crisbel M, Burdach, Jon, Quinlan, Kate GR, Higgs, Douglas R, Whitelaw, Emma, Pearson, Richard CM, Crossley, Merlin
Publicado 2014

Association between active genes occurs at nuclear speckles and is modulated by chromatin environment

por Brown, Jill M., Green, Joanne, das Neves, Ricardo Pires, Wallace, Helen A.C., Smith, Andrew J.H., Hughes, Jim, Gray, Nicki, Taylor, Steve, Wood, William G., Higgs, Douglas R., Iborra, Francisco J., Buckle, Veronica J.
Publicado 2008