Point-of-care cell therapy manufacturing; it’s not for everyone

por Stroncek, David F., Somerville, Robert P. T., Highfill, Steven L.
Publicado 2022

Neutralization of murine myeloid-derived suppressor cells enhances the efficacy of a chimeric antigen receptor T-cells directed against pediatric solid tumors

por Highfill, Steven L, Long, Adrienne H, Orentas, Rimas J, Mackall, Crystal L
Publicado 2013

Bone marrow-derived progenitor cells develop into myeloid-derived suppressor cells at metastatic sites

por Giles, Amber, Vicioso, Yorleny, Kasai, Miki, Highfill, Steven, Mendoza, Arnulfo, Kaplan, Rosandra
Publicado 2013

Immunomagnetic B cell isolation as a tool to study blood cell subsets and enrich B cell transcripts

por Henning, Amanda N., Green, Daniel, Baumann, Ryan, Grandinetti, Patrick, Highfill, Steven L., Zhou, Huizhi, De Giorgi, Valeria
Publicado 2021

Enhanced clinical-scale manufacturing of TCR transduced T-cells using closed culture system modules

por Jin, Jianjian, Gkitsas, Nikolaos, Fellowes, Vicki S., Ren, Jiaqiang, Feldman, Steven A., Hinrichs, Christian S., Stroncek, David F., Highfill, Steven L.
Publicado 2018

Cryopreserved anti-CD22 and bispecific anti-CD19/22 CAR T cells are as effective as freshly infused cells

por Dreyzin, Alexandra, Panch, Sandhya R., Shalabi, Haneen, Yates, Bonnie, Highfill, Steven L., Jin, Ping, Stroncek, David, Shah, Nirali N.
Publicado 2022

Single cell sequencing reveals gene expression signatures associated with bone marrow stromal cell subpopulations and time in culture

por Liu, Shutong, Stroncek, David F., Zhao, Yingdong, Chen, Victoria, Shi, Rongye, Chen, Jinguo, Ren, Jiaqiang, Liu, Hui, Bae, Hee Joon, Highfill, Steven L., Jin, Ping
Publicado 2019

Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells

por Stroncek, David F., Lee, Daniel W., Ren, Jiaqiang, Sabatino, Marianna, Highfill, Steven, Khuu, Hanh, Shah, Nirali N., Kaplan, Rosandra N., Fry, Terry J., Mackall, Crystal L.
Publicado 2017

High efficiency closed-system gene transfer using automated spinoculation

por Remley, Victoria Ann, Jin, Jianjian, Sarkar, Sarmila, Moses, Larry, Prochazkova, Michaela, Cai, Yihua, Shao, Lipei, Liu, Hui, Fuksenko, Tatyana, Jin, Ping, Stroncek, David F., Highfill, Steven L.
Publicado 2021

Reference gene selection for clinical chimeric antigen receptor T-cell product vector copy number assays

por Ma, Jinxia, Shao, Lipei, Fuksenko, Tatyana, Liu, Hui, Shi, Rongye, Dinh, Anh, Highfill, Steven L., Zhang, Nan, Panch, Sandhya R., Somerville, Robert P., Stroncek, David F., Jin, Ping
Publicado 2023

Application of droplet digital PCR for the detection of vector copy number in clinical CAR/TCR T cell products

por Lu, Alex, Liu, Hui, Shi, Rongye, Cai, Yihua, Ma, Jinxia, Shao, Lipei, Rong, Victor, Gkitsas, Nikolaos, Lei, Hong, Highfill, Steven L., Panch, Sandhya, Stroncek, David F., Jin, Ping
Publicado 2020

Novel DNA-based T-Cell Activator Promotes Rapid T-Cell Activation and Expansion

por Keskar, Vandana, Sood, Anup, Loghin, Evelina, Kovacs, Ernest, Duthie, R. Scott, Liu, Shutong, Park, Jee Hyun, Chadwick, Chrystal, Smith, Reginald, Brown, Martin, Stroncek, David F., Highfill, Steven L.
Publicado 2020

Establishment and validation of in-house cryopreserved CAR/TCR-T cell flow cytometry quality control

por Cai, Yihua, Prochazkova, Michaela, Jiang, Chunjie, Song, Hannah W., Jin, Jianjian, Moses, Larry, Gkitsas, Nikolaos, Somerville, Robert P., Highfill, Steven L., Panch, Sandhya, Stroncek, David F., Jin, Ping
Publicado 2021

A Phase 1 trial of autologous monocytes stimulated ex vivo with Sylatron(®) (Peginterferon alfa-2b) and Actimmune(®) (Interferon gamma-1b) for intra-peritoneal administration in re...

por Green, Daniel S., Nunes, Ana T., David-Ocampo, Virginia, Ekwede, Irene B., Houston, Nicole D., Highfill, Steven L., Khuu, Hanh, Stroncek, David F., Steinberg, Seth M., Zoon, Kathryn C., Annunziata, Christina M.
Publicado 2018

Robust Selections of Various Hematopoietic Cell Fractions on the CliniMACS Plus Instrument

por Panch, Sandhya R., Reddy, Opal L., Li, Katherine, Bikkani, Thejaswi, Rao, Anusha, Yarlagadda, Swathi, Highfill, Steven, Fowler, Daniel, Childs, Richard W., Battiwalla, Minocher, Barrett, John, Larochelle, Andre, Mackall, Crystal, Shah, Nirali, Stroncek, David F.
Publicado 2019

Nfatc2 and Tob1 Have Non-Overlapping Function in T Cell Negative Regulation and Tumorigenesis

por May, Sarah L., Zhou, Qing, Lewellen, Mitzi, Carter, Cristan M., Coffey, David, Highfill, Steven L., Bucher, Christoph M., Matise, Ilze, Morse, Herbert C., O’Sullivan, M. Gerard, Schutten, Melissa, Johnson, Charles, Bellgrau, Donald, Blazar, Bruce R., Modiano, Jaime F.
Publicado 2014

Production of a cellular product consisting of monocytes stimulated with Sylatron(®) (Peginterferon alfa-2b) and Actimmune(®) (Interferon gamma-1b) for human use

por Green, Daniel S., Nunes, Ana T., Tosh, Kevin W., David-Ocampo, Virginia, Fellowes, Vicki S., Ren, Jiaqiang, Jin, Jianjian, Frodigh, Sue-Ellen, Pham, Chauha, Procter, Jolynn, Tran, Celina, Ekwede, Irene, Khuu, Hanh, Stroncek, David F., Highfill, Steven L., Zoon, Kathryn C., Annunziata, Christina M.
Publicado 2019

Efficacy of second CAR-T (CART2) infusion limited by poor CART expansion and antigen modulation

por Holland, Elizabeth M, Molina, John C, Dede, Kniya, Moyer, Daniel, Zhou, Ting, Yuan, Constance M, Wang, Hao-Wei, Stetler-Stevenson, Maryalice, Mackall, Crystal, Fry, Terry J, Panch, Sandhya, Highfill, Steven, Stroncek, David, Little, Lauren, Lee, Daniel W, Shalabi, Haneen, Yates, Bonnie, Shah, Nirali
Publicado 2022

Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell products

por Shao, Lipei, Shi, Rongye, Zhao, Yingdong, Liu, Hui, Lu, Alexander, Ma, Jinxia, Cai, Yihua, Fuksenko, Tatyana, Pelayo, Alejandra, Shah, Nirali N., Kochenderfer, James N., Norberg, Scott M., Hinrichs, Christian, Highfill, Steven L., Somerville, Robert P, Panch, Sandhya R., Jin, Ping, Stroncek, David F.
Publicado 2022

Preclinical development of a chimeric antigen receptor T cell therapy targeting FGFR4 in rhabdomyosarcoma

por Tian, Meijie, Wei, Jun S., Shivaprasad, Nityashree, Highfill, Steven L., Gryder, Berkley E., Milewski, David, Brown, G. Tom, Moses, Larry, Song, Hannah, Wu, Jerry T., Azorsa, Peter, Kumar, Jeetendra, Schneider, Dina, Chou, Hsien-Chao, Song, Young K., Rahmy, Abdelrahman, Masih, Katherine E., Kim, Yong Yean, Belyea, Brian, Linardic, Corinne M., Dropulic, Boro, Sullivan, Peter M., Sorensen, Poul H., Dimitrov, Dimiter S., Maris, John M., Mackall, Crystal L., Orentas, Rimas J., Cheuk, Adam T., Khan, Javed
Publicado 2023