Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway

por Garnish, Sarah E., Hildebrand, Joanne M.
Publicado 2022

Flicking the molecular switch underlying MLKL-mediated necroptosis

por Hildebrand, Joanne M, Lucet, Isabelle S, Murphy, James M
Publicado 2015

A Complex Relationship between TRAF3 and Non-Canonical NF-κB2 Activation in B Lymphocytes

por Lin, Wai W., Hildebrand, Joanne M., Bishop, Gail A.
Publicado 2013

The Role of the Key Effector of Necroptotic Cell Death, MLKL, in Mouse Models of Disease

por Tovey Crutchfield, Emma C., Garnish, Sarah E., Hildebrand, Joanne M.
Publicado 2021

A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes

por Hildebrand, Joanne M., Lo, Bernice, Tomei, Sara, Mattei, Valentina, Young, Samuel N., Fitzgibbon, Cheree, Murphy, James M., Fadda, Abeer
Publicado 2021

The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis

por Moujalled, Diane, Gangatirkar, Pradnya, Kauppi, Maria, Corbin, Jason, Lebois, Marion, Murphy, James M., Lalaoui, Najoua, Hildebrand, Joanne M., Silke, John, Alexander, Warren S., Josefsson, Emma C.
Publicado 2021

Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted

por Stutz, Michael D., Ojaimi, Samar, Allison, Cody, Preston, Simon, Arandjelovic, Philip, Hildebrand, Joanne M., Sandow, Jarrod J., Webb, Andrew I., Silke, John, Alexander, Warren S., Pellegrini, Marc
Publicado 2017

A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

por Murai, Shin, Yamaguchi, Yoshifumi, Shirasaki, Yoshitaka, Yamagishi, Mai, Shindo, Ryodai, Hildebrand, Joanne M., Miura, Ryosuke, Nakabayashi, Osamu, Totsuka, Mamoru, Tomida, Taichiro, Adachi-Akahane, Satomi, Uemura, Sotaro, Silke, John, Yagita, Hideo, Miura, Masayuki, Nakano, Hiroyasu
Publicado 2018

Addendum: A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

por Murai, Shin, Yamaguchi, Yoshifumi, Shirasaki, Yoshitaka, Yamagishi, Mai, Shindo, Ryodai, Hildebrand, Joanne M., Miura, Ryosuke, Nakabayashi, Osamu, Totsuka, Mamoru, Tomida, Taichiro, Adachi-Akahane, Satomi, Uemura, Sotaro, Silke, John, Yagita, Hideo, Miura, Masayuki, Nakano, Hiroyasu
Publicado 2019

A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling

por Hildebrand, Joanne M., Luo, Zhenghua, Manske, Michelle K., Price-Troska, Tammy, Ziesmer, Steven C., Lin, Wai, Hostager, Bruce S., Slager, Susan L., Witzig, Thomas E., Ansell, Stephen M., Cerhan, James R., Bishop, Gail A., Novak, Anne J.
Publicado 2010

The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

por Pierotti, Catia L., Jacobsen, Annette V., Grohmann, Christoph, Dempsey, Ruby K., Etemadi, Nima, Hildebrand, Joanne M., Fitzgibbon, Cheree, Young, Samuel N., Davies, Katherine A., Kersten, Wilhelmus J. A., Silke, John, Lowes, Kym N., Jousset Sabroux, Hélène, Huang, David C. S., van Delft, Mark F., Murphy, James M., Lessene, Guillaume
Publicado 2023

Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization

por Meng, Yanxiang, Garnish, Sarah E., Davies, Katherine A., Black, Katrina A., Leis, Andrew P., Horne, Christopher R., Hildebrand, Joanne M., Hoblos, Hanadi, Fitzgibbon, Cheree, Young, Samuel N., Dite, Toby, Dagley, Laura F., Venkat, Aarya, Kannan, Natarajan, Koide, Akiko, Koide, Shohei, Glukhova, Alisa, Czabotar, Peter E., Murphy, James M.
Publicado 2023

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

por Garnish, Sarah E., Meng, Yanxiang, Koide, Akiko, Sandow, Jarrod J., Denbaum, Eric, Jacobsen, Annette V., Yeung, Wayland, Samson, Andre L., Horne, Christopher R., Fitzgibbon, Cheree, Young, Samuel N., Smith, Phoebe P. C., Webb, Andrew I., Petrie, Emma J., Hildebrand, Joanne M., Kannan, Natarajan, Czabotar, Peter E., Koide, Shohei, Murphy, James M.
Publicado 2021

MLKL deficiency protects against low-grade, sterile inflammation in aged mice

por Tovey Crutchfield, Emma C., Garnish, Sarah E., Day, Jessica, Anderton, Holly, Chiou, Shene, Hempel, Anne, Hall, Cathrine, Patel, Komal M., Gangatirkar, Pradnya, Martin, Katherine R., Li Wai Suen, Connie S. N., Garnham, Alexandra L., Kueh, Andrew J., Wicks, Ian P., Silke, John, Nachbur, Ueli, Samson, Andre L., Murphy, James M., Hildebrand, Joanne M.
Publicado 2023

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

por Petrie, Emma J., Sandow, Jarrod J., Jacobsen, Annette V., Smith, Brian J., Griffin, Michael D. W., Lucet, Isabelle S., Dai, Weiwen, Young, Samuel N., Tanzer, Maria C., Wardak, Ahmad, Liang, Lung-Yu, Cowan, Angus D., Hildebrand, Joanne M., Kersten, Wilhelmus J. A., Lessene, Guillaume, Silke, John, Czabotar, Peter E., Webb, Andrew I., Murphy, James M.
Publicado 2018

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

por Samson, Andre L., Zhang, Ying, Geoghegan, Niall D., Gavin, Xavier J., Davies, Katherine A., Mlodzianoski, Michael J., Whitehead, Lachlan W., Frank, Daniel, Garnish, Sarah E., Fitzgibbon, Cheree, Hempel, Anne, Young, Samuel N., Jacobsen, Annette V., Cawthorne, Wayne, Petrie, Emma J., Faux, Maree C., Shield-Artin, Kristy, Lalaoui, Najoua, Hildebrand, Joanne M., Silke, John, Rogers, Kelly L., Lessene, Guillaume, Hawkins, Edwin D., Murphy, James M.
Publicado 2020

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

por Garnish, Sarah E., Martin, Katherine R., Kauppi, Maria, Jackson, Victoria E., Ambrose, Rebecca, Eng, Vik Ven, Chiou, Shene, Meng, Yanxiang, Frank, Daniel, Tovey Crutchfield, Emma C., Patel, Komal M., Jacobsen, Annette V., Atkin-Smith, Georgia K., Di Rago, Ladina, Doerflinger, Marcel, Horne, Christopher R., Hall, Cathrine, Young, Samuel N., Cook, Matthew, Athanasopoulos, Vicki, Vinuesa, Carola G., Lawlor, Kate E., Wicks, Ian P., Ebert, Gregor, Ng, Ashley P., Slade, Charlotte A., Pearson, Jaclyn S., Samson, André L., Silke, John, Murphy, James M., Hildebrand, Joanne M.
Publicado 2023

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

por Hildebrand, Joanne M., Kauppi, Maria, Majewski, Ian J., Liu, Zikou, Cox, Allison J., Miyake, Sanae, Petrie, Emma J., Silk, Michael A., Li, Zhixiu, Tanzer, Maria C., Brumatti, Gabriela, Young, Samuel N., Hall, Cathrine, Garnish, Sarah E., Corbin, Jason, Stutz, Michael D., Di Rago, Ladina, Gangatirkar, Pradnya, Josefsson, Emma C., Rigbye, Kristin, Anderton, Holly, Rickard, James A., Tripaydonis, Anne, Sheridan, Julie, Scerri, Thomas S., Jackson, Victoria E., Czabotar, Peter E., Zhang, Jian-Guo, Varghese, Leila, Allison, Cody C., Pellegrini, Marc, Tannahill, Gillian M., Hatchell, Esme C., Willson, Tracy A., Stockwell, Dina, de Graaf, Carolyn A., Collinge, Janelle, Hilton, Adrienne, Silke, Natasha, Spall, Sukhdeep K., Chau, Diep, Athanasopoulos, Vicki, Metcalf, Donald, Laxer, Ronald M., Bassuk, Alexander G., Darbro, Benjamin W., Fiatarone Singh, Maria A., Vlahovich, Nicole, Hughes, David, Kozlovskaia, Maria, Ascher, David B., Warnatz, Klaus, Venhoff, Nils, Thiel, Jens, Biben, Christine, Blum, Stefan, Reveille, John, Hildebrand, Michael S., Vinuesa, Carola G., McCombe, Pamela, Brown, Matthew A., Kile, Benjamin T., McLean, Catriona, Bahlo, Melanie, Masters, Seth L., Nakano, Hiroyasu, Ferguson, Polly J., Murphy, James M., Alexander, Warren S., Silke, John
Publicado 2020