Pharmacology under the microscope: the use of fluorescence correlation spectroscopy to determine the properties of ligand–receptor complexes

por Briddon, Stephen J., Hill, Stephen J.
Publicado 2007

Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates

por Baker, Jillian G., Hill, Stephen J.
Publicado 2007

The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors

por Kilpatrick, Laura E., Hill, Stephen J.
Publicado 2016

Transactivation of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs): Recent insights using luminescence and fluorescence technologies

por Kilpatrick, Laura E., Hill, Stephen J.
Publicado 2021

Characterisation of endogenous A(2A) and A(2B) receptor-mediated cyclic AMP responses in HEK 293 cells using the GloSensor™ biosensor: Evidence for an allosteric mechanism of actio...

por Goulding, Joelle, May, Lauren T., Hill, Stephen J.
Publicado 2018

Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling

por Baker, Jillian G., Hill, Stephen J., Summers, Roger J.
Publicado 2011

Impact of Polymorphic Variants on the Molecular Pharmacology of the Two-Agonist Conformations of the Human β1-Adrenoceptor

por Baker, Jillian G., Proudman, Richard G. W., Hill, Stephen J.
Publicado 2013

Effect of a toggle switch mutation in TM6 of the human adenosine A(3) receptor on Gi protein-dependent signalling and Gi-independent receptor internalization

por Stoddart, Leigh A, Kellam, Barrie, Briddon, Stephen J, Hill, Stephen J
Publicado 2014

Effects of receptor tyrosine kinase inhibitors on VEGF(165)a- and VEGF(165)b-stimulated gene transcription in HEK-293 cells expressing human VEGFR2

por Carter, Joanne J, Wheal, Amanda J, Hill, Stephen J, Woolard, Jeanette
Publicado 2015

Comparison of the ligand‐binding properties of fluorescent VEGF‐A isoforms to VEGF receptor 2 in living cells and membrane preparations using NanoBRET

por Peach, Chloe J., Kilpatrick, Laura E., Woolard, Jeanette, Hill, Stephen J.
Publicado 2019

Use of a new proximity assay (NanoBRET) to investigate the ligand‐binding characteristics of three fluorescent ligands to the human β (1)‐adrenoceptor expressed in HEK‐293 cells...

por Soave, Mark, Stoddart, Leigh A., Brown, Alastair, Woolard, Jeanette, Hill, Stephen J.
Publicado 2016

Binding kinetics of ligands acting at GPCRs

por Sykes, David A., Stoddart, Leigh A., Kilpatrick, Laura E., Hill, Stephen J.
Publicado 2019

NanoBiT Complementation to Monitor Agonist-Induced Adenosine A(1) Receptor Internalization

por Soave, Mark, Kellam, Barrie, Woolard, Jeanette, Briddon, Stephen J., Hill, Stephen J.
Publicado 2019

Involvement of β‐adrenoceptors in the cardiovascular responses induced by selective adenosine A(2A) and A(2B) receptor agonists

por Wragg, Edward S., Pannucci, Patrizia, Hill, Stephen J., Woolard, Jeanette, Cooper, Samantha L.
Publicado 2022

Biophysical Detection of Diversity and Bias in GPCR Function

por Jaeger, Werner C., Armstrong, Stephen P., Hill, Stephen J., Pfleger, Kevin D. G.
Publicado 2014

Kinetic analysis of antagonist-occupied adenosine-A(3) receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism

por Corriden, Ross, Kilpatrick, Laura E., Kellam, Barrie, Briddon, Stephen J., Hill, Stephen J.
Publicado 2014

Negative cooperativity across β(1)-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation

por Gherbi, Karolina, May, Lauren T., Baker, Jillian G., Briddon, Stephen J., Hill, Stephen J.
Publicado 2015

A nanoluciferase biosensor to investigate endogenous chemokine secretion and receptor binding

por White, Carl W., Kilpatrick, Laura E., Pfleger, Kevin D.G., Hill, Stephen J.
Publicado 2020

Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes

por Lay, Charles S., Isidro-Llobet, Albert, Kilpatrick, Laura E., Craggs, Peter D., Hill, Stephen J.
Publicado 2023

Allosteric interactions across native adenosine-A(3) receptor homodimers: quantification using single-cell ligand-binding kinetics

por May, Lauren T., Bridge, Lloyd J., Stoddart, Leigh A., Briddon, Stephen J., Hill, Stephen J.
Publicado 2011