Enabling functional genomics with genome engineering

por Hilton, Isaac B., Gersbach, Charles A.
Publicado 2015

Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector

por Kabadi, Ami M., Ousterout, David G., Hilton, Isaac B., Gersbach, Charles A.
Publicado 2014

Predicting the effect of CRISPR-Cas9-based epigenome editing

por Batra, Sanjit Singh, Cabrera, Alan, Spence, Jeffrey P., Hilton, Isaac B., Song, Yun S.
Publicado 2023

Engineering the next generation of cell-based therapeutics

por Bashor, Caleb J., Hilton, Isaac B., Bandukwala, Hozefa, Smith, Devyn M., Veiseh, Omid
Publicado 2022

Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells

por Escobar, Mario, Li, Jing, Patel, Aditi, Liu, Shizhe, Xu, Qi, Hilton, Isaac B.
Publicado 2022

Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase

por Li, Jing, Mahata, Barun, Escobar, Mario, Goell, Jacob, Wang, Kaiyuan, Khemka, Pranav, Hilton, Isaac B.
Publicado 2021

Systematic comparison of CRISPR-based transcriptional activators uncovers gene-regulatory features of enhancer–promoter interactions

por Wang, Kaiyuan, Escobar, Mario, Li, Jing, Mahata, Barun, Goell, Jacob, Shah, Spencer, Cluck, Madeleine, Hilton, Isaac B
Publicado 2022

Reversing Post-Infectious Epigenetic-Mediated Immune Suppression

por Abhimanyu, Ontiveros, Carlos O., Guerra-Resendez, Rosa S., Nishiguchi, Tomoki, Ladki, Malik, Hilton, Isaac B., Schlesinger, Larry S., DiNardo, Andrew R.
Publicado 2021

Epigenome editing by a CRISPR/Cas9-based acetyltransferase activates genes from promoters and enhancers

por Hilton, Isaac B., D’Ippolito, Anthony M., Vockley, Christopher M., Thakore, Pratiksha I., Crawford, Gregory E., Reddy, Timothy E., Gersbach, Charles A.
Publicado 2015

CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

por Klann, Tyler S., Black, Joshua B., Chellappan, Malathi, Safi, Alexias, Song, Lingyun, Hilton, Isaac B., Crawford, Gregory E., Reddy, Timothy E., Gersbach, Charles A.
Publicado 2017

Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects

por Lee, Sangsin, Ding, Ning, Sun, Yidi, Yuan, Tanglong, Li, Jing, Yuan, Qichen, Liu, Lizhong, Yang, Jie, Wang, Qian, Kolomeisky, Anatoly B., Hilton, Isaac B., Zuo, Erwei, Gao, Xue
Publicado 2020

Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control

por Mahata, Barun, Cabrera, Alan, Brenner, Daniel A., Guerra-Resendez, Rosa Selenia, Li, Jing, Goell, Jacob, Wang, Kaiyuan, Guo, Yannie, Escobar, Mario, Parthasarathy, Abinand Krishna, Szadowski, Hailey, Bedford, Guy, Reed, Daniel R., Kim, Sunghwan, Hilton, Isaac B.
Publicado 2023

Transgenic mice for in vivo epigenome editing with CRISPR-based systems

por Gemberling, Matthew P., Siklenka, Keith, Rodriguez, Erica, Tonn-Eisinger, Katherine R., Barrera, Alejandro, Liu, Fang, Kantor, Ariel, Li, Liqing, Cigliola, Valentina, Hazlett, Mariah F., Williams, Courtney A., Bartelt, Luke C., Madigan, Victoria J., Bodle, Josephine C., Daniels, Heather, Rouse, Douglas C., Hilton, Isaac B., Asokan, Aravind, Ciofani, Maria, Poss, Kenneth D., Reddy, Timothy E., West, Anne E., Gersbach, Charles A.
Publicado 2021