Biological Activity Differences between TGF-β1 and TGF-β3 Correlate with Differences in the Rigidity and Arrangement of Their Component Monomers

por Huang, Tao, Schor, Seth L., Hinck, Andrew P.
Publicado 2014

The Amino Acid Specificity for Activation of Phenylalanine Hydroxylase Matches the Specificity for Stabilization of Regulatory Domain Dimers

por Zhang, Shengnan, Hinck, Andrew P., Fitzpatrick, Paul F.
Publicado 2015

Nuclear Magnetic Resonance Structural Mapping Reveals Promiscuous Interactions between Clathrin-Box Motif Sequences and the N-Terminal Domain of the Clathrin Heavy Chain

por Zhuo, Yue, Cano, Kristin E., Wang, Liping, Ilangovan, Udayar, Hinck, Andrew P., Sousa, Rui, Lafer, Eileen M.
Publicado 2015

Distinct intramolecular interactions regulate autoinhibition of vinculin binding in αT-catenin and αE-catenin

por Heier, Jonathon A., Pokutta, Sabine, Dale, Ian W., Kim, Sun Kyung, Hinck, Andrew P., Weis, William I., Kwiatkowski, Adam V.
Publicado 2021

Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-β to its receptors, TβRI and TβRII

por Mukundan, Ananya, Byeon, Chang-Hyeock, Hinck, Cynthia S., Cunningham, Kyle, Campion, Tiffany, Smyth, Danielle J., Maizels, Rick M., Hinck, Andrew P.
Publicado 2022

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

por Ramachandran, Anassuya, Vizán, Pedro, Das, Debipriya, Chakravarty, Probir, Vogt, Janis, Rogers, Katherine W, Müller, Patrick, Hinck, Andrew P, Sapkota, Gopal P, Hill, Caroline S
Publicado 2018

An oncolytic virus–delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment

por DePeaux, Kristin, Rivadeneira, Dayana B., Lontos, Konstantinos, Dean, Victoria G., Gunn, William G., Watson, McLane J., Yao, Tianhong, Wilfahrt, Drew, Hinck, Cynthia, Wieteska, Lukasz, Thorne, Stephen H., Hinck, Andrew P., Delgoffe, Greg M.
Publicado 2023

Atomic resolution structures from fragmented protein crystals by the cryoEM method MicroED

por de la Cruz, M. Jason, Hattne, Johan, Shi, Dan, Seidler, Paul, Rodriguez, Jose, Reyes, Francis E., Sawaya, Michael R., Cascio, Duilio, Weiss, Simon C., Kim, Sun Kyung, Hinck, Cynthia S., Hinck, Andrew P., Calero, Guillermo, Eisenberg, David, Gonen, Tamir
Publicado 2017

Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling

por Villarreal, Maria M., Kim, Sun Kyung, Barron, Lindsey, Kodali, Ravi, Baardsnes, Jason, Hinck, Cynthia S., Krzysiak, Troy C., Henen, Morkos A., Pakhomova, Olga, Mendoza, Valentín, O’Connor-McCourt, Maureen D., Lafer, Eileen M., López-Casillas, Fernando, Hinck, Andrew P.
Publicado 2016

Correction to Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling

por Villarreal, Maria M., Kim, Sun Kyung, Barron, Lindsey, Kodali, Ravi, Baardsnes, Jason, Hinck, Cynthia S., Krzysiak, Troy C., Henen, Morkos A., Pakhomova, Olga, Mendoza, Valentín, O’Connor-McCourt, Maureen D., Lafer, Eileen M., López-Casillas, Fernando, Hinck, Andrew P.
Publicado 2017

A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands

por Qin, Tai, Barron, Lindsey, Xia, Lu, Huang, Haojie, Villarreal, Maria M., Zwaagstra, John, Collins, Cathy, Yang, Junhua, Zwieb, Christian, Kodali, Ravindra, Hinck, Cynthia S., Kim, Sun Kyung, Reddick, Robert L., Shu, Chang, O’Connor-McCourt, Maureen D., Hinck, Andrew P., Sun, Lu-Zhe
Publicado 2016

Correction: A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands

por Qin, Tai, Barron, Lindsey, Xia, Lu, Huang, Haojie, Villarreal, Maria M., Zwaagstra, John, Collins, Cathy, Yang, Junhua, Zwieb, Christian, Kodali, Ravindra, Hinck, Cynthia S., Kim, Sun Kyung, Reddick, Robert L., Shu, Chang, O’Connor-McCourt, Maureen D., Hinck, Andrew P., Sun, Lu-Zhe
Publicado 2017

Structural basis for potency differences between GDF8 and GDF11

por Walker, Ryan G., Czepnik, Magdalena, Goebel, Erich J., McCoy, Jason C., Vujic, Ana, Cho, Miook, Oh, Juhyun, Aykul, Senem, Walton, Kelly L., Schang, Gauthier, Bernard, Daniel J., Hinck, Andrew P., Harrison, Craig A., Martinez-Hackert, Erik, Wagers, Amy J., Lee, Richard T., Thompson, Thomas B.
Publicado 2017

CD44 acts as a coreceptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic

por van Dinther, Maarten, Cunningham, Kyle T., Singh, Shashi Prakash, White, Madeleine P. J., Campion, Tiffany, Ciancia, Claire, van Veelen, Peter A., de Ru, Arnoud H., González-Prieto, Román, Mukundan, Ananya, Byeon, Chang-Hyeock, Staggers, Sophia R., Hinck, Cynthia S., Hinck, Andrew P., Dijke, Peter ten, Maizels, Rick M.
Publicado 2023

TGFβ(+) small extracellular vesicles from head and neck squamous cell carcinoma cells reprogram macrophages towards a pro‐angiogenic phenotype

por Ludwig, Nils, Yerneni, Saigopalakrishna S., Azambuja, Juliana H., Pietrowska, Monika, Widłak, Piotr, Hinck, Cynthia S., Głuszko, Alicja, Szczepański, Mirosław J., Kärmer, Teresa, Kallinger, Isabella, Schulz, Daniela, Bauer, Richard J., Spanier, Gerrit, Spoerl, Steffen, Meier, Johannes K., Ettl, Tobias, Razzo, Beatrice M., Reichert, Torsten E., Hinck, Andrew P., Whiteside, Theresa L.
Publicado 2022

D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2

por Lin, An-Ping, Abbas, Saman, Kim, Sang-Woo, Ortega, Manoela, Bouamar, Hakim, Escobedo, Yissela, Varadarajan, Prakash, Qin, Yuejuan, Sudderth, Jessica, Schulz, Eduard, Deutsch, Alexander, Mohan, Sumitra, Ulz, Peter, Neumeister, Peter, Rakheja, Dinesh, Gao, Xiaoli, Hinck, Andrew, Weintraub, Susan T., DeBerardinis, Ralph J., Sill, Heinz, Dahia, Patricia L. M., Aguiar, Ricardo C. T.
Publicado 2015

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

por Johnston, Chris J. C., Smyth, Danielle J., Kodali, Ravindra B., White, Madeleine P. J., Harcus, Yvonne, Filbey, Kara J., Hewitson, James P., Hinck, Cynthia S., Ivens, Alasdair, Kemter, Andrea M., Kildemoes, Anna O., Le Bihan, Thierry, Soares, Dinesh C., Anderton, Stephen M., Brenn, Thomas, Wigmore, Stephen J., Woodcock, Hannah V., Chambers, Rachel C., Hinck, Andrew P., McSorley, Henry J., Maizels, Rick M.
Publicado 2017

TGFBR3L is an inhibin B co-receptor that regulates female fertility

por Brûlé, Emilie, Wang, Ying, Li, Yining, Lin, Yeu-Farn, Zhou, Xiang, Ongaro, Luisina, Alonso, Carlos A. I., Buddle, Evan R. S., Schneyer, Alan L., Byeon, Chang-Hyeock, Hinck, Cynthia S., Mendelev, Natalia, Russell, John P., Cowan, Mitra, Boehm, Ulrich, Ruf-Zamojski, Frederique, Zamojski, Michel, Andoniadou, Cynthia L., Sealfon, Stuart C., Harrison, Craig A., Walton, Kelly L., Hinck, Andrew P., Bernard, Daniel J.
Publicado 2021