5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties

por Kohn, Todd J., Du, Xiaohui, Lai, SuJen, Xiong, YuMei, Komorowski, Renee, Veniant, Murielle, Fu, Zice, Jiao, Xianyun, Pattaropong, Vatee, Chow, David, Cardozo, Mario, Jin, Lixia, Conn, Marion, DeWolf, Walter E., Kraser, Christopher F., Hinklin, Ronald J., Boys, Mark L., Medina, Julio C., Houze, Jonathan, Dransfield, Paul, Coward, Peter
Publicado 2016

SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy

por Drilon, Alexander, Sharma, Manish R., Johnson, Melissa L., Yap, Timothy A., Gadgeel, Shirish, Nepert, Dale, Feng, Gang, Reddy, Micaela B., Harney, Allison S., Elsayed, Mohamed, Cook, Adam W., Wong, Christina E., Hinklin, Ronald J., Jiang, Yutong, Brown, Eric N., Neitzel, Nickolas A., Laird, Ellen R., Wu, Wen-I, Singh, Anurag, Wei, Ping, Ching, Keith A., Gaudino, John J., Lee, Patrice A., Hartley, Dylan P., Rothenberg, S. Michael
Publicado 2023