Targeted genome fragmentation with CRISPR/Cas9 enables fast and efficient enrichment of small genomic regions and ultra-accurate sequencing with low DNA input (CRISPR-DS)

por Nachmanson, Daniela, Lian, Shenyi, Schmidt, Elizabeth K., Hipp, Michael J., Baker, Kathryn T., Zhang, Yuezheng, Tretiakova, Maria, Loubet-Senear, Kaitlyn, Kohrn, Brendan F., Salk, Jesse J., Kennedy, Scott R., Risques, Rosa Ana
Publicado 2018

A replication-linked mutational gradient drives somatic mutation accumulation and influences germline polymorphisms and genome composition in mitochondrial DNA

por Sanchez-Contreras, Monica, Sweetwyne, Mariya T, Kohrn, Brendan F, Tsantilas, Kristine A, Hipp, Michael J, Schmidt, Elizabeth K, Fredrickson, Jeanne, Whitson, Jeremy A, Campbell, Matthew D, Rabinovitch, Peter S, Marcinek, David J, Kennedy, Scott R
Publicado 2021

The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging

por Sanchez-Contreras, Monica, Sweetwyne, Mariya T, Tsantilas, Kristine A, Whitson, Jeremy A, Campbell, Matthew D, Kohrn, Brenden F, Kim, Hyeon Jeong, Hipp, Michael J, Fredrickson, Jeanne, Nguyen, Megan M, Hurley, James B, Marcinek, David J, Rabinovitch, Peter S, Kennedy, Scott R
Publicado 2023

Resistance of mitochondrial DNA to cadmium and Aflatoxin B(1) damage-induced germline mutation accumulation in C. elegans

por Leuthner, Tess C, Benzing, Laura, Kohrn, Brendan F, Bergemann, Christina M, Hipp, Michael J, Hershberger, Kathleen A, Mello, Danielle F, Sokolskyi, Tymofii, Stevenson, Kevin, Merutka, Ilaria R, Seay, Sarah A, Gregory, Simon G, Kennedy, Scott R, Meyer, Joel N
Publicado 2022

Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila

por Andreazza, Simonetta, Samstag, Colby L., Sanchez-Martinez, Alvaro, Fernandez-Vizarra, Erika, Gomez-Duran, Aurora, Lee, Juliette J., Tufi, Roberta, Hipp, Michael J., Schmidt, Elizabeth K., Nicholls, Thomas J., Gammage, Payam A., Chinnery, Patrick F., Minczuk, Michal, Pallanck, Leo J., Kennedy, Scott R., Whitworth, Alexander J.
Publicado 2019