Repurposing dyphylline as a pan-coronavirus antiviral therapy

por Wang, Yining, Rajpoot, Sajjan, Li, Pengfei, Lavrijsen, Marla, Ma, Zhongren, Hirani, Nik, Saqib, Uzma, Pan, Qiuwei, Baig, Mirza S
Publicado 2022

Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients

por Marwick, John A., Elliott, Richard J.R., Longden, James, Makda, Ashraff, Hirani, Nik, Dhaliwal, Kevin, Dawson, John C., Carragher, Neil O.
Publicado 2021

Structural analysis of spike proteins from SARS-CoV-2 variants of concern highlighting their functional alterations

por Solanki, Kundan, Rajpoot, Sajjan, Kumar, Ashutosh, J Zhang, Kam Y, Ohishi, Tomokazu, Hirani, Nik, Wadhonkar, Khandu, Patidar, Pramod, Pan, Qiuwei, Baig, Mirza S
Publicado 2022

Optical molecular imaging of lysyl oxidase activity – detection of active fibrogenesis in human lung tissue

por Aslam, Tashfeen, Miele, Amy, Chankeshwara, Sunay V., Megia-Fernandez, Alicia, Michels, Chesney, Akram, Ahsan R., McDonald, Neil, Hirani, Nik, Haslett, Chris, Bradley, Mark, Dhaliwal, Kevin
Publicado 2015

Evaluation of new or repurposed treatments for COVID-19: protocol for the phase Ib/IIa DEFINE trial platform

por Gaughan, Erin, Quinn, Tom, Bruce, Annya, Antonelli, Jean, Young, Vikki, Mair, Joanne, Akram, Ahsan, Hirani, Nik, Koch, Oliver, Mackintosh, Claire, Norrie, John, Dear, James W, Dhaliwal, Kevin
Publicado 2021

Intrapulmonary Autoantibodies to HSP72 Are Associated with Improved Outcomes in IPF

por Mills, Ross, Mathur, Abhinav, Nicol, Lisa M., Walker, Jeremy J., Przybylski, Alexander A., Mackinnon, Alison C., Howie, Sarah E. M., Wallace, William A. H., Dransfield, Ian, Hirani, Nik
Publicado 2019

Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments

por Marwick, John A., Dorward, David A., Lucas, Christopher D., Jones, Katie O., Sheldrake, Tara A., Fox, Sarah, Ward, Carol, Murray, Joanna, Brittan, Mairi, Hirani, Nik, Duffin, Rodger, Dransfield, Ian, Haslett, Christopher, Rossi, Adriano G.
Publicado 2013

Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation

por Alessandri, Ana L., Duffin, Rodger, Leitch, Andrew E., Lucas, Christopher D., Sheldrake, Tara A., Dorward, David A., Hirani, Nik, Pinho, Vanessa, de Sousa, Lirlândia Pires, Teixeira, Mauro M., Lyons, John F., Haslett, Christopher, Rossi, Adriano G.
Publicado 2011

Erratum to “Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease”

por Megia-Fernandez, Alicia, Marshall, Adam, Akram, Ahsan R., Mills, Bethany, Chankeshwara, Sunay V., Scholefield, Emma, Miele, Amy, McGorum, Bruce C., Michaels, Chesney, Knighton, Nathan, Vercauteren, Tom, Lacombe, Francois, Dentan, Veronique, Bruce, Annya M., Mair, Joanne, Hitchcock, Robert, Hirani, Nik, Haslett, Chris, Bradley, Mark, Dhaliwal, Kevin
Publicado 2023

Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease

por Megia-Fernandez, Alicia, Marshall, Adam, Akram, Ahsan R., Mills, Bethany, Chankeshwara, Sunay V., Scholefield, Emma, Miele, Amy, McGorum, Bruce C., Michaels, Chesney, Knighton, Nathan, Vercauteren, Tom, Lacombe, Francois, Dentan, Veronique, Bruce, Annya M., Mair, Joanne, Hitchcock, Robert, Hirani, Nik, Haslett, Chris, Bradley, Mark, Dhaliwal, Kevin
Publicado 2021

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair( # )

por McCowan, Jack, Fercoq, Frédéric, Kirkwood, Phoebe M., T’Jonck, Wouter, Hegarty, Lizi M., Mawer, Connar M., Cunningham, Richard, Mirchandani, Ananda S., Hoy, Anna, Humphries, Duncan C., Jones, Gareth-Rhys, Hansen, Carsten G., Hirani, Nik, Jenkins, Stephen J., Henri, Sandrine, Malissen, Bernard, Walmsley, Sarah R., Dockrell, David H., Saunders, Philippa T. K., Carlin, Leo M., Bain, Calum C.
Publicado 2021

­­­­­­­A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS­­­

por Reyes, Leila, A. Sanchez-Garcia, Manuel, Morrison, Tyler, Howden, Andy J. M., Watts, Emily R., Arienti, Simone, Sadiku, Pranvera, Coelho, Patricia, Mirchandani, Ananda S., Zhang, Ailiang, Hope, David, Clark, Sarah K., Singleton, Jo, Johnston, Shonna, Grecian, Robert, Poon, Azin, McNamara, Sarah, Harper, Isla, Fourman, Max Head, Brenes, Alejandro J., Pathak, Shalini, Lloyd, Amy, Blanco, Giovanny Rodriguez, von Kriegsheim, Alex, Ghesquiere, Bart, Vermaelen, Wesley, Cologna, Camila T., Dhaliwal, Kevin, Hirani, Nik, Dockrell, David H., Whyte, Moira K. B., Griffith, David, Cantrell, Doreen A., Walmsley, Sarah R.
Publicado 2021

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study

por Allen, Richard J, Porte, Joanne, Braybrooke, Rebecca, Flores, Carlos, Fingerlin, Tasha E, Oldham, Justin M, Guillen-Guio, Beatriz, Ma, Shwu-Fan, Okamoto, Tsukasa, John, Alison E, Obeidat, Ma'en, Yang, Ivana V, Henry, Amanda, Hubbard, Richard B, Navaratnam, Vidya, Saini, Gauri, Thompson, Norma, Booth, Helen L, Hart, Simon P, Hill, Mike R, Hirani, Nik, Maher, Toby M, McAnulty, Robin J, Millar, Ann B, Molyneaux, Philip L, Parfrey, Helen, Rassl, Doris M, Whyte, Moira K B, Fahy, William A, Marshall, Richard P, Oballa, Eunice, Bossé, Yohan, Nickle, David C, Sin, Don D, Timens, Wim, Shrine, Nick, Sayers, Ian, Hall, Ian P, Noth, Imre, Schwartz, David A, Tobin, Martin D, Wain, Louise V, Jenkins, R Gisli
Publicado 2017

Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics

por Quinn, Tom M., Gaughan, Erin E., Bruce, Annya, Antonelli, Jean, O'Connor, Richard, Li, Feng, McNamara, Sarah, Koch, Oliver, MacKintosh, Claire, Dockrell, David, Walsh, Timothy, Blyth, Kevin G., Church, Colin, Schwarze, Jürgen, Boz, Cecilia, Valanciute, Asta, Burgess, Matthew, Emanuel, Philip, Mills, Bethany, Rinaldi, Giulia, Hardisty, Gareth, Mills, Ross, Findlay, Emily Gwyer, Jabbal, Sunny, Duncan, Andrew, Plant, Sinéad, Marshall, Adam D.L., Young, Irene, Russell, Kay, Scholefield, Emma, Nimmo, Alastair F., Nazarov, Islom B., Churchill, Grant C., McCullagh, James S.O., Ebrahimi, Kourosh H., Ferrett, Colin, Templeton, Kate, Rannard, Steve, Owen, Andrew, Moore, Anne, Finlayson, Keith, Shankar-Hari, Manu, Norrie, John, Parker, Richard A., Akram, Ahsan R., Anthony, Daniel C., Dear, James W., Hirani, Nik, Dhaliwal, Kevin
Publicado 2022

PCSK6 and Survival in Idiopathic Pulmonary Fibrosis

por Oldham, Justin M., Allen, Richard J., Lorenzo-Salazar, Jose M., Molyneaux, Philip L., Ma, Shwu-Fan, Joseph, Chitra, Kim, John S., Guillen-Guio, Beatriz, Hernández-Beeftink, Tamara, Kropski, Jonathan A., Huang, Yong, Lee, Cathryn T., Adegunsoye, Ayodeji, Pugashetti, Janelle Vu, Linderholm, Angela L., Vo, Vivian, Strek, Mary E., Jou, Jonathan, Muñoz-Barrera, Adrian, Rubio-Rodriguez, Luis A., Hubbard, Richard, Hirani, Nik, Whyte, Moira K. B., Hart, Simon, Nicholson, Andrew G., Lancaster, Lisa, Parfrey, Helen, Rassl, Doris, Wallace, William, Valenzi, Eleanor, Zhang, Yingze, Mychaleckyj, Josyf, Stockwell, Amy, Kaminski, Naftali, Wolters, Paul J., Molina-Molina, Maria, Banovich, Nicholas E., Fahy, William A., Martinez, Fernando J., Hall, Ian P., Tobin, Martin D., Maher, Toby M., Blackwell, Timothy S., Yaspan, Brian L., Jenkins, R. Gisli, Flores, Carlos, Wain, Louise V., Noth, Imre
Publicado 2023

Association study of human leukocyte antigen (HLA) variants and idiopathic pulmonary fibrosis

por Guillen-Guio, Beatriz, Paynton, Megan L., Allen, Richard J., Chin, Daniel P.W., Donoghue, Lauren J., Stockwell, Amy, Leavy, Olivia C., Hernandez-Beeftink, Tamara, Reynolds, Carl, Cullinan, Paul, Martinez, Fernando, Booth, Helen L., Fahy, William A., Hall, Ian P., Hart, Simon P., Hill, Mike R., Hirani, Nik, Hubbard, Richard B., McAnulty, Robin J., Millar, Ann B., Navaratnam, Vidya, Oballa, Eunice, Parfrey, Helen, Saini, Gauri, Sayers, Ian, Tobin, Martin D., Whyte, Moira K. B., Adegunsoye, Ayodeji, Kaminski, Naftali, Shwu-Fan, Ma, Strek, Mary E., Zhang, Yingze, Fingerlin, Tasha E., Molina-Molina, Maria, Neighbors, Margaret, Sheng, X. Rebecca, Oldham, Justin M., Maher, Toby M., Molyneaux, Philip L., Flores, Carlos, Noth, Imre, Schwartz, David A., Yaspan, Brian L., Jenkins, R. Gisli, Wain, Louise V., Hollox, Edward J.
Publicado 2023

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

por Allen, Richard J., Guillen-Guio, Beatriz, Oldham, Justin M., Ma, Shwu-Fan, Dressen, Amy, Paynton, Megan L., Kraven, Luke M., Obeidat, Ma'en, Li, Xuan, Ng, Michael, Braybrooke, Rebecca, Molina-Molina, Maria, Hobbs, Brian D., Putman, Rachel K., Sakornsakolpat, Phuwanat, Booth, Helen L., Fahy, William A., Hart, Simon P., Hill, Mike R., Hirani, Nik, Hubbard, Richard B., McAnulty, Robin J., Millar, Ann B., Navaratnam, Vidyia, Oballa, Eunice, Parfrey, Helen, Saini, Gauri, Whyte, Moira K. B., Zhang, Yingze, Kaminski, Naftali, Adegunsoye, Ayodeji, Strek, Mary E., Neighbors, Margaret, Sheng, Xuting R., Gudmundsson, Gunnar, Gudnason, Vilmundur, Hatabu, Hiroto, Lederer, David J., Manichaikul, Ani, Newell, John D., O’Connor, George T., Ortega, Victor E., Xu, Hanfei, Fingerlin, Tasha E., Bossé, Yohan, Hao, Ke, Joubert, Philippe, Nickle, David C., Sin, Don D., Timens, Wim, Furniss, Dominic, Morris, Andrew P., Zondervan, Krina T., Hall, Ian P., Sayers, Ian, Tobin, Martin D., Maher, Toby M., Cho, Michael H., Hunninghake, Gary M., Schwartz, David A., Yaspan, Brian L., Molyneaux, Philip L., Flores, Carlos, Noth, Imre, Jenkins, R. Gisli, Wain, Louise V.
Publicado 2020