Molecular Biodynamers: Dynamic Covalent Analogues of Biopolymers

por Liu, Yun, Lehn, Jean-Marie, Hirsch, Anna K. H.
Publicado 2017

Protein‐Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol

por Hartman, Alwin M., Gierse, Robin M., Hirsch, Anna K. H.
Publicado 2019

The Structures and Binding Modes of Small-Molecule Inhibitors of Pseudomonas aeruginosa Elastase LasB

por Camberlein, Virgyl, Jézéquel, Gwenaëlle, Haupenthal, Jörg, Hirsch, Anna K. H.
Publicado 2022

Concepts and Core Principles of Fragment-Based Drug Design

por Kirsch, Philine, Hartman, Alwin M., Hirsch, Anna K. H., Empting, Martin
Publicado 2019

Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster

por Nesterkina, Mariia, Bilokon, Svitlana, Alieksieieva, Tetiana, Kravchenko, Iryna, Hirsch, Anna K.H.
Publicado 2023

Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin

por Hartman, Alwin M., Mondal, Milon, Radeva, Nedyalka, Klebe, Gerhard, Hirsch, Anna K. H.
Publicado 2015

1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

por Hamid, Rawia, Adam, Sebastian, Lacour, Antoine, Monjas, Leticia, Köhnke, Jesko, Hirsch, Anna K.H.
Publicado 2023

An Efficient Way to Screen Inhibitors of Energy-Coupling Factor (ECF) Transporters in a Bacterial Uptake Assay

por Bousis, Spyridon, Winkler, Steffen, Haupenthal, Jörg, Fulco, Francesco, Diamanti, Eleonora, Hirsch, Anna K. H.
Publicado 2022

Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin a Using a Staphylococcus aureus Infection Model in Zebrafish Embryos

por Fries, Franziska, Kany, Andreas M., Rasheed, Sari, Hirsch, Anna K. H., Müller, Rolf, Herrmann, Jennifer
Publicado 2023

Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment‐Based Drug Design Facilitated by Dynamic Combinatorial Chemistry

por Mondal, Milon, Radeva, Nedyalka, Fanlo‐Virgós, Hugo, Otto, Sijbren, Klebe, Gerhard, Hirsch, Anna K. H.
Publicado 2016

Saccharide‐Containing Dynamic Proteoids

por Liu, Yun, Stuart, Marc C. A., Witte, Martin D., Buhler, Eric, Hirsch, Anna K. H.
Publicado 2017

Replacement of an Indole Scaffold Targeting Human 15‐Lipoxygenase‐1 Using Combinatorial Chemistry

por Prismawan, Deka, van der Vlag, Ramon, Guo, Hao, Dekker, Frank J., Hirsch, Anna K. H.
Publicado 2019

Fragment‐Based Drug Design Facilitated by Protein‐Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin

por Mondal, Milon, Unver, M. Yagiz, Pal, Asish, Bakker, Matthijs, Berrier, Stephan P., Hirsch, Anna K. H.
Publicado 2016

Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S‐Component of the Energy‐Coupling Factor Transporter for Thiamine

por Monjas, Leticia, Swier, Lotteke J. Y. M., Setyawati, Inda, Slotboom, Dirk J., Hirsch, Anna K. H.
Publicado 2017

From Wood to Tetrahydro-2-benzazepines in Three Waste-Free Steps: Modular Synthesis of Biologically Active Lignin-Derived Scaffolds

por Elangovan, Saravanakumar, Afanasenko, Anastasiia, Haupenthal, Jörg, Sun, Zhuohua, Liu, Yongzhuang, Hirsch, Anna K. H., Barta, Katalin
Publicado 2019

Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters

por Kiefer, Alexander F., Bousis, Spyridon, Hamed, Mostafa M., Diamanti, Eleonora, Haupenthal, Jörg, Hirsch, Anna K.H.
Publicado 2022

Phage Display on the Anti‐infective Target 1‐Deoxy‐d‐xylulose‐5‐phosphate Synthase Leads to an Acceptor–Substrate Competitive Peptidic Inhibitor

por Marcozzi, Alessio, Masini, Tiziana, Zhu, Di, Pesce, Diego, Illarionov, Boris, Fischer, Markus, Herrmann, Andreas, Hirsch, Anna K. H.
Publicado 2017

Inverting Small Molecule–Protein Recognition by the Fluorine Gauche Effect: Selectivity Regulated by Multiple H→F Bioisosterism

por Bentler, Patrick, Bergander, Klaus, Daniliuc, Constantin G., Mück‐Lichtenfeld, Christian, Jumde, Ravindra P., Hirsch, Anna K. H., Gilmour, Ryan
Publicado 2019

Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar‐Based Molecules that Target Bacterial Glucosyltransferase

por Hartman, Alwin M., Jumde, Varsha R., Elgaher, Walid A. M., Te Poele, Evelien M., Dijkhuizen, Lubbert, Hirsch, Anna K. H.
Publicado 2020

Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor

por Drost, Menka, Diamanti, Eleonora, Fuhrmann, Kathrin, Goes, Adriely, Shams, Atanaz, Haupenthal, Jörg, Koch, Marcus, Hirsch, Anna K. H., Fuhrmann, Gregor
Publicado 2021