Neuronal influences are necessary to produce mitochondrial co-localization with glutamate transporters in astrocytes

por Ugbode, Christopher I, Hirst, Warren D, Rattray, Marcus
Publicado 2014

The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

por Booth, Heather D.E., Hirst, Warren D., Wade-Martins, Richard
Publicado 2017

Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson’s Disease?

por Bantle, Collin M., Hirst, Warren D., Weihofen, Andreas, Shlevkov, Evgeny
Publicado 2021

Optimization of small-scale sample preparation for high-throughput OpenArray analysis

por Abraham, Neeta A., Campbell, Anne C., Hirst, Warren D., Nezich, Catherine L.
Publicado 2021

Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection

por Ugbode, Christopher I., Smith, Imogen, Whalley, Benjamin J., Hirst, Warren D., Rattray, Marcus
Publicado 2017

Quantitative Measurements of LRRK2 in Human Cerebrospinal Fluid Demonstrates Increased Levels in G2019S Patients

por Mabrouk, Omar S., Chen, Siwei, Edwards, Amanda L., Yang, Minhua, Hirst, Warren D., Graham, Danielle L.
Publicado 2020

Evaluation of Strategies for Measuring Lysosomal Glucocerebrosidase Activity

por Ysselstein, Daniel, Young, Tiffany J., Nguyen, Maria, Padmanabhan, Shalini, Hirst, Warren D., Dzamko, Nicolas, Krainc, Dimitri
Publicado 2021

Tool Compounds Robustly Increase Turnover of an Artificial Substrate by Glucocerebrosidase in Human Brain Lysates

por Berger, Zdenek, Perkins, Sarah, Ambroise, Claude, Oborski, Christine, Calabrese, Matthew, Noell, Stephen, Riddell, David, Hirst, Warren D.
Publicado 2015

Self-report data as a tool for subtype identification in genetically-defined Parkinson’s Disease

por Winslow, Ashley R., Hyde, Craig L., Wilk, Jemma B., Eriksson, Nicholas, Cannon, Paul, Miller, Melissa R., Hirst, Warren D.
Publicado 2018

Perspective on the current state of the LRRK2 field

por Taymans, Jean-Marc, Fell, Matt, Greenamyre, Tim, Hirst, Warren D., Mamais, Adamantios, Padmanabhan, Shalini, Peter, Inga, Rideout, Hardy, Thaler, Avner
Publicado 2023

Evaluation of ABT-888 in the amelioration of α-synuclein fibril-induced neurodegeneration

por Hastings, Lyndsay, Sokratian, Arpine, Apicco, Daniel J., Stanhope, Christina M., Smith, Lindsey, Hirst, Warren D., West, Andrew B., Kelly, Kaela
Publicado 2022

A Rapid, Semi-Quantitative Assay to Screen for Modulators of Alpha-Synuclein Oligomerization Ex vivo

por Delenclos, Marion, Trendafilova, Teodora, Jones, Daryl R., Moussaud, Simon, Baine, Ann-Marie, Yue, Mei, Hirst, Warren D., McLean, Pamela J.
Publicado 2016

ASO-mediated knockdown or kinase inhibition of G2019S-Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophages

por Wallings, Rebecca L., Mark, Julian R., Staley, Hannah A., Gillett, Drew A., Neighbarger, Noelle, Kordasiewicz, Holly, Hirst, Warren D., Tansey, Malú Gámez
Publicado 2023

DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites

por Norkett, Rosalind, Modi, Souvik, Birsa, Nicol, Atkin, Talia A., Ivankovic, Davor, Pathania, Manav, Trossbach, Svenja V., Korth, Carsten, Hirst, Warren D., Kittler, Josef T.
Publicado 2016

Human A53T α-Synuclein Causes Reversible Deficits in Mitochondrial Function and Dynamics in Primary Mouse Cortical Neurons

por Li, Li, Nadanaciva, Sashi, Berger, Zdenek, Shen, Wei, Paumier, Katrina, Schwartz, Joel, Mou, Kewa, Loos, Paula, Milici, Anthony J., Dunlop, John, Hirst, Warren D.
Publicado 2013

SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures

por Nicholatos, Justin W., Groot, Joost, Dhokai, Shekhar, Tran, David, Hrdlicka, Lori, Carlile, Thomas M., Bennion, Melissa, Dalkilic-Liddle, Isin, Hirst, Warren D., Weihofen, Andreas
Publicado 2021

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

por Rideout, Hardy J., Chartier-Harlin, Marie-Christine, Fell, Matthew J., Hirst, Warren D., Huntwork-Rodriguez, Sarah, Leyns, Cheryl E. G., Mabrouk, Omar S., Taymans, Jean-Marc
Publicado 2020

Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase

por Birsa, Nicol, Norkett, Rosalind, Wauer, Tobias, Mevissen, Tycho E. T., Wu, Hsiu-Chuan, Foltynie, Thomas, Bhatia, Kailash, Hirst, Warren D., Komander, David, Plun-Favreau, Helene, Kittler, Josef T.
Publicado 2014

Identification and Characterization of a Leucine-Rich Repeat Kinase 2 (LRRK2) Consensus Phosphorylation Motif

por Pungaliya, Pooja P., Bai, Yuchen, Lipinski, Kerri, Anand, Vasanti S., Sen, Saurabh, Brown, Eugene L., Bates, Brian, Reinhart, Peter H., West, Andrew B., Hirst, Warren D., Braithwaite, Steven P.
Publicado 2010

Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy

por Van Laar, Amber D., Webb, Katherine R., Keeney, Matthew T., Van Laar, Victor S., Zharikov, Alevtina, Burton, Edward A., Hastings, Teresa G., Glajch, Kelly E., Hirst, Warren D., Greenamyre, J. Timothy, Rocha, Emily M.
Publicado 2023