Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

por Terry-Kantor, Elizabeth, Tripathi, Arati, Imberdis, Thibaut, LaVoie, Zachary M., Ho, Gary P. H., Selkoe, Dennis, Fanning, Saranna, Ramalingam, Nagendran, Dettmer, Ulf
Publicado 2020

Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase

por Imberdis, Thibaut, Negri, Joseph, Ramalingam, Nagendran, Terry-Kantor, Elizabeth, Ho, Gary P. H., Fanning, Saranna, Stirtz, Georgia, Kim, Tae-Eun, Levy, Oren A., Young-Pearse, Tracy L., Selkoe, Dennis, Dettmer, Ulf
Publicado 2019

Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy

por Fanning, Saranna, Cirka, Haley, Thies, Jennifer L., Jeong, Jooyoung, Niemi, Sarah M., Yoon, Joon, Ho, Gary P. H., Pacheco, Julian A., Dettmer, Ulf, Liu, Lei, Clish, Clary B., Hodgetts, Kevin J., Hutchinson, John N., Muratore, Christina R., Caldwell, Guy A., Caldwell, Kim A., Selkoe, Dennis
Publicado 2022

Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping

por Ndayisaba, Alain, Pitaro, Ariana T., Willett, Andrew S., Jones, Kristie A., de Gusmao, Claudio Melo, Olsen, Abby L., Kim, Jisoo, Rissanen, Eero, Woods, Jared K., Srinivasan, Sharan R., Nagy, Anna, Nagy, Amanda, Mesidor, Merlyne, Cicero, Steven, Patel, Viharkumar, Oakley, Derek H., Tuncali, Idil, Taglieri-Noble, Katherine, Clark, Emily C., Paulson, Jordan, Krolewski, Richard C., Ho, Gary P., Hung, Albert Y., Wills, Anne-Marie, Hayes, Michael T., Macmore, Jason P., Warren, Luigi, Bower, Pamela G., Langer, Carol B., Kellerman, Lawrence R., Humphreys, Christopher W., Glanz, Bonnie I., Dielubanza, Elodi J., Frosch, Matthew P., Freeman, Roy L., Gibbons, Christopher H., Stefanova, Nadia, Chitnis, Tanuja, Weiner, Howard L., Scherzer, Clemens R., Scholz, Sonja W., Vuzman, Dana, Cox, Laura M., Wenning, Gregor, Schmahmann, Jeremy D., Gupta, Anoopum S., Novak, Peter, Young, Geoffrey S., Feany, Mel B., Singhal, Tarun, Khurana, Vikram
Publicado 2022