Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

por Frock, Richard L., Hu, Jiazhi, Meyers, Robin M., Ho, Yu-Jui, Kii, Erina, Alt, Frederick W.
Publicado 2014

Single-cell RNA-seq analysis identifies markers of resistance to targeted BRAF inhibitors in melanoma cell populations

por Ho, Yu-Jui, Anaparthy, Naishitha, Molik, David, Mathew, Grinu, Aicher, Toby, Patel, Ami, Hicks, James, Hammell, Molly Gale
Publicado 2018

Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma

por Hayashi, Akimasa, Yavas, Aslihan, McIntyre, Caitlin A., Ho, Yu-jui, Erakky, Amanda, Wong, Winston, Varghese, Anna M., Melchor, Jerry P., Overholtzer, Michael, O’Reilly, Eileen M., Klimstra, David S., Basturk, Olca, Iacobuzio-Donahue, Christine A.
Publicado 2020

Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer

por Paffenholz, Stella V., Salvagno, Camilla, Ho, Yu-Jui, Limjoco, Matthew, Baslan, Timour, Tian, Sha, Kulick, Amanda, de Stanchina, Elisa, Wilkinson, John E., Barriga, Francisco M., Zamarin, Dmitriy, Cubillos-Ruiz, Juan R., Leibold, Josef, Lowe, Scott W.
Publicado 2022

Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching

por Dong, Junchao, Panchakshari, Rohit A., Zhang, Tingting, Zhang, Yu, Hu, Jiazhi, Volpi, Sabrina A., Meyers, Robin M., Ho, Yu-Jui, Du, Zhou, Robbiani, Davide F., Meng, Feilong, Gostissa, Monica, Nussenzweig, Michel C., Manis, John P., Alt, Frederick W.
Publicado 2015

Senolytic CAR T cells reverse senescence-associated pathologies

por Amor, Corina, Feucht, Judith, Leibold, Josef, Ho, Yu-Jui, Zhu, Changyu, Alonso-Curbelo, Direna, Mansilla-Soto, Jorge, Boyer, Jacob A., Li, Xiang, Giavridis, Theodoros, Kulick, Amanda, Houlihan, Shauna, Peerschke, Ellinor, Friedman, Scott L., Ponomarev, Vladimir, Piersigilli, Alessandra, Sadelain, Michel, Lowe, Scott W
Publicado 2020

Phase and context shape the function of composite oncogenic mutations

por Gorelick, Alexander N., Sánchez-Rivera, Francisco J., Cai, Yanyan, Bielski, Craig M., Biederstedt, Evan, Jonsson, Philip, Richards, Allison L., Vasan, Neil, Penson, Alexander V., Friedman, Noah D., Ho, Yu-Jui, Baslan, Timour, Bandlamudi, Chaitanya, Scaltriti, Maurizio, Schultz, Nikolaus, Lowe, Scott W., Reznik, Ed, Taylor, Barry S.
Publicado 2020

Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity

por Chen, Hsuan-An, Ho, Yu-Jui, Mezzadra, Riccardo, Adrover, Jose M., Smolkin, Ryan, Zhu, Changyu, Woess, Katharina, Bernstein, Nicholas, Schmitt, Georgia, Fong, Linda, Luan, Wei, Wuest, Alexandra, Tian, Sha, Li, Xiang, Broderick, Caroline, Hendrickson, Ronald C., Egeblad, Mikala, Chen, Zhenghao, Alonso-Curbelo, Direna, Lowe, Scott W.
Publicado 2023

MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

por Zhu, Changyu, Soto-Feliciano, Yadira M, Morris, John P, Huang, Chun-Hao, Koche, Richard P, Ho, Yu-jui, Banito, Ana, Chen, Chun-Wei, Shroff, Aditya, Tian, Sha, Livshits, Geulah, Chen, Chi-Chao, Fennell, Myles, Armstrong, Scott A, Allis, C David, Tschaharganeh, Darjus F, Lowe, Scott W
Publicado 2023

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

por Amor, Corina, Fernández-Maestre, Inés, Chowdhury, Saria, Ho, Yu-Jui, Nadella, Sandeep, Graham, Courtenay, Carrasco, Sebastian E., Nnuji-John, Emmanuella, Feucht, Judith, Hinterleitner, Clemens, Barthet, Valentin J.A., Boyer, Jacob A., Mezzadra, Riccardo, Wereski, Matthew G, Tuveson, David A., Levine, Ross L., Jones, Lee W, Sadelain, Michel, Lowe, Scott W
Publicado 2023

A gene-environment induced epigenetic program initiates tumorigenesis

por Alonso-Curbelo, Direna, Ho, Yu-Jui, Burdziak, Cassandra, Maag, Jesper L.V., Morris, John P., Chandwani, Rohit, Chen, Hsuan-An, Tsanov, Kaloyan M., Barriga, Francisco M., Luan, Wei, Tasdemir, Nilgun, Livshits, Geulah, Azizi, Elham, Chun, Jaeyoung, Wilkinson, John E., Mazutis, Linas, Leach, Steven D., Koche, Richard, Pe’er, Dana, Lowe, Scott W.
Publicado 2021

MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis

por Barriga, Francisco M., Tsanov, Kaloyan M., Ho, Yu-Jui, Sohail, Noor, Zhang, Amy, Baslan, Timour, Wuest, Alexandra N., Del Priore, Isabella, Meškauskaitė, Brigita, Livshits, Geulah, Alonso-Curbelo, Direna, Simon, Janelle, Chaves-Perez, Almudena, Bar-Sagi, Dafna, Iacobuzio-Donahue, Christine A., Notta, Faiyaz, Chaligne, Ronan, Sharma, Roshan, Pe’er, Dana, Lowe, Scott W.
Publicado 2022

A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets

por Li, Xiang, Huang, Chun-Hao, Sánchez-Rivera, Francisco J., Kennedy, Margaret C., Tschaharganeh, Darjus F., Morris, John P., Montinaro, Antonella, O'Rourke, Kevin P., Banito, Ana, Wilkinson, John E., Chen, Chi-Chao, Ho, Yu-Jui, Dow, Lukas E., Tian, Sha, Luan, Wei, de Stanchina, Elisa, Zhang, Tinghu, Gray, Nathanael S., Walczak, Henning, Lowe, Scott W.
Publicado 2022

Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants

por Sánchez-Rivera, Francisco J., Diaz, Bianca J., Kastenhuber, Edward R., Schmidt, Henri, Katti, Alyna, Kennedy, Margaret, Tem, Vincent, Ho, Yu-Jui, Leibold, Josef, Paffenholz, Stella V., Barriga, Francisco M., Chu, Kevan, Goswami, Sukanya, Wuest, Alexandra N., Simon, Janelle M., Tsanov, Kaloyan M., Chakravarty, Debyani, Zhang, Hongxin, Leslie, Christina S., Lowe, Scott W., Dow, Lukas E.
Publicado 2022

Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis

por Burdziak, Cassandra, Alonso-Curbelo, Direna, Walle, Thomas, Reyes, José, Barriga, Francisco M., Haviv, Doron, Xie, Yubin, Zhao, Zhen, Zhao, Chujun Julia, Chen, Hsuan-An, Chaudhary, Ojasvi, Masilionis, Ignas, Choo, Zi-Ning, Gao, Vianne, Luan, Wei, Wuest, Alexandra, Ho, Yu-Jui, Wei, Yuhong, Quail, Daniela F, Koche, Richard, Mazutis, Linas, Chaligné, Ronan, Nawy, Tal, Lowe, Scott W., Pe’er, Dana
Publicado 2023

Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade

por Ghosh, Arnab, Michels, Judith, Mezzadra, Riccardo, Venkatesh, Divya, Dong, Lauren, Gomez, Ricardo, Samaan, Fadi, Ho, Yu-Jui, Campesato, Luis Felipe, Mangarin, Levi, Fak, John, Suek, Nathan, Holland, Aliya, Liu, Cailian, Abu-Akeel, Mohsen, Bykov, Yonina, Zhong, Hong, Fitzgerald, Kelly, Budhu, Sadna, Chow, Andrew, Zappasodi, Roberta, Panageas, Katherine S., de Henau, Olivier, Ruscetti, Marcus, Lowe, Scott W., Merghoub, Taha, Wolchok, Jedd D.
Publicado 2022

A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin–MLL Inhibition

por Soto-Feliciano, Yadira M., Sánchez-Rivera, Francisco J., Perner, Florian, Barrows, Douglas W., Kastenhuber, Edward R., Ho, Yu-Jui, Carroll, Thomas, Xiong, Yijun, Anand, Disha, Soshnev, Alexey A., Gates, Leah, Beytagh, Mary Clare, Cheon, David, Gu, Shengqing, Liu, X. Shirley, Krivtsov, Andrei V., Meneses, Maximiliano, de Stanchina, Elisa, Stone, Richard M., Armstrong, Scott A., Lowe, Scott W., Allis, C. David
Publicado 2023

Ordered and deterministic cancer genome evolution after p53 loss

por Baslan, Timour, Morris, John P., Zhao, Zhen, Reyes, Jose, Ho, Yu-Jui, Tsanov, Kaloyan M., Bermeo, Jonathan, Tian, Sha, Zhang, Sean, Askan, Gokce, Yavas, Aslihan, Lecomte, Nicolas, Erakky, Amanda, Varghese, Anna M., Zhang, Amy, Kendall, Jude, Ghiban, Elena, Chorbadjiev, Lubomir, Wu, Jie, Dimitrova, Nevenka, Chadalavada, Kalyani, Nanjangud, Gouri J., Bandlamudi, Chaitanya, Gong, Yixiao, Donoghue, Mark T. A., Socci, Nicholas D., Krasnitz, Alex, Notta, Faiyaz, Leach, Steve D., Iacobuzio-Donahue, Christine A., Lowe, Scott W.
Publicado 2022