Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease

por Huang, Yongcheng, Cohen, Jonathan C., Hobbs, Helen H.
Publicado 2011

Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets

por Mitsche, Matthew A., Hobbs, Helen H., Cohen, Jonathan C.
Publicado 2018

Dissociation Between APOC3 Variants, Hepatic Triglyceride Content and Insulin Resistance

por Kozlitina, Julia, Boerwinkle, Eric, Cohen, Jonathan C, Hobbs, Helen H
Publicado 2011

Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

por Wang, Yan, Huang, Yongcheng, Hobbs, Helen H., Cohen, Jonathan C.
Publicado 2012

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

por BasuRay, Soumik, Smagris, Eriks, Cohen, Jonathan C., Hobbs, Helen H.
Publicado 2017

Contribution of a genetic risk score to ethnic differences in fatty liver disease

por Kubiliun, Maddie J., Cohen, Jonathan C., Hobbs, Helen H., Kozlitina, Julia
Publicado 2022

Functional characterization of genetic variants in NPC1L1 supports the sequencing extremes strategy to identify complex trait genes

por Fahmi, Saleemah, Yang, Chendong, Esmail, Sophie, Hobbs, Helen H., Cohen, Jonathan C.
Publicado 2008

Identification by whole-genome resequencing of gene defect responsible for severe hypercholesterolemia

por Rios, Jonathan, Stein, Evan, Shendure, Jay, Hobbs, Helen H., Cohen, Jonathan C.
Publicado 2010

Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice

por Banfi, Serena, Gusarova, Viktoria, Gromada, Jesper, Cohen, Jonathan C., Hobbs, Helen H.
Publicado 2018

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

por Mitsche, Matthew A, McDonald, Jeffrey G, Hobbs, Helen H, Cohen, Jonathan C
Publicado 2015

Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins

por Smagris, Eriks, Gilyard, Shenise, BasuRay, Soumik, Cohen, Jonathan C., Hobbs, Helen H.
Publicado 2016

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

por BasuRay, Soumik, Wang, Yang, Smagris, Eriks, Cohen, Jonathan C., Hobbs, Helen H.
Publicado 2019

PNPLA3, CGI‐58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice

por Wang, Yang, Kory, Nora, BasuRay, Soumik, Cohen, Jonathan C., Hobbs, Helen H.
Publicado 2019

Author Correction: Ligand-specific changes in conformational flexibility mediate long-range allostery in the lac repressor

por Glasgow, Anum, Hobbs, Helen T., Perry, Zion R., Wells, Malcolm L., Marqusee, Susan, Kortemme, Tanja
Publicado 2023

WholePathwayScope: a comprehensive pathway-based analysis tool for high-throughput data

por Yi, Ming, Horton, Jay D, Cohen, Jonathan C, Hobbs, Helen H, Stephens, Robert M
Publicado 2006

ANGPTL8 has both endocrine and autocrine effects on substrate utilization

por Oldoni, Federico, Cheng, Haili, Banfi, Serena, Gusarova, Viktoria, Cohen, Jonathan C., Hobbs, Helen H.
Publicado 2020

Ligand-specific changes in conformational flexibility mediate long-range allostery in the lac repressor

por Glasgow, Anum, Hobbs, Helen T., Perry, Zion R., Wells, Malcolm L., Marqusee, Susan, Kortemme, Tanja
Publicado 2023

Genetic Variation in ANGPTL4 Provides Insights into Protein Processing and Function

por Yin, Wu, Romeo, Stefano, Chang, Shurong, Grishin, Nick V., Hobbs, Helen H., Cohen, Jonathan C.
Publicado 2009

Differences in the dynamics of the tandem‐SH2 modules of the Syk and ZAP‐70 tyrosine kinases

por Hobbs, Helen T., Shah, Neel H., Badroos, Jean M., Gee, Christine L., Marqusee, Susan, Kuriyan, John
Publicado 2021

Saturation mutagenesis of a predicted ancestral Syk‐family kinase

por Hobbs, Helen T., Shah, Neel H., Shoemaker, Sophie R., Amacher, Jeanine F., Marqusee, Susan, Kuriyan, John
Publicado 2022