Subversion of Niche-Signalling Pathways in Colorectal Cancer: What Makes and Breaks the Intestinal Stem Cell

por Sphyris, Nathalie, Hodder, Michael C., Sansom, Owen J.
Publicado 2021

RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes

por Johansson, Joel, Naszai, Mate, Hodder, Michael C., Pickering, Karen A., Miller, Bryan W., Ridgway, Rachel A., Yu, Yachuan, Peschard, Pascal, Brachmann, Saskia, Campbell, Andrew D., Cordero, Julia B., Sansom, Owen J.
Publicado 2019

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

por Gay, David M., Ridgway, Rachel A., Müller, Miryam, Hodder, Michael C., Hedley, Ann, Clark, William, Leach, Joshua D., Jackstadt, Rene, Nixon, Colin, Huels, David J., Campbell, Andrew D., Bird, Thomas G., Sansom, Owen J.
Publicado 2019

Author Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

por Gay, David M., Ridgway, Rachel A., Müller, Miryam, Hodder, Michael C., Hedley, Ann, Clark, William, Leach, Joshua D., Jackstadt, Rene, Nixon, Colin, Huels, David J., Campbell, Andrew D., Bird, Thomas G., Sansom, Owen J.
Publicado 2019

Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas

por Heino, Sarika, Fang, Shentong, Lähde, Marianne, Högström, Jenny, Nassiri, Sina, Campbell, Andrew, Flanagan, Dustin, Raven, Alexander, Hodder, Michael, Nasreddin, Nadia, Xue, Hai-Hui, Delorenzi, Mauro, Leedham, Simon, Petrova, Tatiana V., Sansom, Owen, Alitalo, Kari
Publicado 2021

Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop

por Walter, Romina J., Sonnentag, Steffen J., Munoz-Sagredo, Leonel, Merkel, Melanie, Richert, Ludovic, Bunert, Felix, Heneka, Yvonne M., Loustau, Thomas, Hodder, Michael, Ridgway, Rachel A., Sansom, Owen J., Mely, Yves, Rothbauer, Ulrich, Schmitt, Mark, Orian-Rousseau, Véronique
Publicado 2022

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

por Myant, Kevin B, Cammareri, Patrizia, Hodder, Michael C, Wills, Jimi, Von Kriegsheim, Alex, Győrffy, Balázs, Rashid, Mamun, Polo, Simona, Maspero, Elena, Vaughan, Lynsey, Gurung, Basanta, Barry, Evan, Malliri, Angeliki, Camargo, Fernando, Adams, David J, Iavarone, Antonio, Lasorella, Anna, Sansom, Owen J
Publicado 2016

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

por Cammareri, Patrizia, Vincent, David F, Hodder, Michael C, Ridgway, Rachel A, Murgia, Claudio, Nobis, Max, Campbell, Andrew D, Varga, Julia, Huels, David J, Subramani, Chithra, Prescott, Katie L H, Nixon, Colin, Hedley, Ann, Barry, Simon T, Greten, Florian R, Inman, Gareth J, Sansom, Owen J
Publicado 2017

MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice

por Healy, Marc E., Boege, Yannick, Hodder, Michael C., Böhm, Friederike, Malehmir, Mohsen, Scherr, Anna-Lena, Jetzer, Jasna, Chan, Lap Kwan, Parrotta, Rossella, Jacobs, Kurt, Clerbaux, Laure-Alix, Kreutzer, Susanne, Campbell, Andrew, Gilchrist, Ella, Gilroy, Kathryn, Rodewald, Ann-Katrin, Honcharova-Biletska, Hanna, Schimmer, Roman, Vélez, Karelia, Büeler, Simone, Cammareri, Patrizia, Kalna, Gabriela, Wenning, Anna S., McCoy, Kathy D., Gomez de Agüero, Mercedes, Schulze-Bergkamen, Henning, Klose, Christoph S.N., Unger, Kristian, Macpherson, Andrew J., Moor, Andreas E., Köhler, Bruno, Sansom, Owen J., Heikenwälder, Mathias, Weber, Achim
Publicado 2020

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

por Leach, Joshua D. G., Vlahov, Nikola, Tsantoulis, Petros, Ridgway, Rachel A., Flanagan, Dustin J., Gilroy, Kathryn, Sphyris, Nathalie, Vázquez, Ester G., Vincent, David F., Faller, William J., Hodder, Michael C., Raven, Alexander, Fey, Sigrid, Najumudeen, Arafath K., Strathdee, Douglas, Nixon, Colin, Hughes, Mark, Clark, William, Shaw, Robin, van Hooff, Sander R., Huels, David J., Medema, Jan Paul, Barry, Simon T., Frame, Margaret C., Unciti-Broceta, Asier, Leedham, Simon J., Inman, Gareth J., Jackstadt, Rene, Thompson, Barry J., Campbell, Andrew D., Tejpar, Sabine, Sansom, Owen J.
Publicado 2021