Dynamics of the formation of a hydrogel by a pathogenic amyloid peptide: islet amyloid polypeptide

por Jean, Létitia, Lee, Chiu Fan, Hodder, Peter, Hawkins, Nick, Vaux, David J.
Publicado 2016

A FluoPol-ABPP PAD2 High-Throughput Screen Identifies the First Calcium Site Inhibitor Targeting the PADs

por Lewallen, Daniel M., Bicker, Kevin L., Madoux, Franck, Chase, Peter, Anguish, Lynne, Coonrod, Scott, Hodder, Peter, Thompson, Paul R.
Publicado 2014

Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation in Vitro

por Spicer, Timothy P., Jiang, Jianwen, Taylor, Alexander B., Choi, Jun Yong, Hart, P. John, Roush, William R., Fields, Gregg B., Hodder, Peter S., Minond, Dmitriy
Publicado 2014

Identification of Verrucarin A as a Potent and Selective Steroid Receptor Coactivator-3 Small Molecule Inhibitor

por Yan, Fei, Yu, Yang, Chow, Dar-Chone, Palzkill, Timothy, Madoux, Franck, Hodder, Peter, Chase, Peter, Griffin, Patrick R., O'Malley, Bert W., Lonard, David M.
Publicado 2014

Small Molecule Proteostasis Regulators for Protein Conformational Diseases

por Calamini, Barbara, Silva, Maria Catarina, Madoux, Franck, Hutt, Darren M., Khanna, Shilpi, Chalfant, Monica A., Saldanha, Sanjay A., Hodder, Peter, Tait, Bradley D., Garza, Dan, Balch, William E., Morimoto, Richard I.
Publicado 2011

Identification of Small Molecules that Disrupt Signaling between ABL and Its Positive Regulator RIN1

por Ting, Pamela Y., Damoiseaux, Robert, Titz, Björn, Bradley, Kenneth A., Graeber, Thomas G., Fernández-Vega, Virneliz, Bannister, Thomas D., Chase, Peter, Nair, Reji, Scampavia, Louis, Hodder, Peter, Spicer, Timothy P., Colicelli, John
Publicado 2015

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of...

por Turlington, Mark, Chun, Aspen, Tomar, Sakshi, Eggler, Aimee, Grum-Tokars, Valerie, Jacobs, Jon, Daniels, J. Scott, Dawson, Eric, Saldanha, Adrian, Chase, Peter, Baez-Santos, Yahira M., Lindsley, Craig W., Hodder, Peter, Mesecar, Andrew D., Stauffer, Shaun R.
Publicado 2013

Development of a Highly Potent, Novel M(5) Positive Allosteric Modulator (PAM) Demonstrating CNS Exposure: 1-((1H-Indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piper...

por Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Noetzel, Meredith J., Cho, Hyekyung P., Lamsal, Atin, Smith, Emery, Chase, Peter, Hodder, Peter S., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
Publicado 2014

Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment

por Wang, Leiming, Cheng, Chiang-Min, Qin, Jun, Xu, Mafei, Kao, Chung-Yang, Shi, Jingjing, You, Erli, Gong, Wanchun, Rosa, Laura Pedro, Chase, Peter, Scampavia, Louis, Madoux, Franck, Spicer, Timothy, Hodder, Peter, Xu, H. Eric, Tsai, Sophia Y., Tsai, Ming-Jer
Publicado 2020

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

por Plate, Lars, Cooley, Christina B, Chen, John J, Paxman, Ryan J, Gallagher, Ciara M, Madoux, Franck, Genereux, Joseph C, Dobbs, Wesley, Garza, Dan, Spicer, Timothy P, Scampavia, Louis, Brown, Steven J, Rosen, Hugh, Powers, Evan T, Walter, Peter, Hodder, Peter, Wiseman, R Luke, Kelly, Jeffery W
Publicado 2016

Target-Based Screen Against a Periplasmic Serine Protease That Regulates Intrabacterial pH Homeostasis in Mycobacterium tuberculosis

por Zhao, Nan, Darby, Crystal M., Small, Jennifer, Bachovchin, Daniel A., Jiang, Xiuju, Burns-Huang, Kristin E., Botella, Helene, Ehrt, Sabine, Boger, Dale L., Anderson, Erin D., Cravatt, Benjamin F., Speers, Anna E., Fernandez-Vega, Virneliz, Hodder, Peter S., Eberhart, Christina, Rosen, Hugh, Spicer, Timothy P., Nathan, Carl F.
Publicado 2014