Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists

por Ajram, Laura, Begg, Malcolm, Slack, Robert, Cryan, Jenni, Hall, David, Hodgson, Simon, Ford, Alison, Barnes, Ashley, Swieboda, Dawid, Mousnier, Aurelie, Solari, Roberto
Publicado 2014

Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a ran...

por Cahn, Anthony, Hodgson, Simon, Wilson, Robert, Robertson, Jonathan, Watson, Joanna, Beerahee, Misba, Hughes, Steve C, Young, Graeme, Graves, Rebecca, Hall, David, van Marle, Sjoerd, Solari, Roberto
Publicado 2013

Antagonism of human CC-chemokine receptor 4 can be achieved through three distinct binding sites on the receptor

por Slack, Robert J, Russell, Linda J, Barton, Nick P, Weston, Cathryn, Nalesso, Giovanna, Thompson, Sally-Anne, Allen, Morven, Chen, Yu Hua, Barnes, Ashley, Hodgson, Simon T, Hall, David A
Publicado 2013

Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedem...

por Davie, Rebecca L., Edwards, Hannah J., Evans, D. Michael, Hodgson, Simon T., Stocks, Michael J., Smith, Alun J., Rushbrooke, Louise J., Pethen, Stephen J., Roe, Michael B., Clark, David E., McEwan, Paul A., Hampton, Sally L.
Publicado 2022

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

por Heifetz, Alexander, Schertler, Gebhard F. X., Seifert, Roland, Tate, Christopher G., Sexton, Patrick M., Gurevich, Vsevolod V., Fourmy, Daniel, Cherezov, Vadim, Marshall, Fiona H., Storer, R. Ian, Moraes, Isabel, Tikhonova, Irina G., Tautermann, Christofer S., Hunt, Peter, Ceska, Tom, Hodgson, Simon, Bodkin, Mike J., Singh, Shweta, Law, Richard J., Biggin, Philip C.
Publicado 2015