Gene Therapy Research at the Frontiers of Viral Immunology

por Hoffman, Brad E., Ertl, Hildegund C. J., Terhorst, Cox, High, Katherine A., Herzog, Roland W.
Publicado 2012

Potential for cellular stress response to hepatic factor VIII expression from AAV vector

por Zolotukhin, Irene, Markusic, David M, Palaschak, Brett, Hoffman, Brad E, Srikanthan, Meera A, Herzog, Roland W
Publicado 2016

AAV3-miRNA vectors for growth suppression of human hepatocellular carcinoma cells in vitro and human liver tumors in a murine xenograft model in vivo

por Yin, Ling, Keeler, Geoffrey D., Zhang, Yuanhui, Hoffman, Brad E., Ling, Chen, Qing, Keyun, Srivastava, Arun
Publicado 2020

Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis

por Keeler, Geoffrey D., Kumar, Sandeep, Palaschak, Brett, Silverberg, Emily L., Markusic, David M., Jones, Noah T., Hoffman, Brad E.
Publicado 2018

Prevention and Reversal of Antibody Responses Against Factor IX in Gene Therapy for Hemophilia B

por Nayak, Sushrusha, Sarkar, Debalina, Perrin, George Q., Moghimi, Babak, Hoffman, Brad E., Zhou, Shangzhen, Byrne, Barry J., Herzog, Roland W.
Publicado 2011

Tolerance Induction to Cytoplasmic β-Galactosidase by Hepatic AAV Gene Transfer — Implications for Antigen Presentation and Immunotoxicity

por Martino, Ashley T., Nayak, Sushrusha, Hoffman, Brad E., Cooper, Mario, Liao, Gongxian, Markusic, David M., Byrne, Barry J., Terhorst, Cox, Herzog, Roland W.
Publicado 2009

Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies

por Markusic, David M, Hoffman, Brad E, Perrin, George Q, Nayak, Sushrusha, Wang, Xiaomei, LoDuca, Paul A, High, Katherine A, Herzog, Roland W
Publicado 2013

Induction of antigen-specific tolerance by hepatic AAV immunotherapy regardless of T cell epitope usage or mouse strain background

por Keeler, Geoffrey D., Gaddie, Cristina D., Sagadevan, Addelynn S., Senior, Kevin G., Côté, Isabelle, Rechdan, Michaela, Min, Daniel, Mahan, David, Poma, Bianca, Hoffman, Brad E.
Publicado 2022

Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia

por Sarkar, Debalina, Biswas, Moanaro, Liao, Gongxian, Seay, Howard R, Perrin, George Q, Markusic, David M, Hoffman, Brad E, Brusko, Todd M, Terhorst, Cox, Herzog, Roland W
Publicado 2014

Enhanced Transduction of Human Hematopoietic Stem Cells by AAV6 Vectors: Implications in Gene Therapy and Genome Editing

por Yang, Hua, Qing, Keyun, Keeler, Geoffrey D., Yin, Ling, Mietzsch, Mario, Ling, Chen, Hoffman, Brad E., Agbandje-McKenna, Mavis, Tan, Mengqun, Wang, Wei, Srivastava, Arun
Publicado 2020