A method to investigate the anti-metabolic activity of anti-cancer agents on ovarian cancer cells cultured in a 96-well high throughput format

por Hogg, Simon J., Evans, John J., Sykes, Peter H., Chitcholtan, Kenny
Publicado 2015

Resveratrol, Acetyl-Resveratrol, and Polydatin Exhibit Antigrowth Activity against 3D Cell Aggregates of the SKOV-3 and OVCAR-8 Ovarian Cancer Cell Lines

por Hogg, Simon J., Chitcholtan, Kenny, Hassan, Wafaa, Sykes, Peter H., Garrill, Ashley
Publicado 2015

Whole genome CRISPR screening identifies TOP2B as a potential target for IMiD sensitization in multiple myeloma

por Costacurta, Matteo, Vervoort, Stephin J, Hogg, Simon J, Martin, Benjamin P, Johnstone, Ricky W, Shortt, Jake
Publicado 2020

The natural function of the malaria parasite’s chloroquine resistance transporter

por Shafik, Sarah H., Cobbold, Simon A., Barkat, Kawthar, Richards, Sashika N., Lancaster, Nicole S., Llinás, Manuel, Hogg, Simon J., Summers, Robert L., McConville, Malcolm J., Martin, Rowena E.
Publicado 2020

Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer

por Hogg, Simon J., Motorna, Olga, Kearney, Conor J., Derrick, Emily B., House, Imran G., Todorovski, Izabela, Kelly, Madison J., Zethoven, Magnus, Bromberg, Kenneth D., Lai, Albert, Beavis, Paul A., Shortt, Jake, Johnstone, Ricky W., Vervoort, Stephin J.
Publicado 2022

E7820, an anti-cancer sulfonamide, degrades RBM39 in patients with splicing factor mutant myeloid malignancies: a phase II clinical trial

por Bewersdorf, Jan Philipp, Stahl, Maximilian, Taylor, Justin, Mi, Xiaoli, Chandhok, Namrata Sonia, Watts, Justin, Derkach, Andriy, Wysocki, Mateusz, Lu, Sydney X., Bourcier, Jessie, Hogg, Simon J., Rahman, Jahan, Chaudhry, Sana, Totiger, Tulasigeri M., Abdel-Wahab, Omar, Stein, Eytan M.
Publicado 2023

P1212: RATIONALLY DESIGNED CHIMERIC PI3K-BET BROMODOMAIN INHIBITORS ELICIT CURATIVE RESPONSES IN MYC-DRIVEN LYMPHOMA

por Oh, Danielle H., MA, Xiao, He, Jackson, Kearney, Conor, Hogg, Simon J., Newbold, Andrea, Fraser, Peter, Jennings, Ian G., Brasacchio, Daniella, Susanto, Olivia, Yew Fong, Chun, Dawson, Mark A., Gruber, Emily, Kats, Lev, Johnstone, Ricky W., Thompson, Philip E., Shortt, Jake
Publicado 2023

Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia

por So, Joan, Lewis, Alexander C, Smith, Lorey K, Stanley, Kym, Franich, Rheana, Yoannidis, David, Pijpers, Lizzy, Dominguez, Pilar, Hogg, Simon J, Vervoort, Stephin J, Brown, Fiona C, Johnstone, Ricky W, McDonald, Gabrielle, Ulanet, Danielle B, Murtie, Josh, Gruber, Emily, Kats, Lev M
Publicado 2022

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

por Hogg, Simon J., Vervoort, Stephin J., Deswal, Sumit, Ott, Christopher J., Li, Jason, Cluse, Leonie A., Beavis, Paul A., Darcy, Phillip K., Martin, Benjamin P., Spencer, Andrew, Traunbauer, Anna K., Sadovnik, Irina, Bauer, Karin, Valent, Peter, Bradner, James E., Zuber, Johannes, Shortt, Jake, Johnstone, Ricky W.
Publicado 2017

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

por Fan, Zheng, Devlin, Jennifer R., Hogg, Simon J., Doyle, Maria A., Harrison, Paul F., Todorovski, Izabela, Cluse, Leonie A., Knight, Deborah A., Sandow, Jarrod J., Gregory, Gareth, Fox, Andrew, Beilharz, Traude H., Kwiatkowski, Nicholas, Scott, Nichollas E., Vidakovic, Ana Tufegdzic, Kelly, Gavin P., Svejstrup, Jesper Q., Geyer, Matthias, Gray, Nathanael S., Vervoort, Stephin J., Johnstone, Ricky W.
Publicado 2020

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

por Fujihara, Kenji M., Zhang, Bonnie Z., Jackson, Thomas D., Ogunkola, Moses O., Nijagal, Brunda, Milne, Julia V., Sallman, David A., Ang, Ching-Seng, Nikolic, Iva, Kearney, Conor J., Hogg, Simon J., Cabalag, Carlos S., Sutton, Vivien R., Watt, Sally, Fujihara, Asuka T., Trapani, Joseph A., Simpson, Kaylene J., Stojanovski, Diana, Leimkühler, Silke, Haupt, Sue, Phillips, Wayne A., Clemons, Nicholas J.
Publicado 2022

Integrated clinical and genomic evaluation of guadecitabine (SGI-110) in peripheral T-cell lymphoma

por Wong, Jonathan, Gruber, Emily, Maher, Belinda, Waltham, Mark, Sabouri-Thompson, Zahra, Jong, Ian, Luong, Quinton, Levy, Sidney, Kumar, Beena, Brasacchio, Daniella, Jia, Wendy, So, Joan, Skinner, Hugh, Lewis, Alexander, Hogg, Simon J., Vervoort, Stephin, DiCorleto, Carmen, Uhe, Micheleine, Gamgee, Jeanette, Opat, Stephen, Gregory, Gareth P., Polekhina, Galina, Reynolds, John, Hawkes, Eliza A., Kailainathan, Gajan, Gasiorowski, Robin, Kats, Lev M., Shortt, Jake
Publicado 2022

Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

por Chen, Sisi, Vedula, Rahul S., Cuevas-Navarro, Antonio, Lu, Bin, Hogg, Simon J., Wang, Eric, Benbarche, Salima, Knorr, Katherine, Kim, Won Jun, Stanley, Robert F., Cho, Hana, Erickson, Caroline, Singer, Michael, Cui, Dan, Tittley, Steven, Durham, Benjamin H., Pavletich, Tatiana S., Fiala, Elise, Walsh, Michael F., Inoue, Daichi, Monette, Sebastien, Taylor, Justin, Rosen, Neal, McCormick, Frank, Lindsley, R. Coleman, Castel, Pau, Abdel-Wahab, Omar
Publicado 2022

Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition

por Inoue, Daichi, Polaski, Jacob T., Taylor, Justin, Castel, Pau, Chen, Sisi, Kobayashi, Susumu, Hogg, Simon J., Hayashi, Yasutaka, Pineda, Jose Mario Bello, El Marabti, Ettaib, Erickson, Caroline, Knorr, Katherine, Fukumoto, Miki, Yamazaki, Hiromi, Tanaka, Atsushi, Fukui, Chie, Lu, Sydney X., Durham, Benjamin H., Liu, Bo, Wang, Eric, Mehta, Sanjoy, Zakheim, Daniel, Garippa, Ralph, Penson, Alex, Chew, Guo-Liang, McCormick, Frank, Bradley, Robert K., Abdel-Wahab, Omar
Publicado 2021

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia

por Tanaka, Atsushi, Nakano, Taizo A., Nomura, Masaki, Yamazaki, Hiromi, Bewersdorf, Jan P., Mulet-Lazaro, Roger, Hogg, Simon, Liu, Bo, Penson, Alex, Yokoyama, Akihiko, Zang, Weijia, Havermans, Marije, Koizumi, Miho, Hayashi, Yasutaka, Cho, Hana, Kanai, Akinori, Lee, Stanley C., Xiao, Muran, Koike, Yui, Zhang, Yifan, Fukumoto, Miki, Aoyama, Yumi, Konuma, Tsuyoshi, Kunimoto, Hiroyoshi, Inaba, Toshiya, Nakajima, Hideaki, Honda, Hiroaki, Kawamoto, Hiroshi, Delwel, Ruud, Abdel-Wahab, Omar, Inoue, Daichi
Publicado 2022

Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

por Salmon, Jessica M., Todorovski, Izabela, Stanley, Kym L., Bruedigam, Claudia, Kearney, Conor J., Martelotto, Luciano G., Rossello, Fernando, Semple, Timothy, Arnau, Gisela Mir, Zethoven, Magnus, Bots, Michael, Bjelosevic, Stefan, Cluse, Leonie A., Fraser, Peter J., Litalien, Veronique, Vidacs, Eva, McArthur, Kate, Matthews, Antony Y., Gressier, Elise, de Weerd, Nicole A., Lichte, Jens, Kelly, Madison J., Hogg, Simon J., Hertzog, Paul J., Kats, Lev M., Vervoort, Stephin J., De Carvalho, Daniel D., Scheu, Stefanie, Bedoui, Sammy, Kile, Benjamin T., Lane, Steven W., Perkins, Andrew C., Wei, Andrew H., Dominguez, Pilar M., Johnstone, Ricky W.
Publicado 2022