Precursor Structure of Cephalosporin Acylase: Insights into Auto-Proteolytic Activation in a New N-Terminal Hydrolase Family

por Kim, Youngsoo, Kim, Sanggu, Earnest, Thomas N., Hol, Wim G.J.
Publicado 2002

Structure of the cholera toxin secretion channel in its closed state

por Reichow, Steve L., Korotkov, Konstantin V., Hol, Wim G. J., Gonen, Tamir
Publicado 2010

Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody

por Park, Young-Jun, Pardon, Els, Wu, Meiting, Steyaert, Jan, Hol, Wim G. J.
Publicado 2012

The Role of Medical Structural Genomics in Discovering New Drugs for Infectious Diseases

por Van Voorhis, Wesley C., Hol, Wim G. J., Myler, Peter J., Stewart, Lance J.
Publicado 2009

Zinc coordination is essential for the function and activity of the type II secretion ATPase EpsE

por Rule, Chelsea S., Patrick, Marcella, Camberg, Jodi L., Maricic, Natalie, Hol, Wim G., Sandkvist, Maria
Publicado 2016

The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2

por Park, Young-Jun, Budiarto, Tanya, Wu, Meiting, Pardon, Els, Steyaert, Jan, Hol, Wim G. J.
Publicado 2012

Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease

por Rule, Chelsea S., Park, Young-Jun, Delarosa, Jaclyn R., Turley, Stewart, Hol, Wim G. J., McColm, Sarah, Gura, Colby, DiMaio, Frank, Korotkov, Konstantin V., Sandkvist, Maria
Publicado 2020

Structural and Functional Studies on the Interaction of GspC and GspD in the Type II Secretion System

por Korotkov, Konstantin V., Johnson, Tanya L., Jobling, Michael G., Pruneda, Jonathan, Pardon, Els, Héroux, Annie, Turley, Stewart, Steyaert, Jan, Holmes, Randall K., Sandkvist, Maria, Hol, Wim G. J.
Publicado 2011

5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors

por Zhang, Zhongsheng, Koh, Cho Yeow, Ranade, Ranae M., Shibata, Sayaka, Gillespie, J. Robert, Hulverson, Matthew A., Huang, Wenlin, Nguyen, Jasmine, Pendem, Nagendar, Gelb, Michael H., Verlinde, Christophe L. M. J., Hol, Wim G. J., Buckner, Frederick S., Fan, Erkang
Publicado 2016

Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness

por Koh, Cho Yeow, Kim, Jessica E., Wetzel, Allan B., de van der Schueren, Will J., Shibata, Sayaka, Ranade, Ranae M., Liu, Jiyun, Zhang, Zhongsheng, Gillespie, J. Robert, Buckner, Frederick S., Verlinde, Christophe L. M. J., Fan, Erkang, Hol, Wim G. J.
Publicado 2014

Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy

por Ojo, Kayode K., Reid, Molly C., Kallur Siddaramaiah, Latha, Müller, Joachim, Winzer, Pablo, Zhang, Zhongsheng, Keyloun, Katelyn R., Vidadala, Rama Subba Rao, Merritt, Ethan A., Hol, Wim G. J., Maly, Dustin J., Fan, Erkang, Van Voorhis, Wesley C., Hemphill, Andrew
Publicado 2014

Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry

por Vu, Hoan, Pedro, Liliana, Mak, Tin, McCormick, Brendan, Rowley, Jessica, Liu, Miaomiao, Di Capua, Angela, Williams-Noonan, Billy, Pham, Ngoc B., Pouwer, Rebecca, Nguyen, Bao, Andrews, Katherine T., Skinner-Adams, Tina, Kim, Jessica, Hol, Wim G. J., Hui, Raymond, Crowther, Gregory J., Van Voorhis, Wesley C., Quinn, Ronald J.
Publicado 2018

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

por Huang, Wenlin, Ojo, Kayode K., Zhang, Zhongsheng, Rivas, Kasey, Vidadala, Rama Subba Rao, Scheele, Suzanne, DeRocher, Amy E., Choi, Ryan, Hulverson, Matthew A., Barrett, Lynn K., Bruzual, Igor, Siddaramaiah, Latha Kallur, Kerchner, Keshia M., Kurnick, Matthew D., Freiberg, Gail M., Kempf, Dale, Hol, Wim G. J., Merritt, Ethan A., Neckermann, Georg, de Hostos, Eugenio L., Isoherranen, Nina, Maly, Dustin J., Parsons, Marilyn, Doggett, J. Stone, Van Voorhis, Wesley C., Fan, Erkang
Publicado 2015