Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis

por Zyla, Edyta, Musielak, Bogdan, Holak, Tad A., Dubin, Grzegorz
Publicado 2021

Helping the Released Guardian: Drug Combinations for Supporting the Anticancer Activity of HDM2 (MDM2) Antagonists

por Kocik, Justyna, Machula, Monika, Wisniewska, Aneta, Surmiak, Ewa, Holak, Tad A., Skalniak, Lukasz
Publicado 2019

The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells

por Ammon, Tim, Mishra, Shravan Kumar, Kowalska, Kaja, Popowicz, Grzegorz M., Holak, Tad A., Jentsch, Stefan
Publicado 2014

Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity

por Chudzian, Julia, Szlachcic, Anna, Zakrzewska, Malgorzata, Czub, Miroslawa, Pustula, Marcin, Holak, Tad A., Otlewski, Jacek
Publicado 2018

Artificial Macrocycles as Potent p53–MDM2 Inhibitors

por Estrada-Ortiz, Natalia, Neochoritis, Constantinos G., Twarda-Clapa, Aleksandra, Musielak, Bogdan, Holak, Tad A., Dömling, Alexander
Publicado 2017

Prolonged Idasanutlin (RG7388) Treatment Leads to the Generation of p53-Mutated Cells

por Skalniak, Lukasz, Kocik, Justyna, Polak, Justyna, Skalniak, Anna, Rak, Monika, Wolnicka-Glubisz, Agnieszka, Holak, Tad A.
Publicado 2018

Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)

por Zak, Krzysztof M., Grudnik, Przemyslaw, Guzik, Katarzyna, Zieba, Bartosz J., Musielak, Bogdan, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.
Publicado 2016

Computer- and NMR-Aided Design of Small-Molecule Inhibitors of the Hub1 Protein

por Reyes Romero, Atilio, Kubica, Katarzyna, Kitel, Radoslaw, Rodríguez, Ismael, Magiera-Mularz, Katarzyna, Dömling, Alexander, Holak, Tad A., Surmiak, Ewa
Publicado 2022

Development of the Inhibitors That Target the PD-1/PD-L1 Interaction—A Brief Look at Progress on Small Molecules, Peptides and Macrocycles

por Guzik, Katarzyna, Tomala, Marcin, Muszak, Damian, Konieczny, Magdalena, Hec, Aleksandra, Błaszkiewicz, Urszula, Pustuła, Marcin, Butera, Roberto, Dömling, Alexander, Holak, Tad A.
Publicado 2019

PD-L1 Inhibitors: Different Classes, Activities, and Mechanisms of Action

por Surmiak, Ewa, Magiera-Mularz, Katarzyna, Musielak, Bogdan, Muszak, Damian, Kocik-Krol, Justyna, Kitel, Radoslaw, Plewka, Jacek, Holak, Tad A., Skalniak, Lukasz
Publicado 2021

IGF2 Peptide-Based LYTACs for Targeted Degradation of Extracellular and Transmembrane Proteins

por Mikitiuk, Michał, Barczyński, Jan, Bielski, Przemysław, Arciniega, Marcelino, Tyrcha, Urszula, Hec, Aleksandra, Lipińska, Andrea D., Rychłowski, Michał, Holak, Tad A., Sitar, Tomasz
Publicado 2023

Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists

por Neochoritis, Constantinos G, Kazemi Miraki, Maryam, Abdelraheem, Eman M M, Surmiak, Ewa, Zarganes-Tzitzikas, Tryfon, Łabuzek, Beata, Holak, Tad A, Dömling, Alexander
Publicado 2019

CA-170 – A Potent Small-Molecule PD-L1 Inhibitor or Not?

por Musielak, Bogdan, Kocik, Justyna, Skalniak, Lukasz, Magiera-Mularz, Katarzyna, Sala, Dominik, Czub, Miroslawa, Stec, Malgorzata, Siedlar, Maciej, Holak, Tad A., Plewka, Jacek
Publicado 2019

Analysis tools for single-monomer measurements of self-assembly processes

por Hoyer, Maria, Crevenna, Alvaro H., Kitel, Radoslaw, Willems, Kherim, Czub, Miroslawa, Dubin, Grzegorz, Van Dorpe, Pol, Holak, Tad A., Lamb, Don C.
Publicado 2022

Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists

por Koes, David, Khoury, Kareem, Huang, Yijun, Wang, Wei, Bista, Michal, Popowicz, Grzegorz M., Wolf, Siglinde, Holak, Tad A., Dömling, Alexander, Camacho, Carlos J.
Publicado 2012

Fragment-Based Library Generation for the Discovery of a Peptidomimetic p53-Mdm4 Inhibitor

por Boltjes, André, Huang, Yijun, van de Velde, Rob, Rijkee, Laurie, Wolf, Siglinde, Gaugler, James, Lesniak, Katarzyna, Guzik, Katarzyna, Holak, Tad A., Dömling, Alexander
Publicado 2014

Discovery of Highly Potent p53-MDM2 Antagonists and Structural Basis for Anti-Acute Myeloid Leukemia Activities

por Huang, Yijun, Wolf, Siglinde, Beck, Barbara, Köhler, Lisa-Maria, Khoury, Kareem, Popowicz, Grzegorz M., Goda, Sayed K, Subklewe, Marion, Twarda, Aleksandra, Holak, Tad A., Dömling, Alexander
Publicado 2014

Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G(0)/G(1) Arrest by Inhibiting Deubiquitinase USP2a

por Magiera, Katarzyna, Tomala, Marcin, Kubica, Katarzyna, De Cesare, Virginia, Trost, Matthias, Zieba, Bartosz J., Kachamakova-Trojanowska, Neli, Les, Marcin, Dubin, Grzegorz, Holak, Tad A., Skalniak, Lukasz
Publicado 2017

Human and mouse PD-L1: similar molecular structure, but different druggability profiles

por Magiera-Mularz, Katarzyna, Kocik, Justyna, Musielak, Bogdan, Plewka, Jacek, Sala, Dominik, Machula, Monika, Grudnik, Przemyslaw, Hajduk, Malgorzata, Czepiel, Marcin, Siedlar, Maciej, Holak, Tad A., Skalniak, Lukasz
Publicado 2020

Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule Fragments

por Kitel, Radoslaw, Rodríguez, Ismael, del Corte, Xabier, Atmaj, Jack, Żarnik, Magdalena, Surmiak, Ewa, Muszak, Damian, Magiera-Mularz, Katarzyna, Popowicz, Grzegorz M., Holak, Tad A., Musielak, Bogdan
Publicado 2022