Evolution of the immune system in humans from infancy to old age

por Simon, A. Katharina, Hollander, Georg A., McMichael, Andrew
Publicado 2015

Deficiency of the Metalloproteinase-Disintegrin ADAM8 Is Associated with Thymic Hyper-Cellularity

por Gossens, Klaus, Naus, Silvia, Holländer, Georg A., Ziltener, Hermann J.
Publicado 2010

Deletion of PKBα/Akt1 Affects Thymic Development

por Fayard, Elisabeth, Gill, Jason, Paolino, Magdalena, Hynx, Debby, Holländer, Georg A., Hemmings, Brian A.
Publicado 2007

Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation

por Kenins, Linda, Gill, Jason W., Boyd, Richard L., Holländer, Georg A., Wodnar-Filipowicz, Aleksandra
Publicado 2008

Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells

por Dhalla, Fatima, Baran‐Gale, Jeanette, Maio, Stefano, Chappell, Lia, Holländer, Georg A, Ponting, Chris P
Publicado 2019

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity

por Newman, Joseph A., Aitkenhead, Hazel, Gavard, Angeline E., Rota, Ioanna A., Handel, Adam E., Hollander, Georg A., Gileadi, Opher
Publicado 2020

RBFOX splicing factors contribute to a broad but selective recapitulation of peripheral tissue splicing patterns in the thymus

por Jansen, Kathrin, Shikama-Dorn, Noriko, Attar, Moustafa, Maio, Stefano, Lopopolo, Maria, Buck, David, Holländer, Georg A., Sansom, Stephen N.
Publicado 2021

Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development

por Handel, Adam E., Shikama-Dorn, Noriko, Zhanybekova, Saule, Maio, Stefano, Graedel, Annina N., Zuklys, Saulius, Ponting, Chris P., Holländer, Georg A.
Publicado 2018

Delta-like 4 is indispensable in thymic environment specific for T cell development

por Hozumi, Katsuto, Mailhos, Carolina, Negishi, Naoko, Hirano, Ken-ichi, Yahata, Takashi, Ando, Kiyoshi, Zuklys, Saulius, Holländer, Georg A., Shima, David T., Habu, Sonoko
Publicado 2008

Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

por Sansom, Stephen N., Shikama-Dorn, Noriko, Zhanybekova, Saule, Nusspaumer, Gretel, Macaulay, Iain C., Deadman, Mary E., Heger, Andreas, Ponting, Chris P., Holländer, Georg A.
Publicado 2014

Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development

por Stefanski, Heather E., Xing, Yan, Taylor, Patricia A., Maio, Stefano, Henao-Meija, Jorge, Williams, Adam, Flavell, Richard A., Hollander, Georg A., Blazar, Bruce R.
Publicado 2018

Thymus Extracellular Matrix‐Derived Scaffolds Support Graft‐Resident Thymopoiesis and Long‐Term In Vitro Culture of Adult Thymic Epithelial Cells

por Asnaghi, M. Adelaide, Barthlott, Thomas, Gullotta, Fabiana, Strusi, Valentina, Amovilli, Anna, Hafen, Katrin, Srivastava, Gitika, Oertle, Philipp, Toni, Roberto, Wendt, David, Holländer, Georg A., Martin, Ivan
Publicado 2021

Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells

por Satoh, Rumi, Kakugawa, Kiyokazu, Yasuda, Takuwa, Yoshida, Hisahiro, Sibilia, Maria, Katsura, Yoshimoto, Levi, Ben, Abramson, Jakub, Koseki, Yoko, Koseki, Haruhiko, van Ewijk, Willem, Hollander, Georg A., Kawamoto, Hiroshi
Publicado 2016

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development

por Lei, Yu, Ripen, Adiratna Mat, Ishimaru, Naozumi, Ohigashi, Izumi, Nagasawa, Takashi, Jeker, Lukas T., Bösl, Michael R., Holländer, Georg A., Hayashi, Yoshio, de Waal Malefyt, Rene, Nitta, Takeshi, Takahama, Yousuke
Publicado 2011

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells

por Žuklys, Saulius, Handel, Adam, Zhanybekova, Saule, Govani, Fatima, Keller, Marcel, Maio, Stefano, Mayer, Carlos E., Teh, Hong Ying, Hafen, Katrin, Gallone, Giuseppe, Barthlott, Thomas, Ponting, Chris P., Holländer, Georg A.
Publicado 2016

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

por Barthlott, Thomas, Handel, Adam E., Teh, Hong Ying, Wirasinha, Rushika C., Hafen, Katrin, Žuklys, Saulius, Roch, Benoit, Orkin, Stuart H., de Villartay, Jean-Pierre, Daley, Stephen R., Holländer, Georg A.
Publicado 2021

P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss

por Stefanski, Heather E., Xing, Yan, Nicholls, Jemma, Jonart, Leslie, Goren, Emily, Taylor, Patricia A., Mills, Alea A., Riddle, Megan, McGrath, John, Tolar, Jakub, Hollander, Georg A., Blazar, Bruce R.
Publicado 2022

Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk

por White, Andrea J., Parnell, Sonia M., Handel, Adam, Maio, Stefano, Bacon, Andrea, Cosway, Emilie J., Lucas, Beth, James, Kieran D., Cowan, Jennifer E., Jenkinson, William E., Hollander, Georg A., Anderson, Graham
Publicado 2023

Dynamic spatio‐temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla

por Mayer, Carlos E., Žuklys, Saulius, Zhanybekova, Saule, Ohigashi, Izumi, Teh, Hong‐Ying, Sansom, Stephen N., Shikama‐Dorn, Noriko, Hafen, Katrin, Macaulay, Iain C., Deadman, Mary E., Ponting, Chris P., Takahama, Yousuke, Holländer, Georg A.
Publicado 2016

Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells

por Klein, Fabian, Veiga-Villauriz, Clara, Börsch, Anastasiya, Maio, Stefano, Palmer, Sam, Dhalla, Fatima, Handel, Adam E., Zuklys, Saulius, Calvo-Asensio, Irene, Musette, Lucas, Deadman, Mary E., White, Andrea J., Lucas, Beth, Anderson, Graham, Holländer, Georg A.
Publicado 2023