NRF2 in Viral Infection

por Herengt, Angela, Thyrsted, Jacob, Holm, Christian K.
Publicado 2021

STING palmitoylation as a therapeutic target

por Hansen, Anne Louise, Mukai, Kojiro, Schopfer, Francisco J., Taguchi, Tomohiko, Holm, Christian K.
Publicado 2019

The uric acid crystal receptor Clec12A potentiates type I interferon responses

por Li, Kai, Neumann, Konstantin, Duhan, Vikas, Namineni, Sukumar, Hansen, Anne Louise, Wartewig, Tim, Kurgyis, Zsuzsanna, Holm, Christian K., Heikenwalder, Mathias, Lang, Karl S., Ruland, Jürgen
Publicado 2019

Interleukin-21 Receptor Signalling Is Important for Innate Immune Protection against HSV-2 Infections

por Kratholm, Sine K., Iversen, Marie B., Reinert, Line, Jensen, Simon K., Hokland, Marianne, Andersen, Thomas, Rankin, Andrew, Young, Deborah, Frische, Sebastian, Paludan, Søren R., Holm, Christian K.
Publicado 2013

Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro

por Svenningsen, Esben B., Thyrsted, Jacob, Blay-Cadanet, Julia, Liu, Han, Lin, Shaoquan, Moyano-Villameriel, Jaime, Olagnier, David, Idorn, Manja, Paludan, Søren R., Holm, Christian K., Poulsen, Thomas B.
Publicado 2021

The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2

por Vierbuchen, Tim, Agarwal, Shiuli, Johnson, John L., Galia, Liraz, Lei, Xuqiu, Stein, Karina, Olagnier, David, Gaede, Karoline I., Herzmann, Christian, Holm, Christian K., Heine, Holger, Pai, Athma, O’Hara Hall, Aisling, Hoebe, Kasper, Fitzgerald, Katherine A.
Publicado 2022

T Cells Detect Intracellular DNA but Fail to Induce Type I IFN Responses: Implications for Restriction of HIV Replication

por Berg, Randi K., Rahbek, Stine H., Kofod-Olsen, Emil, Holm, Christian K., Melchjorsen, Jesper, Jensen, David G., Hansen, Anne Louise, Jørgensen, Louise B., Ostergaard, Lars, Tolstrup, Martin, Larsen, Carsten S., Paludan, Søren R., Jakobsen, Martin R., Mogensen, Trine H.
Publicado 2014

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING

por Holm, Christian K, Jensen, Søren B, Jakobsen, Martin R, Cheshenko, Natalia, Horan, Kristy A, Moeller, Hanne B, Gonzalez-Dosal, Regina, Rasmussen, Simon B, Christensen, Maria H., Yarovinsky, Timur O, Rixon, Frazer J, Herold, Betsy C, Fitzgerald, Katherine A, Paludan, Søren R
Publicado 2012

Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signaling

por Nandakumar, Ramya, Tschismarov, Roland, Meissner, Felix, Prabakaran, Thaneas, Krissanaprasit, Abhichart, Farahani, Ensieh, Zhang, Bao-cun, Assil, Sonia, Martin, Amandine, Bertrams, Wilhelm, Holm, Christian K, Ablasser, Andrea, Klause, Tanja, Thomsen, Martin K, Schmeck, Bernd, Howard, Kenneth A, Henry, Thomas, Gothelf, Kurt V, Decker, Thomas, Paludan, Søren R
Publicado 2019

A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology

por Prabakaran, Thaneas, Troldborg, Anne, Kumpunya, Sarinya, Alee, Isara, Marinković, Emilija, Windross, Samuel J., Nandakumar, Ramya, Narita, Ryo, Zhang, Bao-cun, Carstensen, Mikkel, Vejvisithsakul, Pichpisith, Marqvorsen, Mikkel H.S., Iversen, Marie B., Holm, Christian K., Østergaard, Lars J., Pedersen, Finn Skou, Pisitkun, Trairak, Behrendt, Rayk, Pisitkun, Prapaporn, Paludan, Søren R.
Publicado 2021

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

por Holm, Christian K., Rahbek, Stine H., Gad, Hans Henrik, Bak, Rasmus O., Jakobsen, Martin R., Jiang, Zhaozaho, Hansen, Anne Louise, Jensen, Simon K., Sun, Chenglong, Thomsen, Martin K., Laustsen, Anders, Nielsen, Camilla G., Severinsen, Kasper, Xiong, Yingluo, Burdette, Dara L., Hornung, Veit, Lebbink, Robert Jan, Duch, Mogens, Fitzgerald, Katherine A., Bahrami, Shervin, Mikkelsen, Jakob Giehm, Hartmann, Rune, Paludan, Søren R.
Publicado 2016

TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection

por van der Sluis, Renée M, Cham, Lamin B, Gris‐Oliver, Albert, Gammelgaard, Kristine R, Pedersen, Jesper G, Idorn, Manja, Ahmadov, Ulvi, Hernandez, Sabina Sanches, Cémalovic, Ena, Godsk, Stine H, Thyrsted, Jacob, Gunst, Jesper D, Nielsen, Silke D, Jørgensen, Janni J, Bjerg, Tobias Wang, Laustsen, Anders, Reinert, Line S, Olagnier, David, Bak, Rasmus O, Kjolby, Mads, Holm, Christian K, Tolstrup, Martin, Paludan, Søren R, Kristensen, Lasse S, Søgaard, Ole S, Jakobsen, Martin R
Publicado 2022

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

por Hansen, Anne Louise, Buchan, Gregory J., Rühl, Michael, Mukai, Kojiro, Salvatore, Sonia R., Ogawa, Emari, Andersen, Sidsel D., Iversen, Marie B., Thielke, Anne L., Gunderstofte, Camilla, Motwani, Mona, Møller, Charlotte T., Jakobsen, Andreas S., Fitzgerald, Katherine A., Roos, Jessica, Lin, Rongtuan, Maier, Thorsten J., Goldbach-Mansky, Raphaela, Miner, Cathrine A., Qian, Wei, Miner, Jonathan J., Rigby, Rachel E., Rehwinkel, Jan, Jakobsen, Martin R., Arai, Hiroyuki, Taguchi, Tomohiko, Schopfer, Francisco J., Olagnier, David, Holm, Christian K.
Publicado 2018

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

por Olagnier, David, Brandtoft, Aske M., Gunderstofte, Camilla, Villadsen, Nikolaj L., Krapp, Christian, Thielke, Anne L., Laustsen, Anders, Peri, Suraj, Hansen, Anne Louise, Bonefeld, Lene, Thyrsted, Jacob, Bruun, Victor, Iversen, Marie B., Lin, Lin, Artegoitia, Virginia M., Su, Chenhe, Yang, Long, Lin, Rongtuan, Balachandran, Siddharth, Luo, Yonglun, Nyegaard, Mette, Marrero, Bernadette, Goldbach-Mansky, Raphaela, Motwani, Mona, Ryan, Dylan G., Fitzgerald, Katherine A., O’Neill, Luke A., Hollensen, Anne K., Damgaard, Christian K., de Paoli, Frank v., Bertram, Hanne C., Jakobsen, Martin R., Poulsen, Thomas B., Holm, Christian K.
Publicado 2018

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

por Olagnier, David, Farahani, Ensieh, Thyrsted, Jacob, Blay-Cadanet, Julia, Herengt, Angela, Idorn, Manja, Hait, Alon, Hernaez, Bruno, Knudsen, Alice, Iversen, Marie Beck, Schilling, Mirjam, Jørgensen, Sofie E., Thomsen, Michelle, Reinert, Line S., Lappe, Michael, Hoang, Huy-Dung, Gilchrist, Victoria H., Hansen, Anne Louise, Ottosen, Rasmus, Nielsen, Camilla G., Møller, Charlotte, van der Horst, Demi, Peri, Suraj, Balachandran, Siddharth, Huang, Jinrong, Jakobsen, Martin, Svenningsen, Esben B., Poulsen, Thomas B., Bartsch, Lydia, Thielke, Anne L., Luo, Yonglun, Alain, Tommy, Rehwinkel, Jan, Alcamí, Antonio, Hiscott, John, Mogensen, Trine, Paludan, Søren R., Holm, Christian K.
Publicado 2020

Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

por Olagnier, David, Farahani, Ensieh, Thyrsted, Jacob, Blay-Cadanet, Julia, Herengt, Angela, Idorn, Manja, Hait, Alon, Hernaez, Bruno, Knudsen, Alice, Iversen, Marie Beck, Schilling, Mirjam, Jørgensen, Sofie E., Thomsen, Michelle, Reinert, Line S., Lappe, Michael, Hoang, Huy-Dung, Gilchrist, Victoria H., Hansen, Anne Louise, Ottosen, Rasmus, Nielsen, Camilla G., Møller, Charlotte, van der Horst, Demi, Peri, Suraj, Balachandran, Siddharth, Huang, Jinrong, Jakobsen, Martin, Svenningsen, Esben B., Poulsen, Thomas B., Bartsch, Lydia, Thielke, Anne L., Luo, Yonglun, Alain, Tommy, Rehwinkel, Jan, Alcamí, Antonio, Hiscott, John, Mogensen, Trine H., Paludan, Søren R., Holm, Christian K.
Publicado 2020