Intranasal Delivery of Oncolytic Adenovirus XVir-N-31 via Optimized Shuttle Cells Significantly Extends Survival of Glioblastoma-Bearing Mice

por El-Ayoubi, Ali, Klawitter, Moritz, Rüttinger, Jakob, Wellhäusser, Giulia, Holm, Per Sonne, Danielyan, Lusine, Naumann, Ulrike
Publicado 2023

Concepts in Oncolytic Adenovirus Therapy

por Mantwill, Klaus, Klein, Florian Gerhard, Wang, Dongbiao, Hindupur, Sruthi Vasantamadhava, Ehrenfeld, Maximilian, Holm, Per Sonne, Nawroth, Roman
Publicado 2021

Functional genomics identifies predictive markers and clinically actionable resistance mechanisms to CDK4/6 inhibition in bladder cancer

por Tong, Zhichao, Sathe, Anuja, Ebner, Benedikt, Qi, Pan, Veltkamp, Christian, Gschwend, Juergen E., Holm, Per Sonne, Nawroth, Roman
Publicado 2019

Irradiation enhances the therapeutic effect of the oncolytic adenovirus XVir-N-31 in brain tumor initiating cells

por Czolk, Rebecca, Schwarz, Niklas, Koch, Henner, Schötterl, Sonja, Wuttke, Thomas V., Holm, Per S., Huber, Stephan M., Naumann, Ulrike
Publicado 2019

Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses

por Ungerechts, Guy, Bossow, Sascha, Leuchs, Barbara, Holm, Per S, Rommelaere, Jean, Coffey, Matt, Coffin, Rob, Bell, John, Nettelbeck, Dirk M
Publicado 2016

Combination of Talazoparib and Palbociclib as a Potent Treatment Strategy in Bladder Cancer

por Klein, Florian G., Granier, Charlène, Zhao, Yuling, Pan, Qi, Tong, Zhichao, Gschwend, Jürgen E., Holm, Per Sonne, Nawroth, Roman
Publicado 2021

YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells

por Mantwill, Klaus, Naumann, Ulrike, Seznec, Janina, Girbinger, Vroni, Lage, Hermann, Surowiak, Pawel, Beier, Dagmar, Mittelbronn, Michel, Schlegel, Jürgen, Holm, Per Sonne
Publicado 2013

EGFR-Targeted Adenovirus Dendrimer Coating for Improved Systemic Delivery of the Theranostic NIS Gene

por Grünwald, Geoffrey K, Vetter, Alexandra, Klutz, Kathrin, Willhauck, Michael J, Schwenk, Nathalie, Senekowitsch-Schmidtke, Reingard, Schwaiger, Markus, Zach, Christian, Wagner, Ernst, Göke, Burkhard, Holm, Per S, Ogris, Manfred, Spitzweg, Christine
Publicado 2013

STAT3/5 Inhibitors Suppress Proliferation in Bladder Cancer and Enhance Oncolytic Adenovirus Therapy

por Hindupur, Sruthi V., Schmid, Sebastian C., Koch, Jana Annika, Youssef, Ahmed, Baur, Eva-Maria, Wang, Dongbiao, Horn, Thomas, Slotta-Huspenina, Julia, Gschwend, Juergen E., Holm, Per Sonne, Nawroth, Roman
Publicado 2020

The Oncolytic Adenovirus XVir-N-31, in Combination with the Blockade of the PD-1/PD-L1 Axis, Conveys Abscopal Effects in a Humanized Glioblastoma Mouse Model

por Klawitter, Moritz, El-Ayoubi, Ali, Buch, Jasmin, Rüttinger, Jakob, Ehrenfeld, Maximilian, Lichtenegger, Eva, Krüger, Marcel A., Mantwill, Klaus, Koll, Florestan J., Kowarik, Markus C., Holm, Per Sonne, Naumann, Ulrike
Publicado 2022

Targeting the Retinoblastoma/E2F repressive complex by CDK4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus

por Koch, Jana, Schober, Sebastian J., Hindupur, Sruthi V., Schöning, Caroline, Klein, Florian G., Mantwill, Klaus, Ehrenfeld, Maximilian, Schillinger, Ulrike, Hohnecker, Timmy, Qi, Pan, Steiger, Katja, Aichler, Michaela, Gschwend, Jürgen E., Nawroth, Roman, Holm, Per Sonne
Publicado 2022

Virotherapy in Germany—Recent Activities in Virus Engineering, Preclinical Development, and Clinical Studies

por Nettelbeck, Dirk M., Leber, Mathias F., Altomonte, Jennifer, Angelova, Assia, Beil, Julia, Berchtold, Susanne, Delic, Maike, Eberle, Jürgen, Ehrhardt, Anja, Engeland, Christine E., Fechner, Henry, Geletneky, Karsten, Goepfert, Katrin, Holm, Per Sonne, Kochanek, Stefan, Kreppel, Florian, Krutzke, Lea, Kühnel, Florian, Lang, Karl Sebastian, Marchini, Antonio, Moehler, Markus, Mühlebach, Michael D., Naumann, Ulrike, Nawroth, Roman, Nüesch, Jürg, Rommelaere, Jean, Lauer, Ulrich M., Ungerechts, Guy
Publicado 2021