IntReALL HR and the benefits of adaptive design

por Holmes, Jane, Love, Sharon, Saha, Vaskar, von Stackelberg, Arend
Publicado 2015

Challenges in implementing model-based phase I designs in a grant-funded clinical trials unit

por Frangou, Eleni, Holmes, Jane, Love, Sharon, McGregor, Naomi, Hawkins, Maria
Publicado 2017

Randomised phase II trial of olaparib, chemotherapy or olaparib and cediranib in patients with platinum-resistant ovarian cancer (OCTOVA): a study protocol

por Mansouri, Anita, McGregor, Naomi, Dunn, Rachel, Dobbie, Sam, Holmes, Jane, Collins, Linda, Nicum, Shibani
Publicado 2021

Practicalities in running early-phase trials using the time-to-event continual reassessment method (TiTE-CRM) for interventions with long toxicity periods using two radiotherapy on...

por van Werkhoven, Erik, Hinsley, Samantha, Frangou, Eleni, Holmes, Jane, de Haan, Rosemarie, Hawkins, Maria, Brown, Sarah, Love, Sharon B
Publicado 2020

A phase II open label, randomised study of ipilimumab with temozolomide versus temozolomide alone after surgery and chemoradiotherapy in patients with recently diagnosed glioblasto...

por Brown, Nicholas F., Ng, Stasya M., Brooks, Claire, Coutts, Tim, Holmes, Jane, Roberts, Corran, Elhussein, Leena, Hoskin, Peter, Maughan, Tim, Blagden, Sarah, Mulholland, Paul
Publicado 2020

A phase 1 trial of the safety, tolerability and biological effects of intravenous Enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced...

por O’Cathail, Séan M., Davis, Steven, Holmes, Jane, Brown, Richard, Fisher, Kerry, Seymour, Leonard, Adams, Richard, Good, James, Sebag-Montefiore, David, Maughan, Tim, Hawkins, Maria A.
Publicado 2020

A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell’s viper antivenom in Myanmar

por Watson, James A., Lamb, Thomas, Holmes, Jane, Warrell, David A., Thwin, Khin Thida, Aung, Zaw Lynn, Oo, Min Zaw, Nwe, Myat Thet, Smithuis, Frank, Ashley, Elizabeth A.
Publicado 2020

Overinterpretation and misreporting of prognostic factor studies in oncology: a systematic review

por Kempf, Emmanuelle, de Beyer, Jennifer A., Cook, Jonathan, Holmes, Jane, Mohammed, Seid, Nguyên, Tri-Long, Simera, Iveta, Trivella, Marialena, Altman, Douglas G., Hopewell, Sally, Moons, Karel G. M., Porcher, Raphael, Reitsma, Johannes B., Sauerbrei, Willi, Collins, Gary S.
Publicado 2018

Adaptive designs in clinical trials: why use them, and how to run and report them

por Pallmann, Philip, Bedding, Alun W., Choodari-Oskooei, Babak, Dimairo, Munyaradzi, Flight, Laura, Hampson, Lisa V., Holmes, Jane, Mander, Adrian P., Odondi, Lang’o, Sydes, Matthew R., Villar, Sofía S., Wason, James M. S., Weir, Christopher J., Wheeler, Graham M., Yap, Christina, Jaki, Thomas
Publicado 2018

Early phase clinical trials extension to guidelines for the content of statistical analysis plans

por Homer, Victoria, Yap, Christina, Bond, Simon, Holmes, Jane, Stocken, Deborah, Walker, Katrina, Robinson, Emily J, Wheeler, Graham, Brown, Sarah, Hinsley, Samantha, Schipper, Matthew, Weir, Christopher J, Rantell, Khadija, Prior, Thomas, Yu, Ly-Mee, Kirkpatrick, John, Bedding, Alun, Gamble, Carrol, Gaunt, Piers
Publicado 2022

A Cross-Sectional Observational Study of Pneumococcal Carriage in Children, Their Parents, and Older Adults Following the Introduction of the 7-Valent Pneumococcal Conjugate Vaccin...

por Hamaluba, Mainga, Kandasamy, Rama, Ndimah, Susan, Morton, Richard, Caccamo, Marisa, Robinson, Hannah, Kelly, Sarah, Field, Aimee, Norman, Lily, Plested, Emma, Thompson, Ben A.V., Zafar, Azhar, Kerridge, Simon A., Lazarus, Rajeka, John, Tessa, Holmes, Jane, Fenlon, Shannon N., Gould, Katherine A., Waight, Pauline, Hinds, Jason, Crook, Derrick, Snape, Matthew D., Pollard, Andrew J.
Publicado 2015

Effect of age and sex on efficacy and tolerability of β blockers in patients with heart failure with reduced ejection fraction: individual patient data meta-analysis

por Kotecha, Dipak, Manzano, Luis, Krum, Henry, Rosano, Giuseppe, Holmes, Jane, Altman, Douglas G, Collins, Peter D, Packer, Milton, Wikstrand, John, Coats, Andrew J S, Cleland, John G F, Kirchhof, Paulus, von Lueder, Thomas G, Rigby, Alan S, Andersson, Bert, Lip, Gregory YH, van Veldhuisen, Dirk J, Shibata, Marcelo C, Wedel, Hans, Böhm, Michael, Flather, Marcus D
Publicado 2016

Visualising harms in publications of randomised controlled trials: consensus and recommendations

por Phillips, Rachel, Cro, Suzie, Wheeler, Graham, Bond, Simon, Morris, Tim P, Creanor, Siobhan, Hewitt, Catherine, Love, Sharon, Lopes, Andre, Schlackow, Iryna, Gamble, Carrol, MacLennan, Graeme, Habron, Chris, Gordon, Anthony C, Vergis, Nikhil, Li, Tianjing, Qureshi, Riaz, Everett, Colin C, Holmes, Jane, Kirkham, Amanda, Peckitt, Clare, Pirrie, Sarah, Ahmed, Norin, Collett, Laura, Cornelius, Victoria
Publicado 2022

Effect of moderate to high intensity aerobic exercise on blood pressure in young adults: The TEPHRA open, two-arm, parallel superiority randomized clinical trial

por Williamson, Wilby, Lewandowski, Adam James, Huckstep, Odaro John, Lapidaire, Winok, Ooms, Alexander, Tan, Cheryl, Mohamed, Afifah, Alsharqi, Maryam, Bertagnolli, Mariane, Woodward, William, Dockerill, Cameron, McCourt, Annabelle, Kenworthy, Yvonne, Burchert, Holger, Doherty, Aiden, Newton, Julia, Hanssen, Henner, Cruickshank, John Kennedy, McManus, Richard, Holmes, Jane, Ji, Chen, Love, Sharon, Frangou, Elena, Everett, Colin, Hillsdon, Melvyn, Dawes, Helen, Foster, Charlie, Leeson, Paul
Publicado 2022

Antivirals for influenza-Like Illness? A randomised Controlled trial of Clinical and Cost effectiveness in primary CarE (ALIC(4) E): the ALIC(4) E protocol

por Bongard, Emily, van der Velden, Alike W, Cook, Johanna, Saville, Ben, Beutels, Philippe, Munck Aabenhus, Rune, Brugman, Curt, Chlabicz, Slawomir, Coenen, Samuel, Colliers, Annelies, Davies, Melanie, De Paor, Muireann, De Sutter, An, Francis, Nick A, Glinz, Dominik, Godycki-ćwirko, Maciek, Goossens, Herman, Holmes, Jane, Ieven, Margareta, de Jong, Menno, Lindbaek, Morten, Little, Paul, Martinón-Torres, Frederico, Moragas, Ana, Pauer, József, Pfeiferová, Markéta, Radzeviciene-Jurgute, Ruta, Sundvall, Pär-Daniel, Torres, Antoni, Touboul, Pia, Varthalis, Dionyssios, Verheij, Theo, Butler, Christopher C
Publicado 2018

Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial...

por Gbinigie, Oghenekome, Ogburn, Emma, Allen, Julie, Dorward, Jienchi, Dobson, Melissa, Madden, Tracie-Ann, Yu, Ly-Mee, Lowe, David M, Rahman, Najib, Petrou, Stavros, Richards, Duncan, Hood, Kerenza, Patel, Mahendra, Saville, Benjamin R, Marion, Joe, Holmes, Jane, Png, May Ee, Hayward, Gail, Lown, Mark, Harris, Victoria, Jani, Bhautesh, Hart, Nigel, Khoo, Saye, Rutter, Heather, Chalk, Jem, Standing, Joseph F, Breuer, Judith, Lavallee, Layla, Hadley, Elizabeth, Cureton, Lucy, Benysek, Magdalena, Andersson, Monique I, Francis, Nick, Thomas, Nicholas P B, Evans, Philip, van Hecke, Oliver, Koshkouei, Mona, Coates, Maria, Barrett, Sarah, Bateman, Clare, Davies, Jennifer, Raymundo-Wood, Ivy, Ustianowski, Andrew, Nguyen-Van-Tam, Jonathan, Carson-Stevens, Andrew, Hobbs, Richard, Little, Paul, Butler, Christopher C
Publicado 2023

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive...

por Butler, Christopher C, Hobbs, F D Richard, Gbinigie, Oghenekome A, Rahman, Najib M, Hayward, Gail, Richards, Duncan B, Dorward, Jienchi, Lowe, David M, Standing, Joseph F, Breuer, Judith, Khoo, Saye, Petrou, Stavros, Hood, Kerenza, Nguyen-Van-Tam, Jonathan S, Patel, Mahendra G, Saville, Benjamin R, Marion, Joe, Ogburn, Emma, Allen, Julie, Rutter, Heather, Francis, Nick, Thomas, Nicholas P B, Evans, Philip, Dobson, Melissa, Madden, Tracie-Ann, Holmes, Jane, Harris, Victoria, Png, May Ee, Lown, Mark, van Hecke, Oliver, Detry, Michelle A, Saunders, Christina T, Fitzgerald, Mark, Berry, Nicholas S, Mwandigha, Lazaro, Galal, Ushma, Mort, Sam, Jani, Bhautesh D, Hart, Nigel D, Ahmed, Haroon, Butler, Daniel, McKenna, Micheal, Chalk, Jem, Lavallee, Layla, Hadley, Elizabeth, Cureton, Lucy, Benysek, Magdalena, Andersson, Monique, Coates, Maria, Barrett, Sarah, Bateman, Clare, Davies, Jennifer C, Raymundo-Wood, Ivy, Ustianowski, Andrew, Carson-Stevens, Andrew, Yu, Ly-Mee, Little, Paul
Publicado 2023