Targeting the Isoprenoid Biosynthetic Pathway in Multiple Myeloma

por Haney, Staci L., Holstein, Sarah A.
Publicado 2022

Geranylgeranyl diphosphate synthase: Role in human health, disease and potential therapeutic target

por Muehlebach, Molly E., Holstein, Sarah A.
Publicado 2023

Targeting HSP90 and monoclonal protein trafficking modulates the unfolded protein response, chaperone regulation and apoptosis in myeloma cells

por Born, E J, Hartman, S V, Holstein, S A
Publicado 2013

Modeling the Effects of Multiple Myeloma on Kidney Function

por Walk, Julia C., Ayati, Bruce P., Holstein, Sarah A.
Publicado 2019

Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors

por Haney, Staci L., Wills, Veronica S., Wiemer, David F., Holstein, Sarah A.
Publicado 2017

The Role of Osteocytes in Targeted Bone Remodeling: A Mathematical Model

por Graham, Jason M., Ayati, Bruce P., Holstein, Sarah A., Martin, James A.
Publicado 2013

Future Directions in Maintenance Therapy in Multiple Myeloma

por Holstein, Sarah A., Suman, Vera J., Hillengass, Jens, McCarthy, Philip L.
Publicado 2021

Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells

por Dykstra, Kaitlyn M., Allen, Cheryl, Born, Ella J., Tong, Huaxiang, Holstein, Sarah A.
Publicado 2015

Simultaneous Quantitation of Isoprenoid Pyrophosphates in Plasma and Cancer Cells Using LC-MS/MS

por Chhonker, Yashpal S., Haney, Staci L., Bala, Veenu, Holstein, Sarah A., Murry, Daryl J.
Publicado 2018

Geranylgeranyl diphosphate synthase inhibitor and proteasome inhibitor combination therapy in multiple myeloma

por Haney, Staci L., Varney, Michelle L., Williams, Jacob T., Smith, Lynette M., Talmon, Geoffrey, Holstein, Sarah A.
Publicado 2022

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

por Haney, Staci L., Varney, Michelle L., Chhonker, Yashpal S., Shin, Simon, Mehla, Kamiya, Crawford, Ayrianne J., Smith, Heather Jensen, Smith, Lynette M., Murry, Daryl J., Hollingsworth, Michael A., Holstein, Sarah A.
Publicado 2019

PB2129: THE MODAKAFUSP ALFA IINNOVATE CLINICAL DEVELOPMENT PROGRAM: RATIONALE AND DESIGN OF 3 PHASE 1/2 TRIALS OF AN INNATE IMMUNITY ENHANCER FOR MULTIPLE MYELOMA (MM)

por Holstein, Sarah A., Mian, Hira, Touzeau, Cyrille, Kingsley, Edwin, Vogl, Dan, Zuniga, Richard, Suryanarayan, Kaveri, Wang, Shining, Thesillat-Versmee, Laura, Liu, Yuyin, Chen, Tian, Zhang, Yefei, Parot, Xavier, Lee, Hans C.
Publicado 2023

Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells

por Haney, Staci L., Allen, Cheryl, Varney, Michelle L., Dykstra, Kaitlyn M., Falcone, Eric R., Colligan, Sean H., Hu, Qiang, Aldridge, Alyssa M., Wright, Dennis L., Wiemer, Andrew J., Holstein, Sarah A.
Publicado 2017

The Peptide–Drug Conjugate Melflufen Modulates the Unfolded Protein Response of Multiple Myeloma and Amyloidogenic Plasma Cells and Induces Cell Death

por Flanagan, Ken, Kumari, Romika, Miettinen, Juho J., Haney, Staci L., Varney, Michelle L., Williams, Jacob T., Majumder, Muntasir M., Suvela, Minna, Slipicevic, Ana, Lehmann, Fredrik, Nupponen, Nina N., Holstein, Sarah A., Heckman, Caroline A.
Publicado 2022

Daratumumab plus lenalidomide/bortezomib/dexamethasone in Black patients with transplant-eligible newly diagnosed multiple myeloma in GRIFFIN

por Nooka, Ajay K., Kaufman, Jonathan L., Rodriguez, Cesar, Jakubowiak, Andrzej, Efebera, Yvonne, Reeves, Brandi, Wildes, Tanya, Holstein, Sarah A., Anderson, Larry D., Badros, Ashraf, Shune, Leyla, Chari, Ajai, Pei, Huiling, Cortoos, Annelore, Patel, Sharmila, Bartlett, J. Blake, Vermeulen, Jessica, Lin, Thomas S., Richardson, Paul G., Voorhees, Peter
Publicado 2022

The Ribosomal Protein Rpl22 Controls Ribosome Composition by Directly Repressing Expression of Its Own Paralog, Rpl22l1

por O'Leary, Monique N., Schreiber, Katherine H., Zhang, Yong, Duc, Anne-Cécile E., Rao, Shuyun, Hale, J. Scott, Academia, Emmeline C., Shah, Shreya R., Morton, John F., Holstein, Carly A., Martin, Dan B., Kaeberlein, Matt, Ladiges, Warren C., Fink, Pamela J., MacKay, Vivian L., Wiest, David L., Kennedy, Brian K.
Publicado 2013

Daratumumab plus lenalidomide, bortezomib and dexamethasone in newly diagnosed multiple myeloma: Analysis of vascular thrombotic events in the GRIFFIN study

por Sborov, Douglas W., Baljevic, Muhamed, Reeves, Brandi, Laubach, Jacob, Efebera, Yvonne A., Rodriguez, Cesar, Costa, Luciano J., Chari, Ajai, Silbermann, Rebecca, Holstein, Sarah A., Anderson, Larry D., Kaufman, Jonathan L., Shah, Nina, Pei, Huiling, Patel, Sharmila, Cortoos, Annelore, Bartlett, J. Blake, Vermeulen, Jessica, Lin, Thomas S., Voorhees, Peter M., Richardson, Paul G.
Publicado 2022

Developments in continuous therapy and maintenance treatment approaches for patients with newly diagnosed multiple myeloma

por Dimopoulos, Meletios A., Jakubowiak, Andrzej J., McCarthy, Philip L., Orlowski, Robert Z., Attal, Michel, Bladé, Joan, Goldschmidt, Hartmut, Weisel, Katja C., Ramasamy, Karthik, Zweegman, Sonja, Spencer, Andrew, Huang, Jeffrey S. Y., Lu, Jin, Sunami, Kazutaka, Iida, Shinsuke, Chng, Wee-Joo, Holstein, Sarah A., Rocci, Alberto, Skacel, Tomas, Labotka, Richard, Palumbo, Antonio, Anderson, Kenneth C.
Publicado 2020

Updated analysis of CALGB 100104 (Alliance): a randomised phase III study evaluating lenalidomide vs placebo maintenance after single autologous stem cell transplant for multiple m...

por Holstein, Sarah A., Jung, Sin-Ho, Richardson, Paul G., Hofmeister, Craig C., Hurd, David D., Hassoun, Hani, Giralt, Sergio, Stadtmauer, Edward A., Weisdorf, Daniel J., Vij, Ravi, Moreb, Jan S., Callander, Natalie S., van Besien, Koen, Gentile, Teresa G., Isola, Luis, Maziarz, Richard T, Bashey, Asad, Landau, Heather, Martin, Thomas, Qazilbash, Muzaffar H, Rodriguez, Cesar, McClune, Brian, Schlossman, Robert L., Smith, Scott E., Hars, Vera, Owzar, Kouros, Jiang, Chen, Boyd, Molly, Schultz, Chelsea, Wilson, Marcia, Hari, Parameswaran, Pasquini, Marcelo C., Horowitz, Mary M., Shea, Thomas C., Devine, Steven M., Linker, Charles, Anderson, Kenneth C., McCarthy, Philip L.
Publicado 2017