The mitochondrial R-loop

por Holt, Ian J
Publicado 2019

A robust assay to measure DNA topology-dependent protein binding affinity

por Litwin, Tamara R., Solà, Maria, Holt, Ian J., Neuman, Keir C.
Publicado 2015

Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts

por Reyes, Aurelio, Kazak, Lawrence, Wood, Stuart R., Yasukawa, Takehiro, Jacobs, Howard T., Holt, Ian J.
Publicado 2013

Transmission of Mitochondrial DNA Diseases and Ways to Prevent Them

por Poulton, Joanna, Chiaratti, Marcos R., Meirelles, Flávio V., Kennedy, Stephen, Wells, Dagan, Holt, Ian J.
Publicado 2010

Mitochondrial Transcription Terminator Family Members mTTF and mTerf5 Have Opposing Roles in Coordination of mtDNA Synthesis

por Jõers, Priit, Lewis, Samantha C., Fukuoh, Atsushi, Parhiala, Mikael, Ellilä, Simo, Holt, Ian J., Jacobs, Howard T.
Publicado 2013

A Cryptic Targeting Signal Creates a Mitochondrial FEN1 Isoform with Tailed R-Loop Binding Properties

por Kazak, Lawrence, Reyes, Aurelio, He, Jiuya, Wood, Stuart R., Brea-Calvo, Gloria, Holen, Torgeir T., Holt, Ian J.
Publicado 2013

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA

por Bailey, Laura J., Cluett, Tricia J., Reyes, Aurelio, Prolla, Tom A., Poulton, Joanna, Leeuwenburgh, Christiaan, Holt, Ian J.
Publicado 2009

Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells

por Pohjoismäki, Jaakko L. O., Wanrooij, Sjoerd, Hyvärinen, Anne K., Goffart, Steffi, Holt, Ian J., Spelbrink, Johannes N., Jacobs, Howard T.
Publicado 2006

Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria

por Sharma, Nilesh K., Reyes, Aurelio, Green, Paula, Caron, Matthieu J., Bonini, Marcelo G., Gordon, Donna M., Holt, Ian J., Santos, Janine Hertzog
Publicado 2012

Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication

por Cluett, Tricia J, Akman, Gokhan, Reyes, Aurelio, Kazak, Lawrence, Mitchell, Alice, Wood, Stuart R, Spinazzola, Antonella, Spelbrink, Johannes N, Holt, Ian J
Publicado 2018

The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA

por Hyvärinen, Anne K., Pohjoismäki, Jaakko L. O., Reyes, Aurelio, Wanrooij, Sjoerd, Yasukawa, Takehiro, Karhunen, Pekka J., Spelbrink, Johannes N., Holt, Ian J., Jacobs, Howard T.
Publicado 2007

TEFM (c17orf42) is necessary for transcription of human mtDNA

por Minczuk, Michal, He, Jiuya, Duch, Anna M., Ettema, Thijs J., Chlebowski, Aleksander, Dzionek, Karol, Nijtmans, Leo G. J., Huynen, Martijn A., Holt, Ian J.
Publicado 2011

Alternative translation initiation augments the human mitochondrial proteome

por Kazak, Lawrence, Reyes, Aurelio, Duncan, Anna L., Rorbach, Joanna, Wood, Stuart R., Brea-Calvo, Gloria, Gammage, Payam A., Robinson, Alan J., Minczuk, Michal, Holt, Ian J.
Publicado 2013

Amino Acid Starvation Has Opposite Effects on Mitochondrial and Cytosolic Protein Synthesis

por Johnson, Mark A., Vidoni, Sara, Durigon, Romina, Pearce, Sarah F., Rorbach, Joanna, He, Jiuya, Brea-Calvo, Gloria, Minczuk, Michal, Reyes, Aurelio, Holt, Ian J., Spinazzola, Antonella
Publicado 2014

Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure

por Gerhold, Joachim M., Cansiz-Arda, Şirin, Lõhmus, Madis, Engberg, Oskar, Reyes, Aurelio, van Rennes, Helga, Sanz, Alberto, Holt, Ian J., Cooper, Helen M., Spelbrink, Johannes N.
Publicado 2015

Corrigendum: Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure

por Gerhold, Joachim M., Cansiz-Arda, Şirin, Lõhmus, Madis, Engberg, Oskar, Reyes, Aurelio, van Rennes, Helga, Sanz, Alberto, Holt, Ian J., Cooper, Helen M., Spelbrink, Johannes N.
Publicado 2015

Human Heart Mitochondrial DNA Is Organized in Complex Catenated Networks Containing Abundant Four-way Junctions and Replication Forks

por Pohjoismäki, Jaakko L. O., Goffart, Steffi, Tyynismaa, Henna, Willcox, Smaranda, Ide, Tomomi, Kang, Dongchon, Suomalainen, Anu, Karhunen, Pekka J., Griffith, Jack D., Holt, Ian J., Jacobs, Howard T.
Publicado 2009

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

por García-Gómez, Sara, Reyes, Aurelio, Martínez-Jiménez, María I., Chocrón, E. Sandra, Mourón, Silvana, Terrados, Gloria, Powell, Christopher, Salido, Eduardo, Méndez, Juan, Holt, Ian J., Blanco, Luis
Publicado 2013

LETM1 couples mitochondrial DNA metabolism and nutrient preference

por Durigon, Romina, Mitchell, Alice L, Jones, Aleck WE, Manole, Andreea, Mennuni, Mara, Hirst, Elizabeth MA, Houlden, Henry, Maragni, Giuseppe, Lattante, Serena, Doronzio, Paolo Niccolo’, Dalla Rosa, Ilaria, Zollino, Marcella, Holt, Ian J, Spinazzola, Antonella
Publicado 2018

2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart

por Aiestaran-Zelaia, Irati, Sánchez-Guisado, María Jesús, Villar-Fernandez, Marina, Azkargorta, Mikel, Fadon-Padilla, Lucia, Fernandez-Pelayo, Uxoa, Perez-Rodriguez, Diego, Ramos-Cabrer, Pedro, Spinazzola, Antonella, Elortza, Félix, Ruíz-Cabello, Jésus, Holt, Ian J.
Publicado 2022