The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model

por Holubova, Jana, Stanek, Ondrej, Juhasz, Attila, Hamidou Soumana, Illiassou, Makovicky, Peter, Sebo, Peter
Publicado 2022

Bordetella Adenylate Cyclase Toxin Inhibits Monocyte-to-Macrophage Transition and Dedifferentiates Human Alveolar Macrophages into Monocyte-like Cells

por Ahmad, Jawid Nazir, Holubova, Jana, Benada, Oldrich, Kofronova, Olga, Stehlik, Ludek, Vasakova, Martina, Sebo, Peter
Publicado 2019

Carbonyl Reduction of Flubendazole in the Human Liver: Strict Stereospecificity, Sex Difference, Low Risk of Drug Interactions

por Kubíček, Vladimír, Skálová, Lenka, Skarka, Adam, Králová, Věra, Holubová, Jana, Štěpánková, Jana, Šubrt, Zdeněk, Szotáková, Barbora
Publicado 2019

Selective Enhancement of the Cell-Permeabilizing Activity of Adenylate Cyclase Toxin Does Not Increase Virulence of Bordetella pertussis

por Holubova, Jana, Juhasz, Attila, Masin, Jiri, Stanek, Ondrej, Jurnecka, David, Osickova, Adriana, Sebo, Peter, Osicka, Radim
Publicado 2021

Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes

por Klimova, Nela, Holubova, Jana, Streparola, Gaia, Tomala, Jakub, Brazdilova, Ludmila, Stanek, Ondrej, Bumba, Ladislav, Sebo, Peter
Publicado 2022

Acellular Pertussis Vaccine Inhibits Bordetella pertussis Clearance from the Nasal Mucosa of Mice

por Holubová, Jana, Staněk, Ondřej, Brázdilová, Ludmila, Mašín, Jiří, Bumba, Ladislav, Gorringe, Andrew R., Alexander, Frances, Šebo, Peter
Publicado 2020

Filamentous Hemagglutinin of Bordetella pertussis Does Not Interact with the β(2) Integrin CD11b/CD18

por Golshani, Maryam, Rahman, Waheed Ur, Osickova, Adriana, Holubova, Jana, Lora, Jinery, Balashova, Nataliya, Sebo, Peter, Osicka, Radim
Publicado 2022

Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin

por Espinosa-Vinals, Carlos Angel, Masin, Jiri, Holubova, Jana, Stanek, Ondrej, Jurnecka, David, Osicka, Radim, Sebo, Peter, Bumba, Ladislav
Publicado 2021

Bordetella Adenylate Cyclase Toxin Elicits Airway Mucin Secretion through Activation of the cAMP Response Element Binding Protein

por Malandra, Anna, Rahman, Waheed Ur, Klimova, Nela, Streparola, Gaia, Holubova, Jana, Osickova, Adriana, Bariselli, Simone, Sebo, Peter, Osicka, Radim
Publicado 2021

Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue

por Bayram, Jan, Malcova, Ivana, Sinkovec, Larisa, Holubova, Jana, Streparola, Gaia, Jurnecka, David, Kucera, Jan, Sedlacek, Radislav, Sebo, Peter, Kamanova, Jana
Publicado 2020

Production of Highly Active Recombinant Dermonecrotic Toxin of Bordetella Pertussis

por Stanek, Ondrej, Linhartova, Irena, Holubova, Jana, Bumba, Ladislav, Gardian, Zdenko, Malandra, Anna, Bockova, Barbora, Teruya, Shihono, Horiguchi, Yasuhiko, Osicka, Radim, Sebo, Peter
Publicado 2020

A Mutation Upstream of the rplN-rpsD Ribosomal Operon Downregulates Bordetella pertussis Virulence Factor Production without Compromising Bacterial Survival within Human Macrophage...

por Novák, Jakub, Jurnečka, David, Linhartová, Irena, Holubová, Jana, Staněk, Ondřej, Štipl, Daniel, Dienstbier, Ana, Večerek, Branislav, Azevedo, Nayara, Provazník, Jan, Beneš, Vladimír, Šebo, Peter
Publicado 2020

RTX proteins: a highly diverse family secreted by a common mechanism

por Linhartová, Irena, Bumba, Ladislav, Mašín, Jiří, Basler, Marek, Osička, Radim, Kamanová, Jana, Procházková, Kateřina, Adkins, Irena, Hejnová-Holubová, Jana, Sadílková, Lenka, Morová, Jana, Šebo, Peter
Publicado 2010

Different roles of conserved tyrosine residues of the acylated domains in folding and activity of RTX toxins

por Lepesheva, Anna, Osickova, Adriana, Holubova, Jana, Jurnecka, David, Knoblochova, Sarka, Espinosa-Vinals, Carlos, Bumba, Ladislav, Skopova, Karolina, Fiser, Radovan, Osicka, Radim, Sebo, Peter, Masin, Jiri
Publicado 2021

Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination

por van Schuppen, Evi, Fröberg, Janeri, Venkatasubramanian, Prashanna Balaji, Versteegen, Pauline, de Graaf, Hans, Holubová, Jana, Gillard, Joshua, van Gageldonk, Pieter G. M., Joosten, Irma, de Groot, Ronald, Šebo, Peter, Berbers, Guy A. M., Read, Robert C., Huynen, Martijn A., de Jonge, Marien I., Diavatopoulos, Dimitri A.
Publicado 2022