Targeting phosphatases in cancer: suppression of many versus the ablation of one

por D’Arcy, Brandon M., Prakash, Aishwarya, Honkanen, Richard E.
Publicado 2019

Editorial: Deciphering the etiology of rare genetic disorders associated with protein phosphatases

por Janssens, Veerle, Wadzinski, Brian E., Li, Chenchen, Honkanen, Richard E.
Publicado 2023

Quantum-based modeling implies that bidentate Arg(89)-substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation

por Salter, E. Alan, Wierzbicki, Andrzej, Honkanen, Richard E., Swingle, Mark R.
Publicado 2023

Development of a Synthetic 3-ketosteroid Δ(1)-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells

por D’Arcy, Brandon M., Swingle, Mark R., Schambeau, Lindsay, Pannell, Lewis, Prakash, Aishwarya, Honkanen, Richard E.
Publicado 2019

Serine / threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling

por Dean, David A, Urban, Gudrun, Aragon, Ileana V, Swingle, Mark, Miller, Beth, Rusconi, Sandro, Bueno, Manuel, Dean, Nicholas M, Honkanen, Richard E
Publicado 2001

Calcineurin Regulates Homologous Desensitization of Natriuretic Peptide Receptor-A and Inhibits ANP-Induced Testosterone Production in MA-10 Cells

por Henesy, Michelle B., Britain, Andrea L., Zhu, Bing, Amable, Lauren, Honkanen, Richard E., Corbin, Jackie D., Francis, Sharron H., Rich, Thomas C.
Publicado 2012

Serine/threonine phosphatase 5 (PP5C/PPP5C) regulates the ISOC channel through a PP5C-FKBP51 axis

por Hamilton, Caleb L., Abney, Kevin A., Vasauskas, Audrey A., Alexeyev, Mikhail, Ni, Li, Honkanen, Richard E., Scammell, Jonathan G., Cioffi, Donna L.
Publicado 2017

Quantitative proteomics and phosphoproteomics of PP2A-PPP2R5D variants reveal deregulation of RPS6 phosphorylation via converging signaling cascades

por Smolen, Kali A., Papke, Cinta M., Swingle, Mark R., Musiyenko, Alla, Li, Chenchen, Salter, E. Alan, Camp, Ashley D., Honkanen, Richard E., Kettenbach, Arminja N.
Publicado 2023

A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth

por Papke, Cinta M., Smolen, Kali A., Swingle, Mark R., Cressey, Lauren, Heng, Richard A., Toporsian, Mourad, Deng, Liyong, Hagen, Jacob, Shen, Yufeng, Chung, Wendy K., Kettenbach, Arminja N., Honkanen, Richard E.
Publicado 2021

Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth

por Shuhaibar, Leia C., Kaci, Nabil, Egbert, Jeremy R., Horville, Thibault, Loisay, Léa, Vigone, Giulia, Uliasz, Tracy F., Dambroise, Emilie, Swingle, Mark R., Honkanen, Richard E., Duplan, Martin Biosse, Jaffe, Laurinda A., Legeai-Mallet, Laurence
Publicado 2021

Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme

por Wu, Cheng-Guo, Balakrishnan, Vijaya K., Parihar, Pankaj S., Konovolov, Kirill, Chen, Yu-Chia, Merrill, Ronald A, Wei, Hui, Carragher, Bridget, Sundaresan, Ramya, Cui, Qiang, Wadzinski, Brian E., Swingle, Mark R., Musiyenko, Alla, Honkanen, Richard, Chung, Wendy K., Suzuki, Aussie, Strack, Stefan, Huang, Xuhui, Xing, Yongna
Publicado 2023